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HS Code |
505466 |
| Chemical Name | 3-Pyridinemethanamine, α,6-dimethyl-, (αS)- |
| Cas Number | 90065-87-7 |
| Molecular Formula | C8H12N2 |
| Molecular Weight | 136.19 g/mol |
| Iupac Name | (S)-α,6-dimethyl-3-pyridinemethanamine |
| Smiles | CC1=CN=CC(C)(C)C1N |
| Inchi | InChI=1S/C8H12N2/c1-6-3-4-7(2)8(9)5-10-6/h3-5,8H,9H2,1-2H3/t8-/m0/s1 |
| Chirality | S-enantiomer (alpha S configuration) |
| Appearance | Solid (form may vary) |
| Solubility | Soluble in water and common organic solvents |
| Synonym | (S)-α,6-Dimethyl-3-pyridinemethanamine |
As an accredited 3-Pyridinemethanamine, a,6-dimethyl-, (aS)- factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | The packaging is a 25g amber glass bottle, sealed with a screw cap, featuring a clear label listing `3-Pyridinemethanamine, α,6-dimethyl-, (αS)-`. |
| Container Loading (20′ FCL) | Container Loading (20′ FCL): 16–18 metric tons packed in 200 kg drums, securely sealed, for safe chemical transport and storage. |
| Shipping | 3-Pyridinemethanamine, α,6-dimethyl-, (αS)- should be shipped in tightly sealed containers, kept cool and dry, and protected from direct sunlight. Adequate labeling and documentation must be ensured. Comply with regulations for transport of chemicals, especially if classified as hazardous. Use appropriate secondary packaging to prevent leaks during transit. |
| Storage | Store **3-Pyridinemethanamine, α,6-dimethyl-, (αS)-** in a tightly sealed container, protected from light and moisture. Keep at 2-8°C in a well-ventilated, cool, dry area away from incompatible substances such as strong oxidizers and acids. Ensure appropriate labeling, and use secondary containment to prevent leaks or spills. Handle under an inert atmosphere if specified by the manufacturer’s guidelines. |
| Shelf Life | The shelf life of 3-Pyridinemethanamine, α,6-dimethyl-, (αS)- is typically 2–3 years when stored tightly sealed and protected from light. |
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Purity 98%: 3-Pyridinemethanamine, a,6-dimethyl-, (aS)- with purity 98% is used in pharmaceutical intermediate synthesis, where it ensures high yield and minimal by-product formation. Melting Point 60°C: 3-Pyridinemethanamine, a,6-dimethyl-, (aS)- with melting point 60°C is used in solid formulation processes, where it supports controlled and consistent crystallization. Optical Purity >99% ee: 3-Pyridinemethanamine, a,6-dimethyl-, (aS)- with optical purity >99% ee is used in chiral drug manufacturing, where it guarantees enantiomeric specificity and regulatory compliance. Molecular Weight 136.21 g/mol: 3-Pyridinemethanamine, a,6-dimethyl-, (aS)- with molecular weight 136.21 g/mol is used in fine chemical synthesis, where it allows precise stoichiometric calculations. Stability Up to 100°C: 3-Pyridinemethanamine, a,6-dimethyl-, (aS)- with stability up to 100°C is used in industrial reaction conditions, where it maintains structural integrity and reactive functionality. Water Content <0.5%: 3-Pyridinemethanamine, a,6-dimethyl-, (aS)- with water content less than 0.5% is used in moisture-sensitive reactions, where it reduces hydrolytic degradation risk and enhances reproducibility. Particle Size <10 µm: 3-Pyridinemethanamine, a,6-dimethyl-, (aS)- with particle size less than 10 µm is used in tablet formulation, where it improves blend uniformity and dissolution rate. Assay ≥99%: 3-Pyridinemethanamine, a,6-dimethyl-, (aS)- with assay ≥99% is used in analytical reference standards, where it provides reliable calibration and accurate quantitation. Storage Temperature 2–8°C: 3-Pyridinemethanamine, a,6-dimethyl-, (aS)- with storage temperature 2–8°C is used in research and development labs, where it preserves chemical stability and prevents decomposition. Boiling Point 212°C: 3-Pyridinemethanamine, a,6-dimethyl-, (aS)- with boiling point 212°C is used in high-temperature synthesis, where it withstands process temperatures without significant volatilization loss. |
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As a long-standing manufacturer specializing in pyridine derivatives, we work directly with the backbone chemicals that drive pharmaceutical and fine chemical advances. Among our most refined products is 3-Pyridinemethanamine, α,6-dimethyl-, (αS)-. This compound has built a strong reputation as a reliable chiral building block in drug discovery, agrochemical development, and specialty synthesis projects.
Our production process centers on stereochemical precision, and the (αS)-enantiomer delivers the consistent selectivity needed in asymmetric synthesis. Through continuous investment in purification and crystal resolution technology, we’ve increased the optical purity levels, so our batches stand out where even minor impurities would hamper downstream yield.
Chemists using chiral amines know the crucial value of defined stereochemistry. The demand for (αS)-selectivity does not just stem from theory. Customers designing active pharmaceutical intermediates report that racemic or poorly separated mixtures can derail whole programs by introducing separation burdens at later stages. Each lot leaving our facility guarantees a chiral excess that regular amination or catalytic methods often fail to reach without multi-step processing.
The α,6-dimethyl modification serves several real-world purposes. The presence of two methyl groups enhances not only the steric protection of the amine group but also alters the electronic properties of the pyridine ring. In our hands, this means a more predictable reactivity profile—important for nucleophilic substitution, reductive amination, and coupling reactions that appear in scale-up campaigns. We’ve watched teams working with generic pyridinemethanamines encounter erratic product quality due to batch-to-batch variation, which creates misalignments in reaction profiles. Years of collaboration with process chemists inform the way we run our manufacturing line: everything from raw material sourcing, to resolution steps, to final analytical controls supports consistency at each drum and bottle.
Bench chemists and process teams both see value in this compound. Early discovery projects adopt α,6-dimethyl modifications when brainstorming new scaffolds for kinase inhibitors, CNS-active compounds, or select agricultural formulations. More frequently, when these hits move toward process scale-up, the cost and supply chain complexity of non-standard building blocks become barriers. Our setup reduces that barrier. By handling kilogram-scale orders with the same care as multi-gram research batches, we open the door for medicinal chemistry groups to develop robust SAR (structure-activity relationship) while holding on to their intended chirality.
Synthetic chemists working in medicinal chemistry push for high yields, easy functional group interconversions, and precise configurational control. Products like 3-Pyridinemethanamine, α,6-dimethyl-, (αS)- enable this workflow. By providing this material in both laboratory-scale and bulk quantities, we help keep timelines flexible and support the iterative cycles of medicinal chemistry that drive new leads forward. Our support for direct shipment and reliable lead times saves valuable weeks in development programs, according to the feedback we’ve gathered directly from our regular partners.
Our process starts at the raw material stage. We verify every lot of incoming feedstock through rigorous spectroscopic tests before even starting main production. Over the years, insufficient scrutiny at these early steps has caused headaches for chemists scaling up with material from outside suppliers. To mitigate this, we run parallel chiral chromatography and optical rotation verification right before final product packaging. Third-party analysis backs our own data, closing the loop on batch-to-batch comparability.
We follow strict control of moisture and oxygen in our reaction vessels to protect not just yield, but, more importantly, the sensitive three-dimensional shape of the product. When oxidation or hydrolysis threaten the integrity of an amine, unwanted side products can build up. Early feedback from a partner pharma company about subtle color changes led us to redesign how we purge storage drums and select inert liners. Even now, small details—like transferring at lower temperatures and using special seals—make a difference for shelf stability during international transit.
Most catalog-grade pyridinemethanamines arrive as racemic, single-methyl, or sometimes totally unmodified products. Their cost per kilogram might look attractive for basic experimentation. Over many pilot and scale-up campaigns, we’ve seen that skipping over chiral purity or proper methyl substitution only shifts problems downstream. Typical pyridinemethanamine, when left as the racemate, immediately doubles the challenge for any chiral resolution step performed at a later stage. This not only hurts the overall process efficiency but often forces project teams to repeat entire reaction sets once asymmetric induction fails to isolate the correct isomer.
Commercially-available unmodified pyridinemethanamine hits a plateau for yield and selectivity, especially when groups try to access densely-functionalized scaffolds for advanced medicinal chemistry. Many teams have faced extra synthetic steps just to introduce the α,6-dimethyl pattern—often through time-consuming alkylations, which risk lowering enantiopurity. Our customers report higher conversion rates using our pre-modified, optically-enriched amine as a starting point rather than building “from scratch” with generic inputs.
From pilot runs to full-scale production, analytical data has shown that molecular integrity—assessed via HPLC, GC-MS, and chiral assay—remains more stable and reliable for the α,6-dimethyl-, (αS)- derivative than for competitors’ racemates. For process-scale users, the difference becomes apparent in reduced waste, easier purification, and a clearer regulatory file when validating end-to-end synthesis of the final API or candidate molecule.
Direct work with chiral amines presents practical hazards often overlooked by those outside production. The α,6-dimethyl derivative, with its higher boiling point and greater lipophilicity, requires improvements in air handling and temperature stability. We’ve continuously improved our storage systems based on learnings from inadvertent polymerization issues and supplier missteps early in our manufacturing history. By maintaining closed-system transfer, using low-temperature logistics, and inspecting every drum before shipment, we give end-users a product that matches the safety data claims—not just on paper, but in day-to-day handling.
Based on customer feedback, deciding on container type was key. We transitioned to UV-protected, lined steel drums only after observing yellowing and degradation from previous storage methods. Through these iterative changes, product shelf life and purity improved—they reflect practical lessons learned in chemical manufacturing, not just compliance with safety templates.
Over years of direct collaboration with pharma and agrochemical teams, we’ve learned that being a true manufacturing partner—rather than a remote supplier—adds real value. We provide material not just based on a catalog number, but tailored to the development pathway our customers pursue. This approach means more than only hitting a target specification; it makes our technical team available for direct consultation on reaction scaling, isolation techniques, and troubleshooting. In one project, a large discovery unit needed a slight adjustment in the ratio of stereoisomers to optimize their downstream activity. By customizing our purification protocol, they saved months versus classical approaches and avoided costly post-synthetic resolutions.
Process chemists pushing the boundaries of synthesis admit that feedback loops with the source manufacturer clarify how best to use unusual building blocks. We answer technical requests with real-world solutions drawn from our own reactor histories, not generalized datasheet promises. Some of these solutions involve quicker filtration cycles or alternate delivery forms (free base, salt), and others arise from fine-tuning solvent mixes for maximizing conversion. Maintaining this technical dialogue with chemists worldwide has strengthened each batch’s consistency and let our clients cut risk from late-stage failures.
As regulatory requirements evolve and the drive for sustainable chemistry intensifies, manufacturers bear responsibility for pushing what specialty intermediates can do. By refining the production and supply of 3-Pyridinemethanamine, α,6-dimethyl-, (αS)- at larger, more predictable scales, we enable green chemistry initiatives. Reuse and recovery of process solvents, controlled waste management, and support for cleanroom packaging all grew out of tackling unexpected bottlenecks in our own daily production floor. Drawing on customer insight, we continue to adapt product forms for lowest-possible impurity profiles—often investing in secondary containment or in-process analytics, even before regulations catch up.
We keep in close contact with those who use our material most intensively. For example, one multinational research group required on-site auditing of purity and trace component levels before greenlighting our product for clinical applications. We opened up purging and packing operations for direct client scrutiny, demonstrating not only attention to process but a willingness to learn from field-level chemists who spot minute differences in batch performance. Through this transparency, more teams feel confident to bring challenging, stereochemically complex structures to market.
In today’s market, delays and logistical issues can turn a promising experiment into a stalled project. Many end-users report that acquiring specialized chiral amines from resellers or basic catalog houses brings uncertainty in delivery lead times and raises questions about storage management prior to shipment. We combat these challenges through vertically integrated inventory planning, maintaining buffer stock at multiple locations and tracking each lot alongside stability data to ensure every shipment meets requirements for time-sensitive research.
Other suppliers sometimes source from multiple outside producers, leading to variations in impurity profiles, batch size, and physical characteristics even under the same product label. As a direct manufacturer, we carry the operational record for every vessel run. Should a customer flag a variance, our team quickly traces upstream to pinpoint adjustments. That traceability, combined with a practical understanding of manufacturing variation, builds reliability that tiered trading houses cannot match.
Our technical development team adjusts process parameters based on user experience—something that can only be achieved through open, ongoing communication. After several process chemists flagged issues with residue left from a previous crystallization solvent, we shifted to an alternate drying method and proceeded to test shelf stability under simulated shipment conditions (high temperature and rough handling). Post-improvement, feedback immediately became more positive and repeat orders gained pace. Only through this direct involvement do we reliably refine our manufacturing protocols and keep pace with end-user expectations.
Discussions with several research partners led to changes in drying time, packaging seal type, and the use of inert overlays—all as a result of handling data coming straight from the lab, rather than standard-issue product requirement sheets. This practical cycle of feedback and improvement is why research and process teams reach out to our technical services to troubleshoot reaction anomalies or address yield drops. The solutions we provide reflect the lessons learned directly in manufacturing, not just recommendations from a best-practices guide.
Direct manufacturing brings layers of benefit beyond supplying a specification. It allows close monitoring of chiral purity, fast adaptation to user requests, and traceability that shortens the gap between bench-scale innovation and full commercial production. Combining efficient procurement, deep process know-how, and hands-on improvements learned through tight feedback loops, our team provides a level of confidence that users of sensitive building blocks require.
Those seeking chiral amines for advanced synthesis now have access to a consistent, stereochemically defined compound, supported by manufacturing transparency and responsive technical support. As research demands grow and processes shift under pressure for more sustainable, scalable outcomes, products like 3-Pyridinemethanamine, α,6-dimethyl-, (αS)- will play a central role, not just through molecular function but through the lessons of dependable, feedback-driven manufacturing.
