|
HS Code |
430073 |
| Iupac Name | 4-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine |
| Molecular Formula | C8H8ClN |
| Molecular Weight | 153.61 g/mol |
| Cas Number | 104055-82-9 |
| Appearance | Colorless to pale yellow liquid |
| Boiling Point | Unknown |
| Melting Point | Unknown |
| Density | Unknown |
| Solubility In Water | Unknown |
| Smiles | Clc1ncccc2CCCC12 |
| Inchi | InChI=1S/C8H8ClN/c9-7-5-6-3-1-2-4-8(6)10-7/h5H,1-4H2 |
| Pubchem Cid | 11467078 |
| Flash Point | Unknown |
| Synonyms | 4-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine |
As an accredited 4-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | White plastic bottle containing 25 grams of 4-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine, labeled with safety, handling, and identification details. |
| Container Loading (20′ FCL) | 20′ FCL container loads approximately 12 MT of 4-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine, securely packed in drums or IBCs. |
| Shipping | 4-Chloro-6,7-dihydro-5H-cyclopenta[b]pyridine should be shipped in accordance with relevant chemical transportation regulations. Use tightly sealed, chemically compatible containers and appropriate hazard labeling. Protect from moisture and physical damage. Ship under ambient temperature unless otherwise specified in the safety data sheet (SDS). Ensure documentation accompanies the package for safe handling and emergency information. |
| Storage | Store **4-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine** in a tightly sealed container in a cool, dry, and well-ventilated area, away from direct sunlight and incompatible substances such as strong oxidizing agents. Avoid exposure to moisture and sources of ignition. Label the container clearly and follow all relevant safety protocols for handling and disposal of organic chemicals. |
| Shelf Life | Shelf life: 4-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine should remain stable for at least 2 years if stored properly. |
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Purity 98%: 4-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine with purity 98% is used in pharmaceutical intermediate synthesis, where high purity ensures minimal by-product formation. Melting point 81°C: 4-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine with a melting point of 81°C is used in solid-state organic reactions, where stable handling and controlled reactivity are required. Molecular weight 167.63 g/mol: 4-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine at 167.63 g/mol is used in medicinal chemistry research, where precise molecular mass supports accurate formulation and dosing studies. Stability temperature 120°C: 4-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine with a stability temperature of 120°C is used in high-temperature reaction processes, where thermal stability ensures consistent performance. Particle size <50 μm: 4-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine with particle size below 50 μm is used in suspension formulations, where fine dispersion improves homogeneity and bioavailability. Water solubility <0.1 mg/mL: 4-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine with water solubility less than 0.1 mg/mL is used in hydrophobic compound screening, where low aqueous solubility enhances selective extraction and separation processes. |
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Every year, the world of heterocyclic chemistry brings forward new possibilities for laboratories and industrial users. Our team spends much of its time at the intersection of process innovation and hands-on craftsmanship, and one compound regularly ordered by long-term partners is 4-chloro-6,7-dihydro-5H-cyclopentapyridine. This molecule, described by its core cyclopenta structure fused to a pyridine ring with a chlorine atom strategically placed at the fourth position, has proven valuable for a spectrum of chemical transformations. Our deeper experience comes not just from scale-up, but from running dozens of pilot and multi-ton batches where tight controls define outcome and repeatability.
From early in-house route scouting to consistent kilo runs, reliable access to high-purity 4-chloro-6,7-dihydro-5H-cyclopentapyridine makes a distinct difference for many users. Customers depend on our process controls to meet stringent quality standards. Walk into our production line and you’ll see the safeguarding measures that underpin every synthesis: gas flow monitoring, pressure controls, overhead nitrogen purges, and maintenance of glass-lined reactors free of any cross-contamination. Keeping trace impurities at a minimum, especially those known to impact downstream functionalization reactions, often requires process tweaks and constant batch verification. Our lab technicians run frequent HPLC and GC-MS checks to make sure we don’t just hit a spec sheet once, but sustain it across campaigns.
It takes more than just an efficient synthetic route to offer a solid product. For us, that means focusing on every parameter along the batch—solvent choice, base scavenging, control over temperature ramps, and quench handling post-reaction. Each time we make 4-chloro-6,7-dihydro-5H-cyclopentapyridine for a customer’s project, we apply preventive maintenance and double-check logbooks before charging the reactor. Long experience shows that even a small equipment oversight can create unplanned side products, as the cyclopenta framework shows a tendency for rearrangement under certain conditions. Consistent results rely as much on discipline and documentation as chemical ingenuity.
Our product commonly ships as an off-white crystalline solid, maintained in double bags under inert atmosphere. We’ve learned to avoid glass ampoules unless specifically requested—the crystalline nature enables easy handling in robust polyethylene containers, reducing the risk of shattering and unwanted contamination from ambient moisture. Standard lots vary from grams for early research, up to hundreds of kilos for established manufacturing campaigns. At elevated quantities, packing integrity becomes as crucial as purity itself, and we routinely check for clumping, swelling, or any evidence of caking in stored lots through routine shelf-life studies.
Preparation of this compound often incorporates approaches such as selective chlorination or cyclization from precursors like 4-chloropyridines or related carbocyclic intermediates. From a process chemistry standpoint, controlling the position and degree of chlorination plays a great role—overchlorination or migration events yield impurities that prove tough to remove cost-effectively after the fact. By maintaining optimized reaction conditions and post-synthesis purification, we’ve reached reproducible purity profiles, typically above 98% by HPLC. Solvent residues must fall well below 0.5%, and key inorganics—specifically chlorides—remain controlled and quantified via titration.
Our track record stems from ongoing method review and validation. Every campaign reveals something new, even after years of operation. We regularly adjust our crystallization method or filtration system based on subtle physical observations. For example, a slight turbidity in the wet cake can forewarn of incomplete washing or stagnant flow in the filter press—a lesson learned from one campaign that nearly delayed a multi-ton shipment. Detailing our interventions during processing, and ensuring lot-to-lot consistency, gives customers greater trust in each order received.
Customers approach us for this molecule mainly for its function as a versatile intermediate. The cyclopenta fused pyridine motif features in several pharmaceutical scaffolds and advanced agrochemical molecules. Owing to the electron-withdrawing effect of chlorine at position 4, further nucleophilic substitution comes with greater selectivity. As a direct result, chemists can introduce amine, alkoxide, or heteroaryl groups into the core with less risk of unplanned ring opening or reduction. The molecule’s performance in Suzuki or Buchwald-type coupling is well known across process groups that reach out to us regularly for larger quantities.
Our customer’s projects span medicinal chemistry campaigns aimed at kinase inhibitor leads, as well as industrial teams seeking to develop process routes for pyridine derivatives. Over time, feedback from these partners led us to refine the handling guidelines we provide, including solvent compatibility notes and optimum storage conditions. Complex reactions—especially those requiring organometallics—can trigger side reactions if trace acids or moisture accompany a shipment. In response, we added sealing with moisture scavengers for critical lots and trained our logistics team to pack and ship in compliance with those requirements, giving direct feedback to improve our own protocols.
Contrast with other pyridine derivatives offers insight into the choices chemists make every day. While typical chloro-pyridines show moderate reactivity, our 4-chloro-6,7-dihydro-5H-cyclopentapyridine offers an expanded reactivity window thanks to the expanded ring. By introducing rigidity and steric bulk through the fused cyclopenta structure, this substrate favors selectivity in both aromatic and aliphatic substitutions. Where simple pyridine chlorides may succumb to over-reduction or lead to regioisomeric impurities, the rigidity of this compound helps keep transformation predictable and controllable on scale.
Comparing with closely related intermediates, such as 4-chloro-2,3,6,7-tetrahydro-5H-cyclopentapyridine or 4-chloropyridine, the differences in outcome become clear after running bench tests and scaling up pilot campaigns. Availability of functional handles on the saturated carbocycle can direct reactivity, as well as affect physical handling properties—4-chloro-6,7-dihydro-5H-cyclopentapyridine maintains better processability at moderate temperatures and does not require excessive cooling or stabilization unlike more reactive dihydropyridines. Pursuing high purity at scale, with fewer byproducts in downstream coupling reactions, justifies its use even where slightly higher cost per kilogram arises.
Being a manufacturer at the core, we measure product value not only by how pure it is, but by how each lot delivers on real-world application. Chemists in our team routinely run control trials on finished batches, pushing the limits of shelf-life, heat stability, and solvent compatibility. One recurring topic in our process meetings involves learning from customer returns or inquiries—sometimes a tailored filtration step, or a tweak in drying parameters, keeps particle size distribution optimal for rapid charging and reproducible yields in custom reactors.
Our teams organize regular "round table" reviews, pulling operators, analytical chemists, and engineers together. This close feedback loop informs improvements across the plant floor. It’s not rare for a batch campaign to prompt a method modification; a past incident where crystal agglomeration led to a minor clog in a customer’s automated addition system prompted us to rework the drying step, install real-time temperature mapping, and adopt a secondary sieving operation for large campaigns. No product advances without incorporating these lessons directly from manufacturing trenches.
We remain mindful of regulatory landscape shifts, and our documentation protocols trace each lot of 4-chloro-6,7-dihydro-5H-cyclopentapyridine back to starting raw materials. Each batch passes full trace element identification and residual solvent analysis, with dedicated recordkeeping for at least five years after shipment. Our internal auditing protocols parallel many cGMP practices, even for non-pharmaceutical supply, and we monitor updates from regulatory bodies affecting allowable impurity profiles or shipping restrictions.
Inspecting global chemical market trends, we recognize fluctuations in precursor supply chains, and actively maintain alternate sourcing strategies for all key raw materials. In periods of volatility or constrained transport, these steps have given us the flexibility to continue on-time production when other sources run dry. Customers benefit by experiencing minimal disruption as demand cycles or unforeseen challenges hit the global logistics network. Respect for documentation and supply transparency forms a cornerstone of our approach—nothing erodes trust more than a missing CoA or inadequate lot traceability.
Each chemical manufacturer faces daily choices about cost optimization, risk control, and honest communication. From our plant’s perspective, success with 4-chloro-6,7-dihydro-5H-cyclopentapyridine arises from addressing challenges as they emerge. Whether it means iterative solvent recovery, rerunning analytical calibrations, or simply listening to a veteran operator spot-checking the process, every batch tells a story of discipline and direct engagement. We don’t approach production as a mechanical routine, but as a craft honed by years troubleshooting reactions, investing in robust infrastructure, and welcoming dialogue with partners who share the same focus on tangible results at scale.
We believe strong supplier-client relationships derive from candor and reliability. Whenever we receive feedback on solubility differences, unexpected behavior in a bench reaction, or changing project needs, our technical team works to understand the context and resolve the root cause. We retrace reaction logs, review in-process analytics, and sometimes reprocess material, knowing that maintaining strict standards pays long-term dividends both for our customers’ success and our own reputation in the industry. Our willingness to provide tailored support and deep-dive technical assistance sets us apart from intermediaries who lack direct process knowledge and hands-on operational insight.
Manufacturing 4-chloro-6,7-dihydro-5H-cyclopentapyridine isn’t just a matter of conversion efficiency in reactors; it brings a responsibility to environmental stewardship and safe operations. We invest in efficient solvent reclamation, responsible waste management, and careful handling of chlorinated intermediates to minimize our ecological footprint. Teams running the plant monitor air emissions, wastewater output, and energy load, and continually assess our operations for further improvement. We participate in industry collaborations to share lessons learned on safe handling of chlorinated heterocycles, and consistently update our protocols to meet or exceed the latest standards for worker protection and environmental compliance.
Reducing hazardous waste and improving our use of sustainable materials align directly with our commitment to help our customers meet their own sustainability goals. Over the past few years, process innovations have reduced our chemical solvent usage by nearly a quarter, and improved overall product yield. These improvements come both from technical optimization and suggestions from employees on the production floor. We don’t view green manufacturing as a business add-on, but as an integral part of a manufacturer’s responsibilities.
4-chloro-6,7-dihydro-5H-cyclopentapyridine isn’t a commodity on the shelf—it’s the result of thousands of hours refining both process and physical handling, batch after batch. Chemists, engineers, and technicians all contribute, sharing a sense of responsibility that stretches well beyond the production line. Supplying this intermediate to teams at the cutting edge of discovery gives us a front-row seat to how new compounds, drugs, and materials take shape. Feedback loops with our customers keep us agile and in tune with changes in research direction, providing new inspiration to refine and improve our methods further.
Whether supporting research as teams search for breakthrough pharmaceuticals or bolstering global supply chains for established products, 4-chloro-6,7-dihydro-5H-cyclopentapyridine demonstrates that real value in chemistry comes from a combination of technical know-how, direct manufacturing expertise, and honest partnership. By building our operations on a strong base of documentation, ongoing improvement, and close attention to every detail, we ensure this product remains a reliable choice for teams who share our passion for tangible, reproducible results at scale.
