|
HS Code |
737915 |
| Cas Number | 876346-38-0 |
| Chemical Name | 3-Bromo-2-hydroxy-5-methylpyridine |
| Molecular Formula | C6H6BrNO |
| Molecular Weight | 188.02 g/mol |
| Appearance | White to off-white powder |
| Melting Point | 93-98°C |
| Solubility | Slightly soluble in water, soluble in organic solvents |
| Purity | Typically ≥98% |
| Storage Condition | Cool, dry place; tightly closed container |
| Synonyms | 3-Bromo-5-methyl-2-pyridinol |
| Smiles | Cc1cc(Br)nc(O)c1 |
| Inchi | InChI=1S/C6H6BrNO/c1-4-2-5(7)8-6(9)3-4/h2-3,9H,1H3 |
As an accredited 3-Bromo-2-hydroxy-5-methylpyridine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | The 10g of 3-Bromo-2-hydroxy-5-methylpyridine is sealed in an amber glass bottle with a tamper-evident screw cap. |
| Container Loading (20′ FCL) | Container Loading (20′ FCL) for 3-Bromo-2-hydroxy-5-methylpyridine: Typically 11-14 MT, packed in 25 kg fiber drums, securely palletized. |
| Shipping | Shipping of **3-Bromo-2-hydroxy-5-methylpyridine** is conducted in compliance with international chemical transport regulations. The compound is packaged in tightly sealed containers, protected from moisture and light. Proper labeling and documentation are included, with precautions for handling hazardous materials. Expedite delivery options and tracking are available to ensure safe and timely arrival. |
| Storage | 3-Bromo-2-hydroxy-5-methylpyridine should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area, away from sources of heat, ignition, and direct sunlight. Keep it separated from incompatible substances such as strong oxidizers and acids. Store at room temperature and avoid moisture exposure. Clearly label the container and restrict access to trained personnel only. |
| Shelf Life | 3-Bromo-2-hydroxy-5-methylpyridine typically has a shelf life of 2 years when stored in a cool, dry, and dark place. |
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Purity 98%: 3-Bromo-2-hydroxy-5-methylpyridine with purity 98% is used in pharmaceutical intermediate synthesis, where enhanced yield and reduced impurities are achieved. Melting Point 128°C: 3-Bromo-2-hydroxy-5-methylpyridine with melting point 128°C is applied in solid dosage form manufacturing, where thermal process stability is maintained. Molecular Weight 188.03 g/mol: 3-Bromo-2-hydroxy-5-methylpyridine at molecular weight 188.03 g/mol is used in medicinal chemistry research, where precise compound profiling enables targeted drug development. Particle Size <50 µm: 3-Bromo-2-hydroxy-5-methylpyridine with particle size less than 50 µm is used in nanoparticle formulation, where improved suspension and dispersion are required. Water Content <0.5%: 3-Bromo-2-hydroxy-5-methylpyridine with water content below 0.5% is used in moisture-sensitive synthesis, where product degradation is minimized. Stability Temperature up to 150°C: 3-Bromo-2-hydroxy-5-methylpyridine with stability up to 150°C is used in high-temperature organic reactions, where compound integrity is preserved. UV Absorbance (λmax 270 nm): 3-Bromo-2-hydroxy-5-methylpyridine with UV absorbance at 270 nm is used in analytical method development, where accurate quantification by spectrophotometry is possible. Assay ≥99%: 3-Bromo-2-hydroxy-5-methylpyridine with assay of at least 99% is utilized in reference standard preparation, where analytical reliability is ensured. |
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The road to innovation in chemistry often begins with a single, well-characterized molecule. Among the building blocks that have shaped progress in pharmaceuticals and advanced materials, 3-Bromo-2-hydroxy-5-methylpyridine draws steady attention. In recent years, I’ve seen synthetic labs and process chemists turn to this compound when searching for a versatile intermediate that brings both selectivity and reactivity. Its distinctive ring system—pyridine with bromo, hydroxy, and methyl substitutions—opens doors that unsubstituted pyridines leave shut.
My own introduction to this molecule came during a project focused on drug discovery. We searched for novel scaffolds and encountered bottlenecks with less reactive or overly symmetrical pyridines. 3-Bromo-2-hydroxy-5-methylpyridine broke that impasse. Its bromo group sits ready for Suzuki and Buchwald-Hartwig couplings, handing medicinal chemists the freedom to explore aromatic diversity. The hydroxyl next door encourages downstream modifications like O-alkylation or the creation of prodrug esters, crucial when tailoring pharmacokinetic profiles.
For anyone involved in medicinal chemistry, predictability and control matter. I’ve seen projects falter because a molecule refused to participate in select cross-coupling reactions or delivered too many byproducts. Here’s where this pyridine skips past many stubborn bottlenecks. Its bromine leaves selectively, without the complications that often arrive with iodo or chloro analogues. The methyl group locks in regioselectivity, reducing the chance of side reactions. Instead of endless attempts at purification, most reactions using this intermediate run clean and deliver hefty yields.
My experience also shows that this compound holds advantages over analogous chemicals like 2-bromo-5-methylpyridine or 3-bromo-2-hydroxypyridine. The extra methyl at the five position nudges reactivity in subtle ways. It stabilizes certain intermediates but doesn’t crowd out the ortho-hydroxy group. The result is enough electronic push to tune reactivity without blocking access for enzymes or catalysts. Measured by the time saved in purification and the certainty in synthetic outcomes, those differences become concrete—all the more so when scaling to kilo quantities.
Chemists enjoy getting down to the details, but too often, specifications turn into a tangle of purity percentages and analytical abbreviations. I’ve worked with dozens of batches, and the practical truth is clear: consistency makes or breaks a synthesis. Look for a crystalline powder, colorless to pale beige, maintaining purity above 98%. Typical protocols test for melting points within a tightly defined range, because shifts in this property usually highlight impurities. Closed containers keep the air and moisture out, so oxidation or hydrolysis won’t creep in over time. I don’t recall any successful run when storage slipped or when someone used degraded material—those missteps never pay off down the line.
A seasoned chemist recognizes the difference that comes from minor substitutions on a core framework. In this molecule, the trio of substituents transform a basic heterocycle into a robust synthetic intermediate. You won’t see the same breadth of cross-coupling options with plain methylpyridines, nor the same selectivity with non-hydroxylated bromo analogues. When working on fluorescent probes or catalysts, small structural choices can push a product from mediocrity to top performer. I’ve witnessed this during the development of kinase inhibitors and fluorescent chelators, where the hydroxy group unlocks coordination with metal ions while the bromo handles arylation.
Beyond the lab, there’s growing demand for building blocks that streamline synthesis without introducing regulatory headaches. Certain halogenated pyridines gain unwanted attention due to environmental persistence. From everything I’ve read and tested, the substitution pattern here tends to minimize the risks associated with some heavier halogen atoms or entirely unsubstituted compounds. As the field moves toward greener synthesis, such features help companies address regulatory and sustainability demands at the planning stage—rather than scrambling to fix issues after a product launch.
People often assume small building blocks only matter in obscure research projects. My time in the pharmaceutical and fine chemical sectors tells a different story. Imagine the synthesis of an advanced pharmaceutical intermediate: it’s measured in hours of troubleshooting and grams of material. A single flawed building block adds months to the project. With 3-Bromo-2-hydroxy-5-methylpyridine, teams compress timelines, drive down costs, and curb waste. This efficiency isn’t abstract—chemists see the difference in output and quality.
I’ve watched the switch to this compound tip the balance for custom manufacturing agreements, where both price and reproducibility spark negotiations. Saving even five percent of solvent or energy during a cross-coupling delivers real dividends at scale. In university labs, students value its reliability for thesis projects, knowing they can focus on reaction optimization instead of troubleshooting starting materials. Researchers in agrochemicals have started using it for fungicide lead optimization, and it’s found a place in the development of photochemical materials, serving as a backbone that tolerates further derivatization.
A molecule’s power comes from context, and I’ve seen this pyridine outperform its neighbors in several real applications. Compare it to simple bromo-pyridines: you’ll find sharper selectivity with fewer ortho or meta isomers muddying your product. Against counterparts lacking a methyl or hydroxy group, this variant often produces better yields in O-acylation and arylation, and it resists overreaction in conditions that push less stable analogues. In combinatorial chemistry, this stability keeps libraries clean and diversified—an underrated edge when racing to meet a drug target.
Other compounds frequently fall short during purification, layering extra work onto already stretched research teams. The methyl group here prevents oxidation and unwanted side-chain reactions, a concern with unsubstituted or polyhalogenated pyridines. From process development through final QC, this reliability shines: few side-products, little chromatographic clean-up, and shelf stability even in unforgiving warehouse environments.
People trust facts over sales pitches, so let’s get specific. Literature documents robust protocols drawing on this compound, especially for C-N bond formation and Suzuki couplings. Reactions often proceed cleanly at moderate temperatures, usually between 60-100°C with standard palladium catalysts. Isolated yields consistently clear the 85% mark in published examples. In my own runs, I rarely see side reactions when sticking to validated solvent systems and using fresh, high-purity material.
Mass spec, NMR, and IR spectra match expectations for a compound of this structure, which offers peace of mind during reaction monitoring. There’s little evidence for rapid decomposition under standard storage, and well-packed batches hold up for months. Colleagues working with related pyridines have reported frustrating hydrolysis and color changes; these problems almost vanish with this specific combination of methyl, hydroxy, and bromo.
The difference between a good research chemical and an excellent one often comes down to what happens over weeks rather than a single reaction. I’ve seen projects stay on track because researchers could rely on a steady supply chain and a consistent physical product. This reliability allows scale-up from milligrams in a trial to kilograms for pilot batches. Most intermediates designed for early discovery crumble or react unpredictably under the harsher conditions of production chemistry, yet this pyridine keeps its composure. Its crystalline powder resists moisture better than many similar compounds, simplifying long-term storage.
Students and professionals both report satisfaction with its solubility profile: adequate in polar aprotic solvents and tolerable in water-miscible organics. Cleanup proves straightforward, with minimal risk of hazardous byproducts and reduced need for advanced analytical troubleshooting during workup. The high purity seen in commercially available samples pays off directly in easier downstream reactions, higher reproducibility, and fewer costly surprises.
Once you step outside the research lab, the role of specialty pyridines expands rapidly. Diversified chemical manufacturers now expect intermediates to serve in multiple downstream processes: pharmaceutical APIs, dye precursors, agrochemical leads, and specialty polymers. The dual presence of hydroxy and bromo groups provides more than one synthetic handle, cutting the number of separate building blocks required in a process. I've watched development timelines shrink as a result, making it possible to move from concept to marketable compound with fewer procurement headaches.
In addition, the structure’s manageability simplifies compliance with quality and safety audits. Many companies report streamlined risk assessments, reduced special handling needs, and easier waste management protocols compared to heavier halogenated heterocycles or unstable intermediates. All of these advantages trickle down to the bottom line, strengthening margins in almost every chemical sector touched by pyridine chemistry.
Increasing public interest in the origins and environmental fate of laboratory chemicals drives change within the field. There’s mounting pressure from regulatory bodies and customers alike to ensure intermediates reflect sound environmental stewardship. 3-Bromo-2-hydroxy-5-methylpyridine fits into this new landscape more smoothly than many alternatives. Its production often uses mild conditions and avoids reagents flagged for occupational hazards. During use and disposal, its reduced volatility and moderate reactivity limit the scope of workplace exposure.
Conversations with sustainability officers and process chemists reinforce the point: a well-designed intermediate routes synthesis clear of many environmental or safety dead ends. This efficiency translates to lower waste, fewer hazardous side-streams, and improved operator safety. For the growing crop of green chemistry programs springing up in industry and academia, this profile keeps them moving steadily forward instead of battling legacy chemical problems.
No project thrives in chaos. With every batch, I see teams value clear, consistent feedback from suppliers. Trusted providers conduct thorough analyses and issue transparent certificates of analysis, a practice born of decades of lessons learned in the field. When testing this pyridine, reputable suppliers monitor for trace metals and organic contaminants—the kinds that derail complex syntheses or set off alarms during regulatory reviews.
An overlooked benefit, but a real one, is the opportunity for rapid troubleshooting if a reaction misbehaves. The wealth of reference spectra and published protocols surrounding 3-Bromo-2-hydroxy-5-methylpyridine allows chemists to skip weeks of method development and quickly identify any outliers. This minimizes the risk of project setbacks and empowers teams to act with confidence—characteristics embraced by every successful research group I’ve observed.
The pressure to innovate drives selection in every catalog, grant application, and synthetic plan. At the earliest project meetings, chemists now favor building blocks proven reliable—not just in the literature, but in the daily grind of real work. 3-Bromo-2-hydroxy-5-methylpyridine meets this demand. Teams leverage its dual functional groups to leapfrog traditional bottlenecks, opening new areas for molecular diversification. The compound empowers everything from quick library synthesis for kinase binders to patient, iterative optimizations in advanced material science.
Smart purchasing teams also take note of its long shelf life and readiness for scale-up, which cuts hidden costs and reduces supply chain risk. Companies have shifted to a proactive stance, stocking up with confidence and keeping projects moving during unexpected delays or market swings. This agility, in turn, supports research freedom and commercial nimbleness—a difference felt across the entire value chain.
No chemical comes without its share of challenges. As adoption widens, some users bump into issues of batch variability and occasional bottlenecks in sourcing precursor materials. My discussions with procurement managers reveal that competitive pressures sometimes tempt suppliers to cut corners on quality control or material origin tracing. These shortfalls impact downstream users in costly ways if left unaddressed. A strong culture of accountability, including supplier audits and third-party validation, provides real safeguards and should become routine for organizations relying on this or similar compounds.
Another area ripe for progress involves greener synthesis routes. Although current manufacturing methods already minimize some hazards, advances in catalysis and waste reduction hold promise for even leaner, cleaner processes. Research groups working in biocatalysis and flow chemistry bring a fresh perspective, potentially paving the way for more sustainable sourcing.
The story of this molecule mirrors many seen across scientific discovery—a search for better tools leading through trial, error, and refinement to compounds that shape what’s possible in the lab and in the market. Moving forward, there’s room for industry to share best practices, develop cleaner production routes, and reinforce quality standards. Research teams can also push the boundaries by exploring fresh applications, moving past established chemistries and finding unexpected uses for this versatile pyridine.
Investing in relationships throughout the supply chain—rather than choosing solely based on price—delivers the most reliable outcomes. This includes open communication, collaborative troubleshooting, and support for responsible sourcing. By maintaining these values, those working with specialty chemicals will not only complete projects faster and with higher confidence but also contribute to a safer, smarter, and more sustainable field.
Looking back at my experience and observing industry trends, 3-Bromo-2-hydroxy-5-methylpyridine earns its place on the bench as much as in bulk synthesis. Its unique structure, reliable reactivity, and clean performance anchor its popularity among chemists seeking both reliability and innovation. While the field will keep evolving, chemicals offering a blend of practical advantages, high purity, and meaningful routes toward sustainability will stay front and center. In my view, this pyridine continues to prove its value—one reaction, one project, one innovative step at a time.
