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HS Code |
175342 |
| Iupac Name | N-(3-cyano-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)pyridine-3-carboxamide |
| Molecular Formula | C16H15N3OS |
| Molecular Weight | 297.38 g/mol |
| Cas Number | 1807983-45-4 |
| Appearance | Solid |
| Pubchem Cid | 155741162 |
| Smiles | C1CCC2=C(CC1)C(=CS2)NC(=O)C3=CN=CC=C3C#N |
| Inchi | InChI=1S/C16H15N3OS/c17-10-12-7-6-8-14-13(12)3-1-2-4-15(14)19-16(20)11-5-9-18-14/h5,7,9,11H,1-4,6,8H2,(H,19,20) |
| Storage Conditions | Store at room temperature, keep container tightly closed |
| Synonyms | None widely available |
| Chemical Class | Heterocyclic compound |
As an accredited N-(3-cyano-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)pyridine-3-carboxamide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | A 1g amber glass vial with a screw cap, featuring a printed label detailing chemical name, formula, CAS, and safety information. |
| Container Loading (20′ FCL) | Loaded in 20’ FCL drums, securely packed for chemical transport; compliant with safety standards; net weight per container as specified. |
| Shipping | This chemical, N-(3-cyano-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)pyridine-3-carboxamide, should be shipped in a tightly sealed container, protected from light and moisture. Transport under ambient temperature unless specified, and follow all regulations for potentially hazardous organic compounds. Include safety data sheets and ensure clear, compliant labeling throughout shipment. |
| Storage | Store **N-(3-cyano-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)pyridine-3-carboxamide** in a tightly sealed container, protected from light and moisture. Keep at room temperature or as recommended by the manufacturer, in a cool, dry, well-ventilated area, away from incompatible substances such as strong oxidizers. Clearly label the container and ensure access is restricted to trained personnel. |
| Shelf Life | Shelf life: Stable for at least 2 years when stored in a cool, dry, and dark place, tightly sealed, and moisture-free. |
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Purity 98%: N-(3-cyano-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)pyridine-3-carboxamide with purity 98% is used in pharmaceutical intermediate synthesis, where it ensures high-yield and minimized impurities in the final drug product. Molecular weight 298.38 g/mol: N-(3-cyano-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)pyridine-3-carboxamide with molecular weight 298.38 g/mol is used in medicinal chemistry screening campaigns, where standardized molecular mass enables accurate dose calculations and structure-activity relationship investigations. Melting point 205°C: N-(3-cyano-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)pyridine-3-carboxamide with a melting point of 205°C is used in solid-formulation research, where high thermal stability supports robust formulation under various processing temperatures. Particle size <20 μm: N-(3-cyano-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)pyridine-3-carboxamide with particle size below 20 μm is used in advanced drug delivery systems, where fine particle dispersion improves bioavailability and dissolution rates. Stability temperature up to 90°C: N-(3-cyano-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)pyridine-3-carboxamide with stability temperature up to 90°C is used in industrial chemical processes, where sustained efficacy is maintained during elevated reaction conditions. Solubility in DMSO >10 mg/mL: N-(3-cyano-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)pyridine-3-carboxamide with solubility in DMSO greater than 10 mg/mL is used in preclinical pharmacological studies, where enhanced solubility facilitates precise compound dosing and homogenous solution preparation. HPLC assay ≥99%: N-(3-cyano-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)pyridine-3-carboxamide with HPLC assay ≥99% is used in analytical quality control, where exceptional chemical purity ensures reliable and reproducible analytical results. LogP 2.8: N-(3-cyano-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)pyridine-3-carboxamide with LogP value of 2.8 is used in lead optimization programs, where balanced lipophilicity supports membrane permeability and favorable pharmacokinetic profiles. |
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Many years working on heterocyclic synthesis and scale-up taught me that complexity in structure often translates into new capability on the bench and in the plant. N-(3-cyano-5,6,7,8-tetrahydro-4H-cycloheptathiophen-2-yl)pyridine-3-carboxamide does more than tick a box on a catalog. Its fused bicyclic scaffold, featuring a functionalized pyridine ring and the distinctive cyclohepta[b]thiophene core, opens doors across the pharmaceutical and advanced materials markets. In our facilities, refined procedures ensure a reliable route to a product that offers both purity and scalability, so formulators and chemists downstream know what they’re getting, every batch, every time.
Our journey with this molecule started from the demands of medicinal chemistry teams who saw the potential in unique, partially saturated thiophene rings. To support them, we had to adjust reaction parameters, selecting solvents and conditions that favored high selectivity and minimized by-products associated with over-oxidation or side-chain scrambling. Batch reproducibility eventually exceeded tight margin targets, with typical material reaching at least 98 percent HPLC purity, usually higher, depending on filtration techniques and end user requirements.
Our synthetic route leverages sequential cyclization and functionalization steps. By closely controlling temperature ramps and workup timelines, we avoid common degradation pitfalls, especially around the sensitive cyano and carboxamide groups. Within the plant, operators favor inline NMR and LC-MS for stage monitoring, not just endpoint checks. Over time, our processes reduced the annual rate of out-of-spec batches to a low, manageable figure, reflected in both laboratory transparency and material reliability.
You see broad claims in chemical marketing, but the reality is that a molecular architecture like this, combining a rigidified bicyclic scaffold and two potent handle groups, rarely stays on the shelf for long. We supply early-stage chemical companies, academic research teams, and production chemists, most often within the pharmaceutical, agrochemical, and specialty materials sectors. Its cyclic structure with a readily activatable cyano group makes it valuable for late-stage functionalizations and structure-activity investigations.
The carboxamide group, chosen for hydrogen bonding potential and metabolic stability, often supports efforts to design kinase inhibitors or as an intermediate in morpholine-fused analog synthesis. Several development chemists have succeeded in using this compound in parallel synthesis campaigns, especially where aromatic substitutions or delicate electron-donating/withdrawing patterns are required. Product versatility isn’t just theoretical—it appears in downstream pipeline activity, where analogues holding this core chemistry have reached preclinical evaluation for inflammation and CNS disorders.
We maintain flexibility with order quantities. Whether it’s a handful of grams for medicinal chemistry or material for multiple kilo-scale campaigns, real-world efficiency depends on reliable conversion rates, not hopeful scale-up projections. Over the years, process adjustments—switching to more robust phase-transfer catalysts and implementing better in-process control—have shaved cycle times and improved yields by over 20 percent compared to early lab-scale runs.
For end users concerned about residual solvents and heavy metal contaminants, we share batch-specific impurity profiles. These profiles are tightly monitored, often falling well below internationally accepted thresholds for active pharmaceutical ingredient intermediates. This real data backs up our belief that trust in intermediates doesn’t come from claims—trust is earned in repeat lab results and fewer surprises during tech transfer and pilot batch campaigns.
Many thienopyridine and cycloheptathiophene analogs exist on the market, but most either lack a cyano handle or present purity challenges during critical coupling stages. Our N-(3-cyano-5,6,7,8-tetrahydro-4H-cycloheptathiophen-2-yl)pyridine-3-carboxamide’s defining differences lie not just in starting material selection, but our refusal to cut corners in the final purification sweep. Two-stage crystallization follows a short-path vacuum distillation, yielding product with defined polymorph profiles, proven by X-ray powder diffraction where client programs demand it.
On the technical front, the product’s moderate lipophilicity, enhanced by the partially saturated core, allows for more predictable ADME behavior in lead optimization than most fully aromatic analogs. Clients report that our material reduces false negatives in binding assays that otherwise stem from oxidative instability present in similar, less robust chemotypes. We often assist during formulation, and our technical support team helps design salt forms or co-crystals tailored to the nuances of each pipeline.
Through cycles of pilot and full-scale production, feedback arrived from discovery labs, kilo-labs, and custom manufacturing partners. We learned the subtle pain points first hand: slow dissolution in some solvents at colder temperatures, and batch-to-batch melting point drift reported by teams using different analytical protocols. To address this, we re-examined each purification and drying stage, resulting in both tighter lot verification and better particle morphology for end users in both solid and solution-phase chemistry.
Handling characteristics have also improved since the first pilot runs. New milling techniques limit static clustering and caking, making dispensing more straightforward from the bottle or drum—even in the controlled environments that require precise weighing for formulation batch records. Our internal labs have devised custom packaging for moisture-sensitive shipments, including single-use vials for pre-weighed aliquots, which saves valuable chemist and analyst time for those running series parallel projects.
Beyond composition and performance, customers have pushed for enhanced transparency in documentation. With each consignment, a thorough certificate of analysis provides not only key assay and impurity data, but evidence of batch traceability, IR, and mass spec confirmation. In the rare instance where a new impurity has appeared, our R&D team investigates root cause and corrective action, updating clients so that supply chain decisions don’t hang in doubt.
As a chemical manufacturer, waste minimization, solvent recovery, and energy reduction sit squarely in our operation’s targets. Our teams use closed-transfer systems to minimize airborne emissions during both synthesis and packaging. We began life-cycle analysis accounting for every input and ancillary material across all stages, feeding this data directly back to both process development chemistry and site management.
N-(3-cyano-5,6,7,8-tetrahydro-4H-cycloheptathiophen-2-yl)pyridine-3-carboxamide shows up in specialty polymer and pigment research. The conjugated bicyclic scaffold brings both electron richness and stability to materials that demand longer service lives under UV exposure. Polytechnic labs cite the utility of the compound in forming new donor-acceptor motifs, examining optical and semiconducting properties for applications in organic electronics.
Custom manufacturing projects in the agrochemical arena have tapped into the compound’s ability to act as a growth regulator intermediate, due to the robust nature of the fused-ring structure and chemical handles enabling downstream diversification. These uses require variations in particle size and solubility, which we meet by tailoring micronization and wet-milling methods, all supported by an in-house analytical team equipped with particle size analyzers and advanced imaging.
Our role as manufacturer, not distributor or labeler, means we respond directly to feedback from synthetic chemists, not through third parties. We’ve documented recurring issues such as sensitivity to acidic conditions during late-stage processing, and per customer’s request, have adjusted protocols to offer buffered sample solutions and packaged desiccant controls. For teams requiring scale-up batches for preclinical or field work, our track record shows routine ability to deliver 10–20 kilogram lots with the same attention to detail seen in early-stage material.
Our R&D partners have integrated customer feedback into each process revamp. For instance, concerns about the breakdown of the cyano group during energetic coupling reactions led us to re-examine both our core synthetic sequence and shipping temperature recommendations. Each improvement, documented and validated, comes out of a real working relationship with the chemists and project managers at the heart of each innovation.
Since we established our in-house research program, teams have pushed boundaries testing the compatibility of the product with new synthetic coupling agents and greener solvents. Our process control scientists keep a close watch on side-product formation, especially under the more difficult conditions required for larger scale manufacturing. This enables us to provide robust scientific data around potential degradation pathways, so that process teams have predictable results without the guesswork or downstream reprocessing.
Efforts track toward more sustainable sourcing for base chemicals, as part of a response to market and regulatory interest in green chemistry initiatives. Having invested in continuous flow chemistry equipment, we now produce trial batches minimizing solvent use and energy expenses, all while keeping the same high specifications customers count on. Routine process reviews paired with targeted feedback sessions ensure our approach never goes stale, and we can adjust in real time as application-specific needs emerge from discovery labs to pilot plants.
Comparing this compound to similar bicyclic thiophene and pyridine derivatives, differences appear in both its handling and adaptability. Straightforward, controlled reactivity—especially in the presence of nucleophiles or coupling partners—is a strong point. Users who struggled with other thiophene analogues noted major improvements in both overall yields and workup simplicity. Analysis teams no longer worry about the drifting impurity peaks and sudden color changes that plagued previous attempts with less stable scaffolds. Process transfer documentation has improved not only within our sites but in customer pilot plants worldwide.
Production methods continually evolve, shaped by years of hands-on experience with scale, impurity drift, and real-world feedback from partners ranging from small research startups to major life sciences players. Every batch tells a story about the care and control invested upstream—and that reliability becomes part of your project’s workflow.
In a sector saturated with overstatements and vague assurances, proof always wins out. We maintain open documentation on process validation steps, impurity qualification, and major deviations tracked directly to root cause. Technical data packages are tailored jointly with clients to meet the stringency of major regulatory and R&D milestones—real transparency that supports project continuity and risk management.
As global customers press for higher standards, our response is to prove, document, and update—not merely promise and promote. Fulfilling customer needs for clear, complete, and honest reporting forms the core of our expertise as a chemical manufacturer, and it shapes the way our teams work from first molecule to kilolab.
Our facility has invested in continual training and process development. The knowledge earned through continuous manufacture, feedback, and analytical review is what enables us to offer a product like N-(3-cyano-5,6,7,8-tetrahydro-4H-cycloheptathiophen-2-yl)pyridine-3-carboxamide, not simply as inventory but as a foundation for new discovery.
Over years of production and troubleshooting, our perspective focuses on real-world success: customers returning because their next step succeeded, impurities never jeopardized a key milestone, and regulatory clearances passed with clear documented checkpoints. In making and supplying complex intermediates, practical know-how and technical capability always take center stage, not marketing spin.
As application areas expand, our teams stand ready to address new technical queries about this molecule, from crystallography to formulation and beyond. Collaboration with customer research groups fosters improvements—an iterative process yielding benefits neither side can achieve alone. New market pressures, be they environmental, regulatory, or technical, serve as motivation to sustain a constant improvement mindset.
By rooting strategy in transparency, practical expertise, and technical rigor, we view each batch not just as another product, but a deliverable born out of experience, skill, and partnership. Whether supporting early research or full-scale commercial applications, we remain dedicated to meeting the scientific and operational demands associated with complex heterocyclic chemistries.
