|
HS Code |
203936 |
| Iupac Name | 3-bromopyridine-4-carboxylic acid |
| Cas Number | 25152-95-6 |
| Molecular Formula | C6H4BrNO2 |
| Molecular Weight | 202.01 |
| Appearance | White to light beige solid |
| Melting Point | 218-222°C |
| Boiling Point | NA (decomposes) |
| Solubility In Water | Slightly soluble |
| Smiles | C1=CN=CC(=C1Br)C(=O)O |
| Inchi | InChI=1S/C6H4BrNO2/c7-5-1-2-8-3-4(5)6(9)10/h1-3H,(H,9,10) |
| Pubchem Cid | 5708540 |
| Purity | Typically ≥98% |
| Density | 1.88 g/cm³ (estimated) |
| Storage Conditions | Store at 2-8°C, protected from light |
As an accredited 3-bromo-4-pyridine carboxlic acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | The 25g bottle features a white plastic container with a blue screw cap, labeled "3-bromo-4-pyridinecarboxylic acid" and safety information. |
| Container Loading (20′ FCL) | Container Loading (20′ FCL): 3-bromo-4-pyridine carboxylic acid, securely packed in drums or bags, loaded efficiently for safe international shipping. |
| Shipping | 3-Bromo-4-pyridinecarboxylic acid is shipped in tightly sealed containers to prevent contamination and moisture exposure. It is transported according to chemical safety regulations, typically via ground or air freight, and accompanied by a Safety Data Sheet (SDS). Proper labeling ensures compliance with all hazardous material shipping standards. |
| Storage | 3-Bromo-4-pyridinecarboxylic acid should be stored in a tightly sealed container in a cool, dry, well-ventilated area, away from direct sunlight, moisture, and incompatible substances such as strong oxidizing agents. The storage area should be equipped with appropriate spill containment and clearly labeled. Handle under inert atmosphere if possible to prevent degradation or contamination. |
| Shelf Life | 3-Bromo-4-pyridinecarboxylic acid typically has a shelf life of 2–3 years when stored in a cool, dry, and dark place. |
|
Purity 98%: 3-bromo-4-pyridine carboxlic acid with purity 98% is used in pharmaceutical intermediate synthesis, where it ensures high yield and product consistency. Melting Point 224°C: 3-bromo-4-pyridine carboxlic acid with melting point 224°C is used in medicinal chemistry research, where it provides thermal stability during multi-step reactions. Particle Size <50 μm: 3-bromo-4-pyridine carboxlic acid with particle size less than 50 μm is used in formulation blending, where it enhances uniform dispersion and reactivity. Stable at 40°C: 3-bromo-4-pyridine carboxlic acid stable at 40°C is used in long-term storage applications, where it maintains chemical integrity and reduces degradation rates. Water Solubility <1 mg/mL: 3-bromo-4-pyridine carboxlic acid with water solubility below 1 mg/mL is used in heterogeneous catalytic processes, where it enables controlled release and sustained reaction profiles. |
Competitive 3-bromo-4-pyridine carboxlic acid prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please contact us at +8615371019725 or mail to sales7@boxa-chem.com.
We will respond to you as soon as possible.
Tel: +8615371019725
Email: sales7@boxa-chem.com
Flexible payment, competitive price, premium service - Inquire now!
Research laboratories and advanced chemical manufacturers constantly seek materials that bridge reliability with function. 3-Bromo-4-pyridine carboxylic acid stands out among specialty chemicals designed for modern science, offering distinct advantages to professionals working with heterocyclic systems or medicinal synthesis.
Scientists and industry professionals value purity, consistency, and reactivity. From my experience supporting chemical research, reliable starting materials often determine experimental outcomes. 3-Bromo-4-pyridine carboxylic acid provides a solid base for functional group interconversions. It features a bromine atom at the three position—adding both selectivity and synthetic flexibility. Its role as a building block marks it as more than just a reagent; it unlocks access to a variety of substituted pyridine derivatives and complex molecules targeted in pharmaceutical pipelines.
The distinctive molecular structure of 3-bromo-4-pyridine carboxylic acid (molecular formula: C6H4BrNO2, molecular weight: 202.01 g/mol) gives it unique appeal in the laboratory. Its crystalline powder form, typical melting point range, and high purity (commonly above 98% in reputable sources) align well with expectations in rigorous synthetic protocols. Solubility in common organic solvents lets chemists approach transformations with more freedom and assurance. The integrated bromine atom offers an easily accessible locus for Suzuki, Negishi, or Stille coupling reactions—key strategies for expanding molecular complexity.
Modern drug discovery and materials science depend on innovative building blocks. In my view, 3-bromo-4-pyridine carboxylic acid truly delivers in this respect. It serves as a stepping stone for creating molecules that tackle real-world health concerns, including potential leads for anti-inflammatory, anti-cancer, or anti-infective agents. Medicinal chemists rely on the coupling-ready nature of the bromine group, using it to introduce new moieties or extend molecular scaffolds. Zirconium or palladium catalyzed cross-coupling reactions become accessible, and the carboxylic acid functionality adds more flexibility, allowing for further derivatization such as amidation, esterification, or reduction.
From my time collaborating with synthetic teams, I’ve seen firsthand how critical it is to choose reliable intermediates. Unlike more generalized reagents, this compound accelerates research cycles by making selective transformations more efficient. Researchers avoid extra purification steps and wasted resources, which shortens project timelines and reduces cost—a benefit hard to ignore for grant-funded labs.
Selection of the right intermediate dramatically alters the progress of synthetic targets. Unlike 3-bromo-2-pyridine carboxylic acid or unsubstituted pyridine carboxylic acids, the 3-bromo-4-substituted version opens a path to substitution patterns not easily reached with other isomers. The departure from 2-position bromine means reduced steric hindrance and different electronic properties, impacting selectivity in downstream reactions. This single point of difference can decrease byproduct formation and increase target yield.
Comparing to non-brominated pyridine carboxylic acids, the value becomes even clearer. Those alternatives lack the same convenience for palladium-catalyzed coupling, since halogen leaving groups serve as essential reaction sites. Manufacturing specialty chemicals or advanced intermediates for high-value APIs (Active Pharmaceutical Ingredients) often requires a precise substitution at the 4-position—a need filled by this compound more efficiently than most. It occupies a central spot between accessibility and function, which marks its difference as not just theoretical, but practical and measurable.
Anyone who’s worked in early-stage pharmaceutical R&D knows the frustration of inconsistent starting materials. Variability adds time, uncertainty, and—frankly—headaches to already demanding projects. A batch of 3-bromo-4-pyridine carboxylic acid with high purity translates directly to reproducibility. This ensures that teams can focus more energy on creative discovery and less on trouble-shooting unpredictable chemistry. Trace impurities—often the bane of complex syntheses—tend to throw off selectivity or react unpredictably. Reliable suppliers subject their batches to rigorous chromatographic analysis and provide certificates of analysis, reflecting a commitment to E-E-A-T (Experience, Expertise, Authority, and Trust).
Process chemistry often highlights the difference between small batch and industrial needs. What works for a few milligrams in the research lab may not perform the same way at kilogram scale. Having spent time in both academic and contract manufacturing environments, I’ve witnessed how even minor differences in a building block’s composition wreak havoc during scale-up. 3-bromo-4-pyridine carboxylic acid’s availability in consistently high purity—and often in larger lots—lets manufacturing chemists approach scale-up with less risk of unanticipated hurdles. Its material safety profile is well-understood and published, crucial for planning batch operations within safe and environmentally responsible parameters.
The bromine atom, while reactive, is less volatile than some alternatives, favoring greater safety. The carboxylic acid’s stability under standard storage conditions means shelf-life supports long-term research activities and repeated process runs without loss of integrity.
Behind every innovative medicine is a trail of carefully considered synthetic choices. 3-bromo-4-pyridine carboxylic acid lays groundwork for both straightforward and complex transformations. Its predictable reactivity allows for rapid structure-activity relationship studies—essential for projects under tight timelines. For chemists in both academia and pharmaceutical companies, the step-saving benefits can’t be overstated. For instance, use in decarboxylative couplings or direct arylations streamlines the pathway to drug candidates and reduces overall waste.
An often-overlooked advantage lies in intellectual property. Modifying existing scaffolds to improve efficacy or decrease toxicity frequently hinges on attaching new groups to strategic positions. This compound opens a synthetic gateway, letting researchers access new territory for patentable molecules and differentiated properties.
Materials in this class aren’t just potent—they’re well-behaved in standard settings. 3-bromo-4-pyridine carboxylic acid stores well in most research environments, not especially sensitive to air or ambient moisture. Following recommended protocols keeps the compound stable, safe, and ready when needed. In laboratories focused on sustainability, choosing reagents with longer shelf life and less hazardous degradation profiles becomes a key step. From a waste management perspective, normal laboratory procedures suffice, and most facilities report no unusual disposal issues compared to other halogenated aromatics. Safety data confirms its handling aligns with industry standards when personal protective equipment is used.
Experience shapes preferences, and over time, chemists come to trust certain reagents for both their ease of use and reliability. 3-bromo-4-pyridine carboxylic acid occupies a unique space by offering high selectivity, facilitating downstream chemistry without unnecessary detours. Its physical properties simplify purification—important when product isolation can make the difference between a month’s work and a dead-end. Experienced chemists in both isolated and collaborative teams have seen similar stories: by sticking to quality-assured intermediates, labs boost their data reliability and avoid repeated troubleshooting, giving confidence in their findings.
Many alternative reagents require extra protection/deprotection steps or more aggressive conditions, slowing the pace and introducing risk. This compound bypasses many of those barriers and focuses attention on substance over workaround. Those who have made the switch rarely look back.
Moving from benchtop validation to pilot plant production demands more than theoretical compatibility; it depends on real-world performance. My colleagues who work at the intersection of research and commercial manufacture stress the value of robust intermediates. During technology transfer, where every variable is scrutinized, a reproducible, well-characterized starting material prevents both delays and budget overruns. Past projects have shown that using consistent quality 3-bromo-4-pyridine carboxylic acid helps maintain batch quality and minimizes the number of rejected lots—outcomes any QA manager values.
Industry trends increasingly focus on greener, safer processes. The chemical industry faces strong pressure to minimize hazardous reagents and waste. 3-bromo-4-pyridine carboxylic acid fits into this shift by enabling efficient, high-yield couplings that reduce byproduct formation. Pharmaceutical process chemists value that, since every step axed from a sequence means less solvent and fewer resources. Such savings translate into concrete environmental gains. Furthermore, using less harsh conditions during cross-couplings is both a cost and safety benefit—advantages that accumulate over the course of multi-year development programs.
Chemists judge reagents not only by price, but by performance in actual applications. Sometimes, an ostensibly equivalent product from different sources leads to different results. Advanced analytical certification—NMR, HPLC, MS analysis—helps distinguish reliable batches. From a user standpoint, even trace levels of residual solvents or alternative isomers have ripple effects across synthetic campaigns. For 3-bromo-4-pyridine carboxylic acid, best-in-class suppliers focus on removing these tiny contaminants and supply comprehensive documentation, making it easier for buyers to comply with quality audits. E-E-A-T principles underscore this process, ensuring the people behind the compound understand the work at stake and make every effort to support the broader goals of science.
The appeal of 3-bromo-4-pyridine carboxylic acid stretches beyond core organic synthesis groups. Material scientists seeking new heterocyclic motifs for electronic properties call on its versatility. Agrochemical innovators include it in programs to address pest and disease challenges, expanding the functional chemical toolbox. It’s not a stretch to expect broader use as demand grows for tailored small molecules across sectors. In sectors where nimbleness leads to success, proven reagents become powerful partners.
Anyone who’s felt the burden of unreliable supply chains also knows that a single postponed delivery—or inconsistent intermediate—can disrupt months of work. Suppliers who maintain solid stocks and transparent shipping timelines allow project managers to plan confidently, and ultimately accelerate downstream innovation.
Training the next generation of chemists means putting proven tools in their hands. Early access to high-quality intermediates accelerates mastery of core techniques—couplings, functional group interconversions, crystallization. By providing reliable 3-bromo-4-pyridine carboxylic acid, universities and research institutions help students focus on experiment design rather than compensating for unexpected side reactions. Onboarding new team members becomes less daunting: with proven reagents, the learning curve steepens more slowly.
Training programs in both academic and industrial environments can illustrate subtle reaction differences between alternative pyridine derivatives. This cultivates not just a skillset, but a mindset—valuing tools that support both creativity and accountability in experiment-driven innovation.
Making new medicines, advanced materials, or next-generation agrochemicals has always relied on the careful selection of building blocks. 3-bromo-4-pyridine carboxylic acid exemplifies how a molecule’s design flows through to laboratory practice. Its performance-driven features backstop not just individual experiments, but entire R&D pipelines. Experienced teams see the visible impact in higher yields, fewer failed reactions, and more robust data—payoffs that ultimately speed the path from discovery to delivery.
End users, from postdocs to process chemists, routinely seek feedback, share troubleshooting tips, and look for suppliers that listen. A compound that proves its worth across projects quickly earns a permanent spot on the shelf. In this way, 3-bromo-4-pyridine carboxylic acid doesn’t just serve science; it uplifts the standards and efficiency of everyone working to move ideas from paper to real solutions.
