|
HS Code |
477261 |
| Chemical Name | 3-Bromo-2-hydroxypyridine |
| Molecular Formula | C5H4BrNO |
| Molecular Weight | 173.00 g/mol |
| Cas Number | 18368-36-6 |
| Appearance | Light yellow to beige solid |
| Melting Point | 58-62°C |
| Purity | Typically ≥98% |
| Solubility | Soluble in organic solvents such as DMSO and methanol |
| Smiles | C1=CC(=C(N=C1)O)Br |
| Storage Conditions | Store at room temperature, tightly closed, in a dry place |
| Synonyms | 3-Bromo-2-pyridinol; 3-Bromo-2-hydroxypyridine |
As an accredited 3-Bromo-2-hydroxypyridine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Amber glass bottle containing 25 grams of 3-Bromo-2-hydroxypyridine, tightly sealed with a screw cap, and labeled with hazard information. |
| Container Loading (20′ FCL) | 3-Bromo-2-hydroxypyridine is typically packed in 25kg fiber drums, filling a 20′ FCL with about 9–10 metric tons. |
| Shipping | 3-Bromo-2-hydroxypyridine is shipped in sealed, airtight containers to prevent moisture absorption and contamination. It is handled as a hazardous chemical, requiring proper labeling and documentation according to regulatory standards. Shipping typically follows UN/DOT regulations, ensuring safe transport and compliance with local, national, and international chemical safety guidelines. |
| Storage | 3-Bromo-2-hydroxypyridine should be stored in a tightly sealed container, away from light, moisture, and incompatible substances such as strong oxidizing agents. Store it in a cool, dry, well-ventilated area, preferably in a chemical storage cabinet designed for hazardous chemicals. Clearly label the container and keep it away from sources of ignition and direct sunlight. |
| Shelf Life | 3-Bromo-2-hydroxypyridine should be stored dry, cool, and dark; shelf life is typically 2–3 years under proper conditions. |
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Purity 98%: 3-Bromo-2-hydroxypyridine with purity 98% is used in pharmaceutical intermediate synthesis, where high yield and minimal impurity formation are achieved. Molecular weight 174.99 g/mol: 3-Bromo-2-hydroxypyridine with molecular weight 174.99 g/mol is used in heterocyclic compound production, where precise stoichiometric calculations ensure accurate molecular assembly. Melting point 126-129°C: 3-Bromo-2-hydroxypyridine with melting point 126-129°C is utilized in solid-phase extraction processes, where thermal stability aids efficient separation and purification. Particle size <50 microns: 3-Bromo-2-hydroxypyridine with particle size less than 50 microns is used in fine chemical formulation, where enhanced dissolution rate facilitates homogenous blending. Stability temperature up to 80°C: 3-Bromo-2-hydroxypyridine with stability temperature up to 80°C is used in temperature-controlled synthesis, where maintained structural integrity supports consistent product quality. |
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Working with heterocyclic compounds has always been a central part of my daily lab routine. Out of countless pyridine derivatives, 3-Bromo-2-hydroxypyridine has stood out for its adaptability and reliability. Whether used in pharmaceutical research labs or chemical manufacturing floors, it brings together two highly reactive functional groups — bromine at the third carbon and a hydroxyl at the second — which unlock new directions for building complex molecules. With a formula of C5H4BrNO and a molecular weight just under 175 g/mol, the compound sits in a sweet spot between versatility and manageability for research and scale-up alike.
The particular placement of bromine and hydroxyl groups on the pyridine ring isn’t accidental or trivial. In my own experience, attempts to attach functional groups at other positions often led to a drop in selectivity or reaction yields. The 3-bromo group acts as an excellent leaving group for nucleophilic substitution, while the 2-hydroxyl can participate in hydrogen bonding, making this molecule more than just a simple starting material. Its dual reactivity helps anyone in the lab push past synthetic roadblocks, making it a favorite among chemists looking to design kinase inhibitors, agrochemical intermediates, or advanced organic frameworks.
In the last decade, demand for building blocks like 3-Bromo-2-hydroxypyridine has spiked as drug discovery moves toward more complex, highly functionalized molecules. Medicinal chemistry teams lean on it to quickly assemble new scaffolds for lead optimization. Process chemists appreciate its high reactivity, reducing the number of steps needed in multi-stage syntheses. For those working in agrochemical development, the compound allows the rapid generation of novel herbicides and fungicides, with functional groups that can be tweaked to adjust biological activity and environmental persistence. Its crisp melting point and low solubility in non-polar solvents make it easy to purify, so larger research groups save time at the bench.
Pyridine derivatives crowd the market, but not every option is interchangeable. Regular 2-hydroxypyridine works for straightforward amide couplings, but its lack of halogenation limits further modification. On the other hand, 3-bromopyridine doesn’t offer the secondary functionality many synthetic pathways require. By bringing both groups to the ring, 3-Bromo-2-hydroxypyridine streamlines downstream processing, reduces the need for additional reagents, and cuts back on waste generation. From my own bench work, switching to this compound often means shaving days off project timelines due to cleaner conversions and easier purification steps.
In academic labs and custom synthesis facilities, minor impurities can derail an entire synthesis campaign. Reliable suppliers often provide this product as a white or off-white solid, with purity routinely tested by HPLC, NMR, and GC-MS methods. In my group, we’ve come to trust lots that exceed 98% purity. Trace metal content, moisture, and residual solvents affect crystallization and reproducibility; these are checked batch by batch. I’ve personally chased down product complaints that came back to substandard material, so now I only source from vendors who publish independent analysis reports and happily meet international quality system standards. Careful buying pays off in fewer failed syntheses and quicker troubleshooting.
Anyone who has spent enough time in the lab knows that sensible chemical management goes a long way. Though 3-Bromo-2-hydroxypyridine isn’t the most hazardous pyridine derivative in circulation, gloves and goggles stay on. Fume hoods catch any dust or fumes, and standard spill procedures apply. I’ve seen some labs use it at kilogram scale, so it’s worth noting safe storage procedures and appropriate disposal practices for halogenated organics. Across many countries, regulations require proper waste tracking, and university groups usually partner with third-party service providers for disposal. Keeping an eye on local rules not only keeps the bench safe but shields labs from fines and downtime.
The true value of 3-Bromo-2-hydroxypyridine becomes obvious once the first experiment wraps up. Palladium-catalyzed couplings using this compound open up rapid assembly of biaryl systems, which often play key roles in new antibiotics and anticancer candidates. Direct arylations and Suzuki-Miyaura reactions run cleaner, with higher yields and sharper isolation profiles. Nucleophilic aromatic substitution with this compound moves faster, thanks to the extra electron-withdrawing power of the bromine substituent, a pattern that shows up again and again in my own reaction notebooks.
In any synthetic plan, one eye always fixes on cost and another on performance. Standard pyridine often comes cheaper but loses flexibility and creates more work with protecting groups. Other halogenated pyridines give similar reactivity but lack the specific selectivity possible here, making side products more common. Several large industrial projects I contributed to switched to 3-Bromo-2-hydroxypyridine after wasted batches and complex cleanups using alternatives. Time saved on reaction cycles and product purification adds up to significant cost reductions in multistep runs.
Rapid access to advanced fragments is mission-critical in modern drug discovery. Thousands of research teams lean on 3-Bromo-2-hydroxypyridine as a dependable intermediate, pushing leads from the hit identification phase all the way through preclinical scale-up. Clinical timelines narrow as reliable intermediates reduce bottlenecks. This compound remains a core component in custom routes for kinase inhibitors, anti-inflammatory agents, and central nervous system drugs, with trusted performance backed by years of published syntheses in leading medicinal chemistry journals.
Waste reduction matters as much as product yield in today's labs. Working with a multifunctional intermediate like 3-Bromo-2-hydroxypyridine helps keep reaction steps low and generates fewer byproducts. In my experience, simpler isolation means smaller solvent footprints and a lighter energy bill for the facility. Some suppliers now offer more eco-friendly packaging and support for solvent recycling, which further cuts back on a lab’s environmental impact.
Translating small-batch reactions into production scale doesn’t always go smoothly. Batch consistency, reproducibility, and purity take on new importance with larger quantities. I’ve watched pilot plants run for days with 3-Bromo-2-hydroxypyridine without fouled equipment, thanks to its stable melting point and minimal build-up of tar or side products. Solubility in common polar solvents such as DMSO and DMF lets bulk manufacturers scale up with confidence, tweaking crystallization conditions as needed.
A quick patent search reveals a steady uptick in filings mentioning 3-Bromo-2-hydroxypyridine, reflecting its growing use across markets. Generic manufacturers and established pharma companies alike rely on it for core patent claims involving anticancer compounds, antifungals, and crop protection products. For research teams working to bring new compounds to market, having reliable access to this intermediate means less time spent negotiating IP snarls and more time focused on innovation.
Like many heterocycles, exposure to moisture and light can shorten shelf life. In my group, we keep product sealed tight in amber bottles, stored under low humidity and away from direct sunlight. Packs of molecular sieves go into every new jar opened. Storing large quantities at room temperature works well as long as each batch gets checked periodically by NMR and TLC for signs of degradation.
In project management meetings, delays traceable to missing or compromised intermediates cause more headaches than complicated chemistry. Knowing we can count on fresh stocks of 3-Bromo-2-hydroxypyridine has made a measurable impact on morale and project delivery timelines. Seasoned project leads favor vendors who communicate openly and provide package tracking, batch analysis, and flexible lot sizes. Some of my most productive research sprints trace back to a reliable box of this very compound delivered right on time.
Early syntheses often hit snags due to incomplete conversions or hard-to-separate byproducts. Using analytical tools like in situ NMR and HPLC, my teams continuously monitor each step, especially during substitution and coupling reactions. Dry bases and clean glassware make a difference in yield and reproducibility, especially at higher scales. Monitoring reaction progress prevents wasted material and lets us pivot quickly if an unexpected outcome pops up.
College and graduate students frequently work with pyridine derivatives to learn about heterocyclic chemistry. Lab courses involving 3-Bromo-2-hydroxypyridine teach not just bench skills but also core concepts in reactivity, purification, and spectroscopic analysis. Seeing students puzzle out the differences between substitution on this ring and on simpler aromatic systems drives home just how much chemistry relies on small changes at the molecular level.
Automated workstations and flow chemistry setups now incorporate compounds like 3-Bromo-2-hydroxypyridine with greater ease. Vendor-supplied APIs and digital inventory systems help labs track stock and shelf life, set up reorder triggers, and plan reaction campaigns using real-time data. My group’s experiments with automated reaction monitoring lowered error rates and sped up reaction optimization runs. Adopting digital management for critical intermediates like this has turned into one of our best investments for lab efficiency.
Peer-reviewed studies highlight new routes for functionalizing the pyridine core. 3-Bromo-2-hydroxypyridine continues to serve as a key intermediate for aryl ether formation, introduction of amino substituents, and selective halogen exchange. Recent case studies from leading medicinal chemistry groups detail its role in synthesizing complex natural product analogues, highlighting the product’s role in unlocking routes that simpler pyridines can’t touch.
During global events that disrupted chemical supply chains, teams relying on a single supplier faced tough choices. Those with robust supply networks experienced fewer delays. Today, my own approach involves building relationships with multiple reputable vendors, confirming their audited production standards and reviewing third-party analysis for every batch. Responsive suppliers, clear documentation, and ready technical support make all the difference in preventing hold-ups.
Every research manager juggles budgets. While the sticker price for 3-Bromo-2-hydroxypyridine exceeds some simpler raw materials, its role as a multifunctional intermediate means fewer downstream purchases and process tweaks. Several large-scale projects I’ve managed saved ten to twenty percent on the total cost of goods after making the switch, due to reduced labor, solvent, and purification overhead. Upfront investment in quality pays off quickly.
Green chemistry initiatives now steer development choices. Some labs experiment with more sustainable halogen sources and water-based solvents when using compounds like 3-Bromo-2-hydroxypyridine. Choosing intermediates that enable efficient transformations with fewer reagents supports broader efforts to reduce waste and carbon footprint. Several of my younger colleagues prioritize greener synthesis in their publications, and it’s rewarding to see the industry responding with cleaner processes and packaging strategies.
Modern chemical development pulls in experts from synthetic organic chemistry, analytical chemistry, engineering, and environmental health. Interdisciplinary project teams use compounds like 3-Bromo-2-hydroxypyridine as common ground, sharing best practices, troubleshooting tips, and efficiency benchmarks. Bringing together diverse perspectives results in safer, faster, more innovative workflows, a trend I’ve seen up close on joint industry-academia research consortia.
Few intermediates have earned as much trust and respect at the bench as 3-Bromo-2-hydroxypyridine. Bridging the gap between simplicity and reactivity, it supports meaningful progress in pharmaceutical research, crop science, fine chemical development, and education. Years spent troubleshooting syntheses and reviewing analytical results have left me with a deep appreciation for how a single molecule can accelerate discovery, streamline production, and drive a better future for labs navigating ever-growing scientific challenges. Investing in reliable, well-characterized intermediates gives every research program the foundation it needs to reach the next breakthrough.
