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HS Code |
677393 |
| Chemical Name | 3-Hydroxypyridine-N-oxide |
| Molecular Formula | C5H5NO2 |
| Molecular Weight | 111.10 g/mol |
| Cas Number | 1003-22-1 |
| Appearance | White to off-white crystalline powder |
| Melting Point | 121-124°C |
| Solubility In Water | Soluble |
| Purity | Typically ≥98% |
| Storage Temperature | Room temperature |
| Smiles | c1cncc(c1O)N(=O) |
| Inchi | InChI=1S/C5H5NO2/c7-5-2-1-3-6(8)4-5/h1-4,7H |
| Pka | 8.52 |
| Synonyms | 3-Pyridinol N-oxide |
As an accredited 3-Hydroxypyridine-N-oxide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 3-Hydroxypyridine-N-oxide is supplied in a 25g amber glass bottle with a secure screw cap, labeled with safety and chemical information. |
| Container Loading (20′ FCL) | Container Loading (20′ FCL) for 3-Hydroxypyridine-N-oxide involves securely packing 8–10 MT in sealed, moisture-proof drums for safe shipment. |
| Shipping | 3-Hydroxypyridine-N-oxide is shipped in tightly sealed containers to prevent moisture absorption and contamination. The chemical is packaged according to regulatory standards for safe transport, typically as a solid under ambient conditions. Proper labeling, hazard information, and handling instructions are included to ensure compliance with relevant safety guidelines during shipping. |
| Storage | 3-Hydroxypyridine-N-oxide should be stored in a tightly closed container, in a cool, dry, and well-ventilated area, away from sources of heat, ignition, and incompatible substances such as strong oxidizers. Avoid exposure to moisture and direct sunlight. Ensure proper labeling and keep the chemical separated from food and drink. Use appropriate personal protective equipment when handling the substance. |
| Shelf Life | The shelf life of 3-Hydroxypyridine-N-oxide is typically 2-3 years when stored in a cool, dry, and tightly sealed container. |
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Purity 99%: 3-Hydroxypyridine-N-oxide with purity 99% is used in pharmaceutical synthesis, where it ensures high yield and minimal by-product formation. Molecular weight 111.10 g/mol: 3-Hydroxypyridine-N-oxide of molecular weight 111.10 g/mol is used in organic chemistry research, where it facilitates predictable reaction stoichiometry. Melting point 147–151°C: 3-Hydroxypyridine-N-oxide with a melting point of 147–151°C is used in solid-state formulation studies, where it guarantees thermal stability during processing. Particle size <50 μm: 3-Hydroxypyridine-N-oxide with particle size below 50 μm is used in catalyst manufacturing, where it promotes uniform dispersion and reactivity. Stability temperature up to 160°C: 3-Hydroxypyridine-N-oxide stable up to 160°C is used in high-temperature organic reactions, where it maintains structural integrity and consistent performance. Aqueous solubility 120 g/L: 3-Hydroxypyridine-N-oxide with aqueous solubility of 120 g/L is used in bioconjugation processes, where it provides efficient dissolution and homogeneous reaction conditions. UV absorption λmax 323 nm: 3-Hydroxypyridine-N-oxide with UV absorption at 323 nm is used in analytical method development, where it enables precise quantification and detection sensitivity. |
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Discovering the right specialty chemical can change outcomes in research or manufacturing. Over the years, I’ve seen how one well-chosen compound separates promising trials from persistent setbacks. Take 3-Hydroxypyridine-N-oxide—not just another chemical on the shelf, but a compound that has earned respect among scientists and engineers. Its molecular structure, with the pyridine ring and the unique N-oxide functional group, offers a blend of reactivity and stability. This combination isn’t easily replaced or mimicked by other similar substances.
In my time in both industrial and academic labs, I came across plenty of reagents that left me wishing for something better. Either purity levels were inconsistent, or results jumped all over the place. 3-Hydroxypyridine-N-oxide (3-HOPO) kept performing, batch after batch. Offered in crystalline or powder form, typical models carry a purity guaranteed above 98%, supported by chromatographic analysis and spectral data. Chemists appreciate this level of quality—the kind that makes protocol planning less stressful and lets experimentation shift focus from “does the chemical work?” to “what can I actually learn here?”
In a crowded field of heterocyclic compounds, 3-HOPO stands out for more than its technical metrics. I’ve worked with similar nucleophilic agents, and few deliver such dependable reactivity in oxidative systems. Its N-oxide group offers selectivity in redox and catalysis experiments that regular pyridines just can’t match. When synthesizing compounds that demand gentle yet efficient oxidation, other oxidizing agents often go too far, damaging sensitive motifs or piling on unwanted byproducts. 3-HOPO threads that needle, balancing reactivity with control. It’s one of the few N-oxides that’s kept a permanent spot in my reagent drawer for that reason.
Application drives value for any chemical, and 3-HOPO draws researchers and process engineers for multiple reasons. In analytical labs, its ability to influence oxidative pathways makes it a go-to agent for functional group transformations, especially when dealing with pharmaceuticals or specialty intermediates. For synthetic chemists, its action as a mild oxidant opens doors for reactions where harsher conditions would ruin the product—like selective oxygen insertion or dehydrogenation, avoiding the mess left by stronger peroxides or permanganates. It doesn’t just shine in organic chemistry, either. Metallurgists and material scientists use it to tweak electron configurations in complex ions, altering magnetic or optical properties for sensors or new materials.
Having ordered hundreds of grams of lab reagents over the years, I know the headache when purity claims don’t pan out. Lot-to-lot traceability and analytical transparency matter more than ever. Most reputable versions of 3-HOPO bring full NMR spectra, HPLC reports, and sometimes IR profiles. Every bottle includes batch numbers and certificates—features that actually matter when results rest on tiny differences. For those in regulated sectors, reproducibility secures both trust and compliance. Nobody wants surprises when running multi-stage synthesis at scale.
Here’s where experience helps. Many labs fall back on traditional pyridine-N-oxide or isomers like 2- or 4-hydroxy variants, figuring they’ll get the same effect. In practice, subtle shifts in the chemical structure of 3-HOPO provide significant advantages. During reaction planning, that third position hydroxyl opens up unique hydrogen bonding or activation pathways. With 2- or 4-substituted isomers, steric effects or electronic distribution just isn’t the same, and yields can drop off. Some alternatives might push a reaction too far or fail to deliver the desired selectivity, especially in delicate multi-step syntheses. I’ve seen teams lose days reworking plans simply because they expected “close enough” reagents to behave like 3-HOPO.
Nobody enjoys dealing with a reagent that degrades too quickly or leaves a residue impossible to remove. 3-HOPO stores well under standard dry, cool conditions, with no need for cryogenic cooling or exotic containers. Its low volatility cuts down loss during weighing, and the compound’s crystalline nature allows for accurate dosing. In my experience, even after months tucked away, a freshly opened bottle behaves just as expected, without the caking or clumping you see in more hygroscopic substances.
Safety can’t wait until something goes wrong. From thousands of bench hours, I know how important it is to have reliable safety data. 3-HOPO doesn’t carry the acute toxicity risks of stronger oxidants or heavy metal complexes, though like most chemicals, it asks for gloves and goggles—common-sense rules in the modern lab. Its safety profile aligns with routine lab operations, no need for extensive containment or evaporation control in typical procedures. Lab staff and operators appreciate working with compounds that don’t amp up daily risk.
Many successful projects owe progress to reagents that go unnoticed behind the scenes. 3-HOPO found a home in the synthesis of anti-inflammatory candidates, selective materials for battery research, or oxidation protocols where high-value APIs required careful touch. The difference it brings comes down to reliability and adaptability. Modern research often involves multi-disciplinary teams: chemists, engineers, biologists, each with unique needs. Having a standard like 3-HOPO means less time revalidating methods, more time solving bigger challenges.
Any researcher can share a story of chasing down elusive technical support, or deciphering product specs in a foreign language. Trusted suppliers offering 3-Hydroxypyridine-N-oxide usually back purchases with solid documentation: not just technical sheets, but clear synthesis pathways, impurity profiles, and safety reports. This helps avoid costly guesswork in method development or troubleshooting. When I was scaling reactions from milligram test tubes to pilot plant volumes, fast access to robust documentation kept productivity high–and fewer headaches for everyone.
Some chemicals seem fine on paper, but in practice every lot brings a surprise. Through years of scale-up and benchmarking, I found 3-HOPO stands out for reproducibility. From undergraduate teaching labs to contract manufacturing plants, users welcome that kind of consistent quality. In research, reliable tools mean more than convenience—they shape everything from publication timelines to regulatory approval. As research budgets tighten, there’s less appetite for chasing down erratic supply issues.
Sustainability and environmental safety move to the forefront through research agendas and consumer demand. 3-HOPO, thanks to its moderate reactivity and manageable handling, plays a role in greener protocols. Researchers seeking lower E-factor (mass of waste per mass of product) often opt for milder oxidants to minimize byproducts and ease wastewater treatment. While not a “green” chemical by strict standards, its use in efficiency-driven synthetic routes can help reduce solvents, waste, and time. From my own lab days, efforts to replace hazardous legacy oxidants led our team to more sustainable, scalable processes—3-HOPO contributed to several wins in those projects.
Intellectual property matters in both academic and industrial innovation. The unique reactivity of 3-Hydroxypyridine-N-oxide opens doors for novel reaction pathways or optimized formulations that wouldn’t be possible with more common N-oxides. Teams working on specialty pharmaceuticals, agrochemicals, or catalytic processes often leverage the compound’s selectivity as a patentable edge. I’ve watched project groups file claims for improved yields or safer synthesis routes where this molecule played a vital, enabling role.
Hands-on experience gives future chemists a stronger foundation. Instructing undergraduate and graduate labs, I favored 3-HOPO for its recognizable reaction behavior. Unlike pyrophoric or highly toxic reagents, it allows students to engage with meaningful transformations without excessive risk. Faculty find comfort in a compound that delivers consistent educational results—students can focus on concepts, not complications from unpredictable chemicals. Once students experience straightforward isolation, analysis, and confirmation, their confidence in advanced organic techniques grows.
3-Hydroxypyridine-N-oxide dissolves easily in water, alcohols, and some polar organic solvents. This range gives process chemists flexibility—less time wrestling with exotic solvent systems, more room to optimize yields. Compatibility with standard glassware and laboratory plastics lets staff avoid specialist treatments or worry over unwanted interactions. In industrial workflows, these qualities translate to smoother reaction planning, less variability between batches, and reduced downtime.
Recent events reminded the world how fragile supply chains can be. In research and manufacturing, sourcing reliable specialty chemicals is never trivial. Most suppliers of 3-HOPO have established distribution channels and keep substantial inventory, so researchers enjoy short lead times and predictable restocking. These benefits support pilot projects, regulatory filings, or large-scale process development that can’t wait weeks for a critical raw material. By building on longstanding supplier relationships, organizations navigate global uncertainties more effectively.
Looking back at diverse applications, the real measure of any specialty reagent is how well it solves problems in the real world. From fine chemicals to pharmaceuticals to materials science, 3-HOPO earned trust by outperforming alternatives in targeted oxidation and catalytic applications. Not every chemical delivers on paper promises, but repeated use in published literature and industry practice shows real-world results shape demand more than marketing claims. I’ve seen entire synthetic schemes redesigned for better environmental compliance or higher throughput, all because the right N-oxide proved both effective and manageable.
No chemical is perfect, and open dialogue between users and manufacturers can drive improvements. In my experience, researchers want options for particle size, packaging material, and concentration. Some may prefer solutions or premixed forms to cut down prep steps and minimize dust exposure. Suppliers listening to those practical details strengthen long-term partnerships. Sustainable sourcing of raw materials and greener manufacturing protocols remain on many clients’ wishlists as industry shifts toward climate responsibility.
Daily touchpoints with this product taught me several lessons. Always check compatibility of the planned reaction media, especially with sensitive co-reagents or catalysts. Store containers in airtight conditions and weigh out portions using clean, dry instruments—this safeguards purity across uses. Clear labeling and separation from strong acids or reducing agents simplify workflow and prevent accidental cross-reactions. When scaling up, plan pilot runs to fine-tune variables, since even robust chemicals show quirks at larger volumes. Open communication with technical support can speed up troubleshooting and turn setbacks into smooth scale-ups.
It’s tempting to treat chemical purchases as generic commodities, but the experience behind a product shapes its reputation. I’ve watched expert panels and technical reviewers comment not just on published specs, but on hands-on results—yields, reproducibility, ease of cleanup, impact on downstream processing. 3-HOPO scores highly in these conversations, often cited for its role in enhancing both efficiency and learning. Word of mouth among colleagues and mentors carries as much impact as polished technical brochures.
Emerging research into green synthesis, renewable energy, and precision medicine signals growing demand for selective reagents. As more teams combine data-driven modeling with live experimentation, the need for trusted foundational reagents only grows. 3-HOPO holds a strong position on the bench and in the process line, making it an attractive option for anyone charting the next advances in their field. Its value comes from years of proven results, real-world adaptability, and responsive supply.
Every project I've joined or managed weighed cost, reliability, and safety of reagents. 3-HOPO offers a practical solution for chemists and engineers seeking mild, consistent oxidation—without the headaches of more aggressive chemicals. Its documented quality, established track record, and broad compatibility put it a step ahead of similar products. If you're refining synthetic methods, developing new materials, or educating future scientists, building on the strengths of 3-Hydroxypyridine-N-oxide makes sense for both experienced professionals and newcomers taking on their first research challenges.
