|
HS Code |
268720 |
| Cas Number | 3430-22-2 |
| Molecular Formula | C6H4ClNO |
| Molecular Weight | 141.56 g/mol |
| Iupac Name | 5-chloropyridine-2-carbaldehyde |
| Appearance | Light yellow to pale brown solid |
| Boiling Point | 271.1 °C (estimated) |
| Melting Point | 49-52 °C |
| Density | 1.32 g/cm³ (estimated) |
| Solubility | Soluble in organic solvents such as dichloromethane and ethanol |
| Smiles | C1=CC(=NC=C1Cl)C=O |
As an accredited 5-Chloro-2-formylpyridine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 5-Chloro-2-formylpyridine, 25g: Supplied in a sealed amber glass bottle with tamper-evident cap and chemical hazard labeling. |
| Container Loading (20′ FCL) | **Container Loading (20′ FCL):** Holds approximately 12–14 metric tons of 5-Chloro-2-formylpyridine, securely packed in sealed drums or barrels to prevent leakage. |
| Shipping | 5-Chloro-2-formylpyridine is shipped in tightly sealed containers under cool, dry conditions to prevent moisture and contamination. Packages are clearly labeled with hazard information, complying with local and international transport regulations. Handle with appropriate protective equipment, and ensure shipment follows guidelines for hazardous chemicals, including documentation and emergency procedures. |
| Storage | 5-Chloro-2-formylpyridine should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area, away from sources of ignition and incompatible substances such as strong oxidizing agents. Protect from moisture and direct sunlight. Properly label the container and keep it in a designated chemical storage cabinet, following local regulations and safety guidelines for hazardous organic compounds. |
| Shelf Life | 5-Chloro-2-formylpyridine should be stored cool and dry; shelf life is typically 2–3 years in unopened, airtight containers. |
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Purity 98%: 5-Chloro-2-formylpyridine with 98% purity is used in pharmaceutical intermediate synthesis, where it ensures high yield and minimal side-product formation. Melting point 61–63°C: 5-Chloro-2-formylpyridine with a melting point of 61–63°C is used in solid-phase organic reactions, where it promotes consistent processability and reproducible product recovery. Molecular weight 143.55 g/mol: 5-Chloro-2-formylpyridine at a molecular weight of 143.55 g/mol is utilized in heterocyclic compound development, where accurate stoichiometric calculations improve reaction efficiency. Stability temperature up to 120°C: 5-Chloro-2-formylpyridine stable up to 120°C is employed in high-temperature synthesis protocols, where it exhibits reliable chemical integrity and minimal degradation. Low water content ≤0.5%: 5-Chloro-2-formylpyridine with water content ≤0.5% is used in moisture-sensitive catalytic processes, where reactive purity leads to enhanced catalyst performance. |
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Curiosity always leads us to seek something better in the toolbox, especially in organic chemistry labs. Among the many pyridine derivatives I've worked with, 5-Chloro-2-formylpyridine stands out. Its chemical structure—where a chlorine atom takes the 5-position and a formyl group claims the 2-position—proves crucial. The combination of electron-withdrawing chlorine and electron-rich formyl creates an interesting platform for further modification. Many researchers trust this compound for its high purity and predictable behavior across diverse reaction conditions.
Purity makes all the difference, especially once you notice small impurities can throw off complex reactions. In most lab-grade versions, you get 5-Chloro-2-formylpyridine as a solid or crystalline powder. Its molecular formula is C6H4ClNO, with a molecular weight around 141.55 g/mol. Its melting point lies in a range that fits comfortably for standard handling, though ambient humidity can affect its form. Color typically leans toward pale yellow—a feature that helps distinguish it from other pyridine derivatives sitting side-by-side on crowded shelves.
Solubility also matters. 5-Chloro-2-formylpyridine dissolves well in most polar organic solvents. For example, I've never had issues when adding it to DMF, DMSO, or acetonitrile. This makes it easier to measure, mix, and monitor during multistep syntheses. Plus, it leaves fewer clumps, so even a quick glance at the solution tells you the compound has dispersed properly.
I’ve learned through many long afternoons in the lab that versatility keeps a chemical on the shopping list. 5-Chloro-2-formylpyridine checks this box for medicinal and organic chemists. Because it carries both a reactive aldehyde group and a halogen, it plays dual roles in both nucleophilic aromatic substitution and condensation reactions. You don’t have to look far—many students start using it during synthesis of pharmaceutical intermediates, agrochemical prototypes, and even ligands for metal coordination complexes.
Some of my colleagues use it to anchor functional groups onto the pyridine ring. The aldehyde is just begging for reagents like hydrazines or amines, leading to Schiff bases and hydrazones. These products feed into bigger, more complex molecules. Chlorine substitution lets you introduce new groups via cross-coupling, driving innovation in heterocyclic compound libraries. Strong demand in combinatorial chemistry and fragment-based drug design keeps 5-Chloro-2-formylpyridine in stock at many research facilities.
After comparing several options in the pyridine series, I’ve found 5-Chloro-2-formylpyridine stands out for a couple of reasons. Unlike 2-formylpyridine, the chlorine sitting in the 5-position unlocks unique electronic properties. These impact how the molecule behaves under both acidic and basic conditions. For example, reaction rates in alkylation or halogen exchange proceed differently compared to simple 2-formylpyridine.
The presence of a halogen isn’t just a detail. It changes the reactivity profile, allowing for selectivity in many transformations. In practice, this can mean fewer side products, easier isolations, and better final yields. In contrast, non-chlorinated analogues often require additional protection or deprotection steps, which can complicate your workflow and increase solvent consumption. Time is money, especially when you face grant deadlines. Reducing these unnecessary steps makes a real difference.
5-Chloro-2-formylpyridine also addresses stability concerns. Some aldehyde-containing pyridines oxidize or polymerize unexpectedly if stored improperly. This compound, on the other hand, resists air degradation better—thanks in part to the electronic pull of chlorine. It holds up under light and regular room temperature conditions better than others in its class. I’ve lost more than a few grams of 2-formylpyridine to off odors and discoloration, but the chloro-derived alternative measures up over time.
Nobody wants surprises when working with reactive chemicals. 5-Chloro-2-formylpyridine gives a slight almond scent—the aldehyde group at work—so proper fume hood usage improves the experience. Sensitization can occur if you allow skin or prolonged inhalation exposure, as with most aromatic aldehydes. I always recommend gloves and eye protection, and keeping an eye on local policies regarding storage of potentially hazardous chemicals.
From my own handling, spills clean up well with a small amount of ethanol and absorbent pads. Residues rinse away from glassware more easily than with other sticky pyridine analogues. Still, avoid excess heat or prolonged open-air storage. Its stability does not excuse lapses in basic lab hygiene—keep the lid tight and label fresh.
The literature backs up what daily lab use confirms. Over the past decade, reports in The Journal of Organic Chemistry and Synthesis illustrate broad adoption of this compound. Chemists use 5-Chloro-2-formylpyridine to create fused heterocycles, essential for both medicinal and materials chemistry. The dual functionality—halogen and formyl—enables shorter synthetic routes. For example, in studies on new antifungal agents, scientists substituted chlorine directly for fluorine or bromine to tweak activity. Formyl targeting provided useful intermediates en route to chiral building blocks.
Industrial scale-up benefits as well, since robust reactivity across solvent systems translates from small scale to larger batches. The formyl group’s ease of derivatization proves valuable for making specialized ligands and dyes. Electrochemistry teams often leverage the predictable electron distribution to develop new redox-active salts. Few alternatives offer this same mix of control and adaptability—a view shared by practitioners across several continents.
No chemical comes without its quirks. Supply chain interruptions sometimes limit availability of high-purity material. During pandemic slowdowns, researchers faced delays when sourcing specialty reagents, including this one. Plenty of users pivoted to local or regional suppliers, sometimes accepting slightly lower purity.
Some scaling challenges emerge when switching from bench to industry. Chlorinated pyridine derivatives demand careful effluent treatment, so waste management costs rise with frequent use. Laboratories must follow protocols to minimize environmental impact, given the persistence of chlorinated aromatics. Controlling emissions and practicing responsible disposal matter—not just for regulatory compliance but for the shared health of water and soil.
Price swings reflect demand and the cost of starting materials. In tight grant cycles, cost-conscious researchers sometimes replace it with less tailored pyridines. Results don’t always match up. The substitution flexibility and high conversion rates of 5-Chloro-2-formylpyridine justify the expense, especially for critical experimental runs.
Real progress comes by investing in greener synthesis routes. Some labs pursue in-house preparation methods using safer chlorinating agents and recyclable solvents. Streamlining purification steps saves both money and time. Encouragement of open-source protocols helps define best practices, reducing batch-to-batch variation and maximizing yield. In my view, fostering collaboration between academia and commercial suppliers can stabilize pricing, build supply resilience, and address purity concerns for sensitive applications.
Waste treatment technologies continue improving. On-site neutralization and effective filtration bring labs up to stricter environmental standards. Advanced oxidation processes degrade chlorinated byproducts before they leave the facility, helping close the loop. Responsible labs keep records and train personnel in updated waste handling, ensuring that benefits of the compound don’t add unnecessarily to environmental burdens.
Education matters as well. Trainees learn about selective chemistry with 5-Chloro-2-formylpyridine while absorbing lessons in risk management. Experience prepping stock solutions, handling residues, and troubleshooting reactions builds long-term capacity. Sharing troubleshooting tips—such as managing off odors or improving crystallization—through research forums strengthens the entire community relying on the compound.
I’ve seen genuine energy in research meetings when someone brings up a new result using 5-Chloro-2-formylpyridine. It unlocks new directions in fragment-based libraries, accelerates the search for drug candidates, and simplifies synthetic sequences in ways that save both reagents and patience. The versatility keeps it in regular rotation, even as other tools come and go.
Fresh directions include exploring its use in ligand frameworks for metal-organic frameworks and catalysis. Polymers and advanced materials researchers take advantage of the unique combination of reactivity and stability, designing stepwise functionalization schemes that open up new physical properties. Much like classic workhorses in synthetic chemistry, this compound carves a permanent spot thanks to its reliability and adaptability.
Emerging technologies benefit from its use, too. Automated synthesis platforms rely on reagents that deliver predictable results—there’s less appetite for variables that could ruin data integrity. Artificial intelligence platforms designing new molecules feed off robust and well-documented building blocks, and 5-Chloro-2-formylpyridine fits that mold. It’s no surprise to find it featured in machine-generated routes and automated screening libraries.
Many years spent working at the bench have taught me the importance of sticking with reliable building blocks. 5-Chloro-2-formylpyridine belongs in that trusted category. From the perspective of anyone who has mixed, reacted, or purified it, the advantages extend beyond what standard datasheets express. Its predictable chemistry, ease of integration, and resilience through supply hiccups give it staying power. Challenges remain—especially regarding waste management and sustainable sourcing—yet the community continues to address them with growing awareness.
Anyone stepping into the realm of modern organic synthesis should get familiar with this compound. Whether you’re building scaffolds for drug discovery, exploring new functional materials, or just solving day-to-day synthetic puzzles, you’ll find value in what it offers. The lessons learned while working with 5-Chloro-2-formylpyridine point toward an approach rooted in both respect for classic chemistry and the drive to innovate responsibly.
Looking back at the journey with this compound, I find that familiarity brings both insight and a healthy sense of caution. The molecule’s strengths shine brightest when you take the time to understand its unique blend of reactivity and stability. Careful planning, respect for safety, and diligent waste handling define best practices with aromatic aldehydes and halogenated derivatives alike. Every time I prepare a new batch, I recall both success and the occasional setback, learning to adjust, improve, and keep an eye on efficiency.
Peer-to-peer sharing of protocols and lessons advances everyone’s practice, improving outcomes and reducing troubleshooting headaches. Highlighting both what works and where the sticking points lie does more than pad the literature; it brings genuine progress. As chemical research links more tightly with environmental responsibility and real-world impact, 5-Chloro-2-formylpyridine shows how a legacy molecule still drives tomorrow’s discoveries. Not every compound can claim such steady demand or such a meaningful role in innovation, but this one earns its place every cycle, every publication, every experiment.
