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HS Code |
208175 |
| Chemical Name | 4-bromo-2,6-difluoropyridine |
| Molecular Formula | C5H2BrF2N |
| Molecular Weight | 194.98 |
| Cas Number | 452972-18-2 |
| Appearance | Colorless to pale yellow liquid |
| Boiling Point | 181-182°C |
| Density | 1.78 g/cm3 |
| Purity | Typically ≥98% |
| Refractive Index | 1.519 |
| Solubility | Soluble in organic solvents (e.g., DMSO, methanol) |
| Smiles | C1=CC(=NC(=C1F)Br)F |
| Inchi | InChI=1S/C5H2BrF2N/c6-3-1-2-4(7)9-5(3)8 |
| Storage Conditions | Store at room temperature, tightly closed |
As an accredited 4-bromo-2,6-difluoropyridine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Amber glass bottle containing 25 grams of 4-bromo-2,6-difluoropyridine, sealed with a PTFE-lined cap and labeled for laboratory use. |
| Container Loading (20′ FCL) | Container Loading (20′ FCL) for 4-bromo-2,6-difluoropyridine ensures secure, compliant drum or bag packaging to prevent leaks during transit. |
| Shipping | 4-Bromo-2,6-difluoropyridine is shipped in tightly sealed, chemical-resistant containers to prevent leaks or contamination. It is transported according to regulations for hazardous chemicals, typically under ambient conditions. Proper labeling, documentation, and handling procedures are followed to ensure safety and compliance with international and local shipping laws. |
| Storage | 4-Bromo-2,6-difluoropyridine should be stored in a cool, dry, and well-ventilated area, away from sources of ignition and incompatible substances such as strong oxidizing agents. Keep the container tightly closed and protected from moisture. Store at room temperature and avoid prolonged exposure to light. Follow standard laboratory chemical storage protocols and ensure proper labeling for safe identification. |
| Shelf Life | 4-bromo-2,6-difluoropyridine typically has a shelf life of at least 2 years when stored in a cool, dry, airtight container. |
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Purity 98%: 4-bromo-2,6-difluoropyridine of 98% purity is used in pharmaceutical intermediate synthesis, where high purity ensures minimal by-product formation. Melting Point 35-38°C: 4-bromo-2,6-difluoropyridine with a melting point of 35-38°C is applied in agrochemical research, where controlled melting ensures precise formulation blending. Stability Temperature up to 120°C: 4-bromo-2,6-difluoropyridine stable up to 120°C is used in high-temperature coupling reactions, where maintained integrity under thermal conditions enhances reaction yield. Molecular Weight 208.96 g/mol: 4-bromo-2,6-difluoropyridine with a molecular weight of 208.96 g/mol is utilized in medicinal chemistry, where specific mass aids in accurate stoichiometric calculations. Moisture Content <0.5%: 4-bromo-2,6-difluoropyridine with moisture content less than 0.5% is employed in fine chemical production, where low moisture prevents hydrolytic degradation of reactants. Particle Size <150 microns: 4-bromo-2,6-difluoropyridine with a particle size below 150 microns is used in solid-phase synthesis, where fine granularity ensures homogeneous mixing and reactivity. |
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4-Bromo-2,6-difluoropyridine stands out among pyridine derivatives due to its carefully chosen combination of halogen atoms, which makes it an attractive molecule for researchers and manufacturers who work at the frontiers of medicinal and materials chemistry. This compound, represented by the formula C5H2BrF2N, shows a tight, robust structure. Scientists often use it for the way the bromine at the 4-position opens opportunities for further manipulations and coupling reactions, while the fluorines at the 2 and 6 positions deliver unique electronic properties.
I remember sitting with a chemist friend who explained how swapping just one atom in a molecule can lead to a completely different set of reactivity and biological effects. In the case of this compound, the precise placement of the halogens impacts not only the molecule’s physical behavior, but also its effectiveness in the synthesis of complex chemical entities. For many, this precise control changes the game compared to more generic halopyridines on the market.
You don’t often see such respect for a relatively simple molecule in synthetic circles. Chemists have learned that adding fluorine to a pyridine ring doesn’t just tweak reactivity—it can change the physical properties in a big way, such as making derivatives more stable or less prone to breakdown. The presence of a bromine atom offers a handy anchor for organometallic transformations, plenty of which are now mainstays in pharmaceutical research.
I’ve talked with professionals who lean on this compound when striving to build more complex molecules. They see 4-Bromo-2,6-difluoropyridine as a modular building block that reduces the need for lengthy protection and deprotection steps. Synthesizing kinase inhibitors or crafting advanced agrochemical candidates often starts with choices like this one, since these atoms help modulate both the reactivity and potential bioactivity of target molecules.
Those who work in the pharmaceutical field often need starting materials that help them explore chemical space quickly. 4-Bromo-2,6-difluoropyridine checks that box. It’s got a reputation as a “plug-and-play” module in Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions. I’ve watched as synthetic chemists make careful choices about reagents, with conversations sometimes stretching on about the difference between bromo- versus chloro-pyridines. One noted that bromine sits in a sort of Goldilocks zone for leaving group ability—not so reactive that it causes instability, not so sluggish that it slows productivity.
Compared to its non-fluorinated or single-fluorinated cousins, 4-Bromo-2,6-difluoropyridine cuts down on unexpected side reactions. Having fluorines at both the 2 and 6 positions narrows the number of reaction possibilities, which helps avoid pitfalls in multi-step syntheses. This lower rate of side reactions means higher yields and more predictable scaling, something every chemist or production manager prizes.
In terms of appearance, 4-Bromo-2,6-difluoropyridine typically shows up as a crystalline solid, ranging off-white to beige, with a relatively low melting point. Experienced chemists value its decent shelf life under the right storage conditions—cool, dry, away from light or moisture—given that halogenated pyridines sometimes suffer from degradation.
Its solubility profile allows easy handling in common organic solvents, and its moderate volatility means it works well in a standard laboratory set-up. As anyone who has run cross-coupling reactions will tell you, the purity of starting materials makes or breaks a project, so most buyers stick to variants above 98% purity. This reliability offers some assurance when planning multi-step synthesis or scaling up from bench to pilot plant.
Ask a medicinal chemist where fluorinated pyridines show their worth, and you’ll hear stories about designing drug candidates that resist metabolic breakdown or have improved receptor selectivity. 4-Bromo-2,6-difluoropyridine features prominently in the assembly of scaffolds for kinase inhibitors, ion channel modulators, and antiviral drugs. Its special mix of bromine and fluorine let scientists produce key intermediates that, not so long ago, would have required multiple steps or would remain out of reach.
In the material science arena, the electronic effects of difluorination find a home in developing new organic semiconductors and advanced dyes. Some technologists pick this compound as a launching point for custom ligands or asymmetric catalysts, often combining it with other tricky building blocks. The overall trend seems clear: whenever tighter control or a boost in chemical stability is needed, researchers reach for 4-Bromo-2,6-difluoropyridine.
The knock-on effects even touch agrochemicals, where this compound’s framework helps strengthen the environmental stability of new herbicides or fungicides. Among regulatory teams working to develop safer, more selective pesticides, this molecule’s compact design and manageable reactivity win points over alternatives with bulkier or more reactive halogens.
Options abound for chemists choosing a pyridine derivative, but not all deliver the balance found here. Mono-halogenated pyridines, while sometimes cheaper, often bring reactivity profiles that miss the mark for certain coupling reactions. Di-fluoro but non-bromo options might lack the oxidative coupling utility that bromine provides.
Over my years in labs and conversations at chemical conferences, it’s clear that the best pyridine derivative depends on more than just cost or availability. Some chemists want to fine-tune pharmacokinetic properties, while others chase more efficient syntheses. Here, 4-Bromo-2,6-difluoropyridine wins out due to its ability to cover both needs without forcing compromises. It’s rare for a single compound to thread this needle, which helps explain its solid reputation among experts.
A good lab habit is to store halogenated pyridines in well-sealed vials, avoiding unnecessary exposure to moisture or extreme heat. Even stable compounds benefit from care and attention. From personal experience, running reactions with fresh, dry material consistently yields better results than using samples that have sat for months in an open bottle. Safety demands the usual gloves, goggles, and fume hood precautions due to possible skin and respiratory irritation.
Disposal calls for standard hazardous organic protocols, including collection and proper incineration, rather than pouring down the drain. The chemical’s profile calls for attention not just out of regulatory obligation, but also out of respect for fellow lab workers and the shared environment.
Those who synthesize complex molecules often mention how buying starting materials can make or break project timelines. Sometimes inconsistent supply or low purity leads to weeks of troubleshooting. Choosing a supplier with a track record for high-purity 4-Bromo-2,6-difluoropyridine solves plenty of these headaches.
Another issue crops up for those scaling up from milligrams to kilograms. Companies who prioritize thorough analytics and offer material with transparent impurity profiles save customers frustration with batch-to-batch variability. Some buyers now request supporting chromatograms or NMR data before committing to bulk orders. This trend places pressure on suppliers to maintain rigorous quality control, a net benefit for the whole industry.
On the application front, some chemists run into obstacles trying to balance reactivity and selectivity in coupling reactions. If a reaction proves unreliable, adjusting the base, solvent, or catalyst often works, but sticking with a compound like 4-Bromo-2,6-difluoropyridine, which features a consistent behavior profile, cuts down on optimization time.
The pursuit of new therapeutic agents hinges on the ability to quickly assemble and test chemical libraries. 4-Bromo-2,6-difluoropyridine’s property set supports fast, high-yield generation of candidate molecules through well-established reaction pathways. In many pharmaceutical labs, this means the difference between chasing dead ends or refining genuine leads with confidence.
The impact carries over into intellectual property strategies as well. Modifying an established drug scaffold with a hybrid of fluorine and bromine leads to new patentable compounds while retaining key activity or targeting features. Fluorinated motifs often resist metabolic breakdown in the body. Deliberate use of this pyridine variant gives research programs more options to compete in crowded therapeutic areas.
Even the most practical chemists know regulatory compliance cannot be ignored. Certain halogenated pyridines stir worry due to their environmental persistence or toxicity, yet 4-Bromo-2,6-difluoropyridine, due to its well-characterized breakdown profile and manageable hazard rating, wins approval among those charged with green chemistry initiatives. That doesn’t excuse lapses in waste management, but it does put minds at ease about making responsible choices during method development.
The fluorine atoms contribute to greater stability against some degradation pathways compared to non-fluorinated analogues; this translates to safer handling and storage, provided that the safety data is understood and followed. Some governments set tighter registration requirements for certain halogenated aromatics, so knowing the product’s regulatory standing in target markets saves time and legal headaches.
Between semiconductors, dyes, and specialty polymers, modern materials demand a level of chemical precision previous generations could only imagine. 4-Bromo-2,6-difluoropyridine supports this trend. Its twin fluorines tune the electronics, while bromine makes it a practical partner in creating extended pi-conjugated systems. These applications thrive in the hands of chemists who appreciate both the reactivity and stability of this scaffold.
Some of the most striking advances have come in organic light emitting diodes (OLEDs) and photovoltaic cells. Experts have explained how the deliberate placement of electron-withdrawing groups like fluorine, combined with a versatile bromine leaving group, opens up routes to new chromophores and charge-transport agents that weren’t feasible in the recent past. As materials science moves at speed, having building blocks like this one in hand becomes a strategic advantage.
The story of 4-Bromo-2,6-difluoropyridine points to a lesson: sometimes incremental changes—another halogen, a slightly different electronic feel—spark disproportionately large progress in science and technology. I’ve heard from startup founders and R&D consultants who say that access to compounds like this functions as a springboard into new research areas, whether that means streamlined drug development or breakthroughs in molecular electronics.
Ongoing innovation often relies on access to reliable, characterized building blocks. Any supplier who delivers consistent, high-purity material doesn’t just sell a chemical—they support all the quiet experiments, the trial-and-error, and the flashes of insight that drive modern discovery. For a synthetic chemist, the introduction of 4-Bromo-2,6-difluoropyridine isn’t just another molecule in the catalog: it’s a ticket to more robust pathways and a chance to cut through complexity.
Over time, I’ve noticed that the labs getting the most out of specialty chemicals aren’t necessarily the ones with the biggest budgets. Instead, they’re the ones who ask good questions up front: How does this compound differ from others on the market? Does the supplier provide authentic data and strong technical support? Can it be sourced in bulk without quality drops?
Communities of practice often share insights on these questions at conferences, in journal forums, and through informal networks. 4-Bromo-2,6-difluoropyridine emerges as a tool favored by seasoned chemists who value adaptability and reliability as much as novelty. Its blend of functional flexibility and structural simplicity creates opportunities that go beyond the usual “me-too” chemistry—paving the way for genuine progress both in the lab and in industry settings.
Working with 4-Bromo-2,6-difluoropyridine shows that advances don’t always come from complicated or glamorous sources. Sometimes it’s the quietly adaptable, purposefully designed modules that drive the next wave of scientific and commercial achievement. Its mix of bromine and fluorines opens doors in synthesis, tightens up research decision-making, and supports innovations in both pharma and materials science. That’s the kind of product that earns its place on any smart scientist’s shelf.
