|
HS Code |
319972 |
| Chemical Name | 5-Fluoro-4-formyl-2-methoxypyridine |
| Molecular Formula | C7H6FNO2 |
| Molecular Weight | 155.13 g/mol |
| Cas Number | 103877-27-2 |
| Appearance | Pale yellow to yellow solid |
| Melting Point | 42-46°C |
| Purity | Typically ≥98% |
| Solubility | Soluble in DMSO, slightly soluble in water |
| Storage Conditions | Store at room temperature, keep container tightly closed |
| Smiles | COC1=NC=C(C=O)C(F)=C1 |
| Inchi | InChI=1S/C7H6FNO2/c1-11-7-3-5(4-10)6(8)2-9-7/h2-4H,1H3 |
| Synonyms | 5-Fluoro-2-methoxy-4-pyridinecarboxaldehyde |
As an accredited 5-Fluoro-4-formyl-2-methoxypyridine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 5-Fluoro-4-formyl-2-methoxypyridine, 1g, supplied in an amber glass vial with tamper-evident seal and detailed labeling. |
| Container Loading (20′ FCL) | Container Loading (20′ FCL) for 5-Fluoro-4-formyl-2-methoxypyridine: Safely packed in sealed drums, total capacity ~14–16 metric tons. |
| Shipping | **Shipping Description for 5-Fluoro-4-formyl-2-methoxypyridine:** This chemical is shipped in a secure, airtight container to prevent contamination and degradation. The package is clearly labeled with hazard information and complies with regulatory guidelines for chemical transport. It is shipped at ambient temperature, with documentation including safety data sheets and handling instructions. |
| Storage | 5-Fluoro-4-formyl-2-methoxypyridine should be stored in a tightly closed container in a cool, dry, and well-ventilated area, away from sources of ignition and incompatible substances such as strong oxidizers. Protect from light and moisture. Ensure proper labeling and use secondary containment if necessary to prevent spills. Store at recommended temperatures, typically room temperature unless otherwise specified by the manufacturer. |
| Shelf Life | Shelf life of 5-Fluoro-4-formyl-2-methoxypyridine: Stable for at least 2 years when stored cool, dry, protected from light. |
|
Purity 98%: 5-Fluoro-4-formyl-2-methoxypyridine with purity 98% is used in pharmaceutical intermediate synthesis, where it ensures high product yield and chemical consistency. Melting point 65-68°C: 5-Fluoro-4-formyl-2-methoxypyridine with melting point 65-68°C is used in organic synthesis workflows, where stable handling and reproducible crystallization are critical. Molecular weight 157.12 g/mol: 5-Fluoro-4-formyl-2-methoxypyridine at 157.12 g/mol is used in medicinal chemistry projects, where accurate dosing and formulation are essential for bioactivity studies. Stability temperature up to 120°C: 5-Fluoro-4-formyl-2-methoxypyridine stable up to 120°C is used during reaction scale-up, where thermal stability prevents decomposition and side reactions. Particle size <25 μm: 5-Fluoro-4-formyl-2-methoxypyridine with particle size below 25 μm is used in fine chemical processes, where improved solubility and reaction kinetics are achieved. Water content <0.5%: 5-Fluoro-4-formyl-2-methoxypyridine with water content less than 0.5% is used in moisture-sensitive syntheses, where it prevents hydrolysis and maintains reaction integrity. Optical purity >99%: 5-Fluoro-4-formyl-2-methoxypyridine with optical purity over 99% is used in chiral drug development, where enantiomeric excess enhances pharmacological properties. Assay by HPLC ≥98%: 5-Fluoro-4-formyl-2-methoxypyridine assayed by HPLC at ≥98% is used in laboratory research, where analytical traceability supports quality assurance. Residual solvent <500 ppm: 5-Fluoro-4-formyl-2-methoxypyridine with residual solvent below 500 ppm is used in regulated manufacturing, where compliance with regulatory standards is mandatory. Synthetic grade: 5-Fluoro-4-formyl-2-methoxypyridine in synthetic grade is used in agrochemical discovery, where consistent quality accelerates lead compound identification. |
Competitive 5-Fluoro-4-formyl-2-methoxypyridine prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please contact us at +8615371019725 or mail to sales7@boxa-chem.com.
We will respond to you as soon as possible.
Tel: +8615371019725
Email: sales7@boxa-chem.com
Flexible payment, competitive price, premium service - Inquire now!
At first glance, 5-Fluoro-4-formyl-2-methoxypyridine sounds like one of those compounds that only matters to the niche few with a deep pocket protector and an even deeper knowledge of organic transformations. Still, anyone who has worked in pharmaceutical research or fine chemical development stumbles across molecules like this one: tightly specialized, precision tools that underpin larger and more meaningful innovations. I’ve watched projects rise or fall on the consistency and performance of such building blocks, often finding that the difference between a breakthrough and a setback comes down to the availability and quality of materials like these.
What stands out about 5-Fluoro-4-formyl-2-methoxypyridine is its three-pronged functionality: a fluorine atom, a reactive formyl group, and a methoxy group all attached to a six-membered pyridine ring. Each one of those handles offers chemists a chance to tune reactivity, make precise substitutions, or direct downstream reactions. The fluorine atom isn’t just for show; it provides metabolic stability, a trait especially valued in the development of drug candidates. The formyl group often acts as an invitation for more complex reactions, opening doors for elaboration or direct coupling. That methoxy group can shift electron density, helping dial in selectivity or reactivity in unexpected ways.
Anyone who has done hands-on organic synthesis quickly learns that the right starting materials can shave weeks off a project—or add months of troubleshooting. 5-Fluoro-4-formyl-2-methoxypyridine isn’t a commodity, and the market doesn’t flood with knock-offs. Behind every gram, there’s a history of reliable sourcing, batch traceability, and assurance about things like water content or residual solvents. Skipping quality can derail an entire synthetic campaign, especially when moving toward scale-up. This experience comes not just from textbooks, but from sifting through endless TLC plates or columns late at night, hoping that a byproduct didn’t sneak in from a sloppy reagent.
In a landscape crowded with hundreds of pyridine derivatives, there’s a reason this molecule grabs attention. It occupies a sweet spot for medicinal chemists and process developers who look for compounds that allow modifications at several sites without the risk of random side reactions. The balance comes partly from the spatial relationship between the fluorine and formyl groups. Too close, and unwanted cross-reactivity emerges. Too far, and the electron withdrawing effects get lost, making certain reactions sluggish or impossible.
Compared to plain 4-formylpyridine or its non-fluorinated cousin, adding fluorine at the 5-position often shifts metabolic profiles for the better. This single atom can reduce oxidative degradation, lengthen compound lifetime in biological systems, and increase lipophilicity just enough to tweak absorption rates. These characteristics explain why, as a chemist, I seek out materials prepared to defined specifications—not only for purity, but for consistent crystal form, particle size, and accurate labeling. Missteps cost time and trust, two things nobody can spare, especially in pharmaceutical development.
Other pyridine-based aldehydes or fluorinated variants lack the combination showcased here. Some offer a slightly more reactive aldehyde but lack the balance introduced by the methoxy. Others feature multiple fluorines, which dramatically skews reactivity or makes downstream transformations a headache. The triangle of groups present in 5-Fluoro-4-formyl-2-methoxypyridine serves multiple applications, acting as a reliable intermediate for complex molecule construction and library expansion—foundational aspects of drug discovery and advanced materials work.
People often see scientific progress as the product of headline-grabbing innovation, but real advancement comes from unheralded supporting actors like this molecule. Over the years, I have seen first-hand how a single reliable intermediate can unlock an entire pipeline of analogs or enable late-stage diversification. Medicinal chemists frequently explore variations of active compounds, searching for a balance of biological activity and drug-like properties. The unique blend of groups in 5-Fluoro-4-formyl-2-methoxypyridine hits a sweet spot, lending itself to Suzuki or Heck couplings, nucleophilic additions, or even more exotic cross-couplings with technologies like photoredox catalysis.
Beyond the bench, this compound finds its way into pilot plants or kilo labs that supply material for preclinical or clinical testing. At this scale, specifications become even tighter. Consistent melting point, absence of colored impurities, and batch reproducibility all move from “nice to have” to essential. I’ve seen plenty of promising leads scuttled because inconsistencies at this level force researchers to retest or revalidate steps. Working chemists don’t just want a molecule—they want it delivered with the same profile every time. That’s an expectation only met by deep expertise and robust quality assurance.
Exploring the fine print of modern patents and scientific literature, this compound quietly powers advances that ripple through the industry. Fluorinated pyridines remain lynchpins in antiviral, oncology, and neurological therapeutic areas. Academic groups use similar compounds to probe reaction mechanisms, creating new methods that feed back into industry. The formyl group, an often underappreciated functional handle, supports construction of heterocycles, imines, or advanced cross-couplings. As someone invested in both hands-on synthesis and the translation from bench to application, I have found that progress speeds up significantly with intermediates that offer modularity and reactivity in equal measure.
One underrated aspect involves regulatory documentation. Teams require certificates of analysis and batch histories that trace back every lot of starting materials. I have handled regulatory submissions where ambiguity or errors in precursor documentation led to week-long standstills. Only suppliers committed to transparency and data integrity can consistently support the painstaking standards required in both research and industry settings. This transparency extends beyond technical data—it encompasses shipment histories, real-time stock updates, and an understanding of both local and international shipping challenges, especially for temperature- or moisture-sensitive materials.
People sometimes ask if it’s worth sourcing a molecule with what seems like an arbitrary substitution pattern, especially when generic alternatives sit in catalogs. Experience proves that subtle structural changes mean everything. Take the fluorine atom. Drop it, and activity can fade or toxicity can spike in downstream compounds. Replace the methoxy with a methyl or ethyl group, and essential reactivity shifts away. These seemingly small changes send ripple effects through every subsequent step, from reactivity in the flask to metabolism in the human body.
While cost drives many procurement decisions, smart teams learn to weigh up-front savings against risk. Cheaper analogs bring unknown impurity profiles, unpredictable melting points, and headaches in analytical verification. Quality matters, especially when three months into a project, having to backtrack means burning through not just the budget, but the team’s morale. In my lab days, I learned to spot issues early: unexpected TLC spots, inconsistent yields or persistent off-colors meant impurity-laden starting materials. Reliable, specification-driven sourcing for compounds like 5-Fluoro-4-formyl-2-methoxypyridine shields a project from these setbacks, building confidence at every stage.
Research isn’t all theory; dirty flasks and missed conversions tell more stories than PowerPoint slides ever could. Reliable intermediates separate productive teams from those churning through troubleshooting meetings. Having access to 5-Fluoro-4-formyl-2-methoxypyridine on demand and at spec clears away many hidden obstacles. A smooth supply chain, supported by accurate documentation and expert advice, lets innovation flourish without constant fire-fighting.
Drawn from years spent mediating between procurement, chemistry teams, and regulatory experts, I see the broader lesson: knowledge and trust flow through every supply decision. Relying on this compound means staking project timelines, regulatory submissions, and personal reputations on the accuracy and care put in at every production step. The scientific world rewards institutions and individuals who consistently deliver quality, time after time. The stakes grow even higher in fields like oncology or infectious disease, where delays can mean missed opportunities to meet real patient needs.
In the push to develop safer, more selective medicines, the small building blocks receive little recognition compared to finished drugs on pharmacy shelves, but the path to approval runs through compounds like 5-Fluoro-4-formyl-2-methoxypyridine. Fine control over both purity and reactivity lets project teams design smarter, safer molecules at every step. Drawing on public health history, countless treatments started their journey thanks to reliable access to these intermediates, backing up efficacy and safety claims with real-world evidence and repeatable study results.
Supply reliability matters just as much as chemical identity. Resilient supply chains, clarity in documentation, and the expertise to solve problems on the fly block the spread of counterfeit or substandard reagents that have, in the past, caused recalls and crises. The industry’s sharpest minds only reach their potential with materials they can trust. Investment in these fine chemicals means investment in better health outcomes across the board.
For scientists building molecule libraries or scaling up production, I recommend keeping criteria tight: demand detailed specifications, analytical data, and a transparent chain of custody. Fast delivery and cost savings tempt, but those benefits vanish quickly when the first batch of final product doesn’t match expectations. Seasoned procurement teams look for more than a price tag; they ask about synthetic methods, analytical support, and the expertise behind the product.
In my experience, investing in trusted suppliers for molecules like 5-Fluoro-4-formyl-2-methoxypyridine builds institutional reliability. Teams freed from fire-drills and repeat analysis can devote resources to real innovation: optimizing reactions, inventing new bioactive structures, and answering questions that move science forward. Those working in start-ups or academic labs learn quickly how fragile progress can be—one missed shipment or impurity-laden batch, and timelines stretch, budgets balloon, or crucial funding vanishes.
Innovation doesn’t only happen in molecule design. The logistics of shipping, storage, and accountability improve every year. Vendors focused on environmental responsibility—offering recycled packaging, green manufacturing processes, or partnerships with logistics firms cutting emissions—begin to tilt the field. Forward-thinking teams treat technical excellence and environmental stewardship as partners, not trade-offs. Sourcing advanced intermediates like 5-Fluoro-4-formyl-2-methoxypyridine from suppliers with both cutting-edge production and sustainable practices meets the demands of both modern science and social responsibility.
I’ve seen collaboration improve outcomes more than fierce competition ever could. Academic labs reach milestones faster through partnerships with industry suppliers, sharing analytical data, best practices, and mutual respect. This feedback loop doesn’t just improve the product; it fosters trust across organizational walls, streamlining development and scaling work from milligrams to kilograms.
In the rush to discover and commercialize breakthrough medicines, battery technologies, or specialty materials, it’s easy to overlook foundational components like 5-Fluoro-4-formyl-2-methoxypyridine. From hands-on experience, I can say it’s smarter not to underestimate their power. The science behind a blockbuster drug or a next-gen device can stall without the right materials, sourced carefully and thoughtfully. Education, expert support, and a willingness to demand the best recipes and supply practices help defang many persistent problems plaguing labs and manufacturing floors alike.
Through years of troubleshooting reactions, guiding scale-ups, and collaborating across time zones and language barriers, I have noticed that partnerships built around expertise and transparency provide lasting advantages. Scientists and project managers not only deliver on immediate objectives but build reputations that beckon opportunity. At every stage, compounds like 5-Fluoro-4-formyl-2-methoxypyridine sharpen the edge of discovery, making ambitious goals just a bit more tangible—one carefully crafted molecule at a time.
