|
HS Code |
138878 |
| Compound Name | 3-Bromo-4-methoxypyridine |
| Molecular Formula | C6H6BrNO |
| Molecular Weight | 188.02 g/mol |
| Cas Number | 39856-59-4 |
| Appearance | Light yellow to brown solid |
| Boiling Point | 121-123 °C at 14 mmHg |
| Melting Point | 41-43 °C |
| Density | 1.62 g/cm3 (predicted) |
| Solubility | Soluble in organic solvents (e.g., DMSO, methanol) |
| Smiles | COc1cc(ncc1)Br |
| Inchi | InChI=1S/C6H6BrNO/c1-9-6-3-5(7)4-8-2-6/h2-4H,1H3 |
| Refractive Index | 1.566 (predicted) |
As an accredited pyridine, 3-bromo-4-methoxy- factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | The chemical is supplied in a 25g amber glass bottle with a secure screw cap, labeled with hazard, chemical name, and safety information. |
| Container Loading (20′ FCL) | 20′ FCL: Packed in 200kg UN-approved drums, totaling 80 drums per container, safely secured for international sea transport. |
| Shipping | **Shipping Description:** Pyridine, 3-bromo-4-methoxy-, is shipped in tightly sealed containers, protected from light and moisture. Classified as a hazardous material, it requires labeling according to regulations for toxic and flammable liquids. Transportation must comply with DOT, IATA, and IMDG standards, ensuring secure handling to prevent leaks or exposure during transit. |
| Storage | 3-Bromo-4-methoxypyridine should be stored in a tightly sealed container, away from light, heat, and moisture. Keep it in a cool, dry, and well-ventilated area, separated from incompatibles such as strong oxidizers. Ensure containers are clearly labeled and handle under a fume hood if possible to avoid inhalation exposure. Always follow institutional safety protocols for chemical storage. |
| Shelf Life | Shelf life of 3-bromo-4-methoxypyridine is typically 2–3 years if stored tightly sealed in a cool, dry, and dark place. |
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Purity 98%: pyridine, 3-bromo-4-methoxy- with a purity of 98% is used in pharmaceutical intermediate synthesis, where it ensures high yield and product consistency. Melting Point 72°C: pyridine, 3-bromo-4-methoxy- with a melting point of 72°C is used in custom chemical manufacturing, where it provides process reliability and predictable crystallization. Molecular Weight 202.02 g/mol: pyridine, 3-bromo-4-methoxy- at a molecular weight of 202.02 g/mol is utilized in heterocyclic compound development, where it allows precise stoichiometric calculations. Stability Temperature up to 120°C: pyridine, 3-bromo-4-methoxy- with stability up to 120°C is employed in heated reaction processes, where it maintains structural integrity during synthesis. Residual Solvent <0.5%: pyridine, 3-bromo-4-methoxy- with residual solvents less than 0.5% is used in medicinal chemistry research, where it minimizes unwanted side reactions. Particle Size <100 µm: pyridine, 3-bromo-4-methoxy- with a particle size less than 100 µm is applied in solid-phase synthesis, where it enables efficient mixing and reaction kinetics. Water Content <0.2%: pyridine, 3-bromo-4-methoxy- with a water content below 0.2% is used in moisture-sensitive organic reactions, where it prevents hydrolysis and decomposition. Assay ≥99%: pyridine, 3-bromo-4-methoxy- with an assay of at least 99% is employed in analytical method development, where it guarantees reproducible quantification and analysis. Purity by HPLC 99.5%: pyridine, 3-bromo-4-methoxy- with a purity by HPLC of 99.5% is used in reference standard preparation, where it provides accuracy in calibration and quality control. Flash Point 96°C: pyridine, 3-bromo-4-methoxy- with a flash point of 96°C is used in controlled-temperature laboratory experiments, where it enhances operational safety. |
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Pyridine derivatives have shaped modern chemistry in ways that sneak into everything from the design of new medicines to the tech behind agricultural advances. Among these compounds, 3-bromo-4-methoxy-pyridine stands out for anyone wanting to push organic synthesis a little further. As someone who spent long hours at a bench wrestling with unpredictable reagents, I’ve learned how the difference between mediocre and high-purity chemicals shows up in the final yield every time. This particular compound resonates with researchers and developers chasing specific outcomes.
At its core, 3-bromo-4-methoxy-pyridine offers a subtle but crucial twist on the pyridine ring. With a bromo group at the third position and a methoxy group at the fourth, the molecule leans into both electron-donating and electron-withdrawing powers. Think of this arrangement like tweaking a stubborn recipe to hit just the right balance – a touch of sweetness, a whiff of bitterness, all built on a familiar backbone. Traditional pyridine brings its unique nitrogen atom to the table, but the extra groups here nudge reactivity into new territory.
In the real world of synthetic chemistry, the practical meaning comes down to versatility and reactivity. The methoxy moiety can help drive selectivity in further reactions, especially as a partner for cross-coupling. That extra methoxy at the 4-position gives organic chemists control over substitution patterns that would otherwise take multiple steps. Add the bromo at the 3-position, and now there’s a perfect handle for Suzuki, Heck, or Sonogashira reactions, all without unwanted byproducts that cloud up your experiment.
A bottle of 3-bromo-4-methoxy-pyridine isn’t just another label on the shelf. Typical purity levels for this product reach 98% or higher, which might not sound dramatic unless you’ve tried to coax a reaction along with a contaminated sample. Even a little impurity can kick the process in the wrong direction. The most reputable batches dissolve cleanly in common organic solvents – think DCM, THF, or acetonitrile – and come with a consistent melting point from batch to batch. The pale yellow to colorless liquid also signals a lack of tars or oxidized byproducts, which lets chemists get straight to work without extra clean-up steps.
For those who keep a close eye on storage and handling, stability under refrigeration protects this compound from breaking down into something less useful. The steely, sharp smell reminds you why ventilation matters – a detail all too familiar if you’ve ever forgotten to cap a bottle. Most labs with a sustainable safety record keep this reagent in small, airtight containers, usually under argon or nitrogen for the long haul.
Plenty of pyridine derivatives crowd the catalog, but the 3-bromo-4-methoxy substitution brings a sweet spot between chemical stability and targeted reactivity. In my own time working with heterocyclic intermediates, I found that brominated pyridines often outperform their chlorinated or unsubstituted cousins in selectivity. Chlorine atoms bring their own quirks to reactions – sometimes sluggish, sometimes stubbornly resistant to further transformation. Bromine, on the other hand, tends to participate more willingly under palladium catalysis, which is where so much of today’s innovative drug chemistry starts.
Methoxy strategies also have their storytelling power. Methoxy groups help direct other substituents in electrophilic aromatic substitution, and they can shift electron density enough to stabilize reactive intermediates. This directly shapes how a research project unfolds, whether that means hitting a tough regioisomer or unlocking a late-stage functionalization.
There’s a temptation to see all bromo-pyridines as interchangeable, but a side-by-side comparison quickly reveals differences in physical and chemical behavior. For instance, 2-bromo-pyridines often show less stability in air and struggle with solubility, while 3-bromo-4-methoxy hits a practical sweet spot. The solubility wins matter in scale-up as well as in initial discovery. If you’ve worked through a multi-step synthesis, you know how much time a reliable intermediate can save.
Talking with colleagues across medicinal and agricultural chemistry, the appeal of 3-bromo-4-methoxy-pyridine keeps coming up as a shortcut to more complex structures. In pharmaceutical development, it often plays the starting point for exploring new kinase inhibitors. The availability of a reactive bromo position means that combinatorial libraries can be built without extensive precursor preparation. The push for more sustainable, step-economical processes pushes this compound further into the limelight.
In crop science, labs keep turning to this compound for its role in the synthesis of selective herbicides. The methoxy group fine-tunes how the final product interacts with plant enzymes, and the ring system as a whole offers a balance between stability and biological activity. The same halogen-methoxy interplay allows customization that can adapt to regional needs, whether in terms of weed resistance or environmental persistence.
Diagnostic chemistry rarely makes headlines, but all those imaging probes and radiolabeled compounds tracing pathways in living tissue owe something to heterocyclic building blocks. Chemists seeking to attach radioisotopes or fluorescent tags value the site-directed reactivity, making 3-bromo-4-methoxy-pyridine a regular on purchase lists.
Anyone buying specialty chemicals wants to know what’s inside the bottle. This sounds basic, but I’ve seen projects hit the skids because a reagent didn’t meet its stated specs. That’s why traceability, lot tracking, and open disclosure of quality control data resonate with buyers. A trustworthy supplier backs up purity claims with chromatograms and NMR spectra, rather than marketing copy. Most high-quality sources provide detailed certificates of analysis with each shipment, giving peace of mind to teams running million-dollar research pipelines.
Regulatory compliance shapes the conversation, especially with supply chains running across borders. REACH and similar frameworks drive manufacturers to guarantee that every step, from raw material sourcing to final packaging, aligns with ethical and environmental standards. Knowing the provenance of your 3-bromo-4-methoxy-pyridine helps project leads answer questions that go far beyond the chemistry.
Not every lab can count on perfect supply chains or an endless research budget. Lead times and unexpected stockouts disrupt progress and put critical experiments on hold. I've watched more than one research project lose momentum because a single intermediate went backordered. Diversifying suppliers and forming direct relationships with manufacturers helps blunt this risk. It usually pays dividends in technical support, too.
Price also enters the equation. Specialty chemicals rarely come cheap, so cost-effectiveness means minimizing both wasted product and avoidable purification steps down the line. Forming consortia between labs to pool orders isn’t a new idea, but it continues to save money and open up discounts, especially on custom lots with tight specifications. For long-term storage or large-scale use, I’ve found that aliquoting into smaller containers on arrival extends shelf life and minimizes risk of spoilage.
On the bench, mishandling brominated pyridines can lead to messes both in the fume hood and in the data. Protective gear and proper storage go a long way, but simple reminders and checklists cut down on accidents. Regularly reviewing protocols and waste-management routines builds habits that protect both people and projects.
Reliable access to advanced building blocks fuels the spread of open research. Many of today’s breakthroughs rely less on brand new molecules and more on iterative improvement, process optimization, and a steady flow of high-quality intermediates. My time at various academic and industrial labs taught me that nobody wants to reinvent the wheel every week. Consistency builds confidence, which in turn frees innovation from fear of setbacks caused by questionable reagents.
Open sharing of data accelerates collective progress. Whenever a batch of 3-bromo-4-methoxy-pyridine enables a new patent or a better synthesis route, publishing those findings supports regulatory approval and calls for reproducibility. Leading research groups now include supplementary details on reagents down to the lot number and supplier, which helps untangle any confusion and paves the way for faster troubleshooting.
Sourcing specialty chemicals has started to shift toward greener methods, particularly as the next wave of researchers demands accountability. I’ve seen more suppliers embrace solvent recycling, reduced packaging, and improved logistics planning in the last five years alone. For a compound like 3-bromo-4-methoxy-pyridine, greener synthetic pathways cut down on hazardous byproducts and make the product more appealing for environmentally-minded teams.
In the future, alternative brominating agents and catalysis techniques will likely shrink the environmental footprint of small-batch production. Transparent reporting of emissions and waste streams, alongside regular third-party audits, sets the bar higher for those selling to leading research institutions. No matter how exotic or advanced a molecule, sustainability questions will keep influencing buying choices.
Genuine expertise with specialty chemicals grows over time, supported by hands-on experience and knowledge sharing across generations of scientists. Workshops, refresher courses, and webinars hosted by ingredient suppliers or academic centers bridge the gap between theory and practice. I remember swapping tips about purification tricks for bromo-pyridines with both early-career and seasoned chemists; those kitchen-table lessons proved more valuable than anything found in supplier brochures.
Mentoring new researchers to handle reagents with respect and curiosity builds good habits. Proper weighing, thoughtful planning of reaction schemes, and documenting outcomes ensure that future work can build on past success rather than repeat the same setbacks. The push for digital tracking of inventories and protocols now goes hand-in-hand with quality management, making it easier to spot and solve problems before they escalate.
Every research breakthrough stands on the shoulders of dependable materials. While the headlines will always shine brighter on the end products, the scaffolding provided by advanced intermediates like 3-bromo-4-methoxy-pyridine cannot be ignored. By streamlining challenging synthetic routes, enabling late-stage diversification, and keeping the door open to greener approaches, this molecule earns its place in the toolkit of future-oriented laboratories.
A favorite memory from my own time in the lab involves watching a colleague navigate an ambitious synthesis with limited resources. Access to the right intermediate at a crucial point made all the difference – it meant the project finished on schedule, and the results spoke for themselves. The experience reinforced my respect for careful sourcing, rigorous in-lab training, and the kind of team spirit that keeps science moving forward, even when the path winds through uncharted territory.
The market for high-purity, functionally rich building blocks keeps expanding as researchers tackle tougher problems in therapeutics, materials science, and sustainable agriculture. Every time a new application emerges for a derivative like 3-bromo-4-methoxy-pyridine, the questions start: Can it be sourced reliably? Are supply chains ethical? Will it perform consistently in real reactions, not just on paper? These aren’t just technical checkboxes; they’re reflections of a changing scientific culture focused on responsibility and real-world impact.
Today’s researchers expect more than chemical formulas; they want transparency, ethical sourcing, and the confidence that what they order will deliver what’s promised. Experience on the lab floor makes it clear that trust, communication, and a willingness to adapt are as crucial as molecular structure. Whether in a buzzing biotech incubator or a university teaching lab, a solid supply of compounds like 3-bromo-4-methoxy-pyridine will always underpin the work that drives modern innovation forward.
