|
HS Code |
181498 |
| Chemical Name | 3-Amino-2-chloro-4-methylpyridine |
| Molecular Formula | C6H7ClN2 |
| Molecular Weight | 142.59 g/mol |
| Cas Number | 86483-13-0 |
| Appearance | Pale yellow to yellow solid |
| Melting Point | 85-89°C |
| Boiling Point | No data available |
| Purity | Typically ≥98% |
| Solubility | Soluble in organic solvents such as DMSO and methanol |
| Storage Conditions | Store in a cool, dry place, tightly closed |
| Smiles | CC1=CC(=C(N)N=C1)Cl |
| Synonyms | 2-Chloro-4-methyl-3-aminopyridine |
As an accredited 3-Amino-2-chloro-4-methyl pyridine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | The 100g 3-Amino-2-chloro-4-methyl pyridine comes in a sealed amber glass bottle with a tamper-evident screw cap. |
| Container Loading (20′ FCL) | 20′ FCL loads 13.5 MT of 3-Amino-2-chloro-4-methyl pyridine, packed in 225 kg HDPE drums, securely palletized. |
| Shipping | 3-Amino-2-chloro-4-methyl pyridine is shipped in tightly sealed containers compliant with chemical safety standards. It should be protected from light, moisture, and sources of ignition. During transit, proper labeling and documentation are required, and handling must follow relevant regulations for potentially hazardous organic compounds to ensure safety and prevent contamination. |
| Storage | **3-Amino-2-chloro-4-methyl pyridine** should be stored in a tightly closed container, in a cool, dry, and well-ventilated area away from incompatible substances such as strong oxidizers and acids. Protect the chemical from light and moisture. Store at room temperature. Always follow standard laboratory safety procedures and ensure proper labeling and safety equipment are in place. |
| Shelf Life | Shelf life of 3-Amino-2-chloro-4-methyl pyridine is typically 2 years when stored in a cool, dry, and sealed container. |
|
Purity 98%: 3-Amino-2-chloro-4-methyl pyridine with purity 98% is used in pharmaceutical intermediate synthesis, where it ensures high yield and minimal impurity levels. Melting point 99°C: 3-Amino-2-chloro-4-methyl pyridine with a melting point of 99°C is used in agrochemical production, where it provides consistent processability under controlled thermal conditions. Low moisture content (<0.5%): 3-Amino-2-chloro-4-methyl pyridine with low moisture content is used in API manufacturing, where it enhances compound stability and shelf-life. Stability temperature up to 120°C: 3-Amino-2-chloro-4-methyl pyridine stable up to 120°C is used in catalyst preparation, where it maintains molecular integrity during high-temperature processing. Particle size 50–100 μm: 3-Amino-2-chloro-4-methyl pyridine with a particle size of 50–100 μm is used in fine chemical blending, where it enables uniform dispersion and reactivity. Assay 99%: 3-Amino-2-chloro-4-methyl pyridine with assay 99% is used in heterocyclic compound synthesis, where it delivers reliable purity for reproducible chemical reactions. Residue on ignition <0.1%: 3-Amino-2-chloro-4-methyl pyridine with residue on ignition below 0.1% is used in electronic chemical formulation, where it prevents unwanted ionic contamination. Chlorine content 16.2%: 3-Amino-2-chloro-4-methyl pyridine with a chlorine content of 16.2% is used in specialty dye precursor production, where it achieves targeted chromophore functionality. Solubility in methanol: 3-Amino-2-chloro-4-methyl pyridine soluble in methanol is used in analytical reference standard preparation, where it allows for efficient solution making and accurate quantification. Reactivity at pH 7: 3-Amino-2-chloro-4-methyl pyridine with stable reactivity at pH 7 is used in biochemical assay development, where it ensures predictable interaction profiles. |
Competitive 3-Amino-2-chloro-4-methyl pyridine prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please contact us at +8615371019725 or mail to sales7@boxa-chem.com.
We will respond to you as soon as possible.
Tel: +8615371019725
Email: sales7@boxa-chem.com
Flexible payment, competitive price, premium service - Inquire now!
Chemistry labs often rely on specific starting materials, and among pyridine derivatives, 3-Amino-2-chloro-4-methyl pyridine stands out for both its unique structure and reliability. Its chemical backbone, carrying an amino, a chloro, and a methyl group around the pyridine ring, gives chemists a real sense of control over downstream reaction plans. I’ve seen researchers favor this compound in discovery-phase projects, drawn to its ability to connect with both electrophilic and nucleophilic partners. The individual groups around the ring help steer selectivity during transformations—something that means less trial, less error, and ultimately, less wasted time.
Handling chemicals in the lab can be a sticking point. So many substances either clump up in air or end up producing dust that escapes into the workspace. The typical crystalline solid form of 3-Amino-2-chloro-4-methyl pyridine gives researchers an everyday advantage: it’s easy to weigh out, pour, and dissolve. Unlike some sticky or hygroscopic materials that can pull in moisture and degrade before a reaction even starts, this compound remains manageable on the bench. For anyone who’s had to redo experiments due to sketchy material, that reliability matters.
Plenty of other pyridines line the shelves in the chemist’s storeroom, but few come with this specific arrangement of functional groups. The chlorine atom at the 2-position keeps the nitrogen from unexpected side reactions, and that means you can better target substitution at other positions. The amino group opens up all kinds of cross-coupling, amide bond formation, and even direct condensation strategies without lengthy protection-deprotection cycles. Add to this the methyl group at the 4-position, and the electronic properties of the whole molecule shift in ways that can be fine-tuned for specific needs. Where other pyridine derivatives require extra steps to introduce these groups, this one brings them together from the start.
In my view, the real mark of a valuable chemical starts with stories from the lab. 3-Amino-2-chloro-4-methyl pyridine often shows up in medicinal chemistry programs, because its core can be tweaked to reach a wide range of biological targets. Some researchers use it to create libraries for kinase inhibitors, given the importance of the aromatic ring in binding at ATP pockets. In agrochemicals, modification of this scaffold can lead to herbicides or fungicides that manage resistance while staying clear of older, less selective molecules. Polymer and dye chemists have picked up this compound for similar reasons: structural flexibility meets chemical sturdiness.
Every workflow has a bottleneck. In synthetic chemistry, that’s often the number of steps needed to reach your target molecule. Having a compound like 3-Amino-2-chloro-4-methyl pyridine means you start with a structure that’s already been decorated in useful ways. You avoid the need for multiple separate reactions to add an amino group here, a chloro group there, and a methyl group somewhere else. Any chemist who’s done this the hard way knows how troublesome selective functionalization can get. By starting with all groups in place, projects run faster, and resources stretch further—a key point for both academic and industrial innovation.
Synthetic work only runs smoothly when the starting materials behave as expected. 3-Amino-2-chloro-4-methyl pyridine regularly appears at high levels of purity, with major suppliers ensuring batch-to-batch consistency. This matters not just for reproducibility but also for the efficiency of scale-up work. I’ve seen what happens when reactions get derailed by unknown byproducts from impure starting material—troubleshooting those problems can halt a month’s progress. Reliable material means more time spent on creative problem-solving and less time dealing with the unexpected.
With increasing attention on safer chemical processes, it’s worth noting that 3-Amino-2-chloro-4-methyl pyridine doesn’t come with the baggage of heavy metal contaminants or toxic solvents often needed for its synthesis or use. Researchers aware of green chemistry principles see an advantage here, as modern preparations minimize hazardous waste. Laboratories benefit too: less time spent on complex waste disposal and fewer regulatory headaches downstream. Focus stays on research goals, not compliance paperwork.
Making smart choices in experimental design means working from robust, trustworthy data. 3-Amino-2-chloro-4-methyl pyridine comes with well-documented NMR, MS, and IR spectra, along with physical property data like melting point and solubility in common organic solvents. This has allowed teams to predict reactivity and plan downstream transformations with confidence. Documentation from multiple sources builds confidence, especially in highly regulated or publication-driven environments. Peer-reviewed references and supplier-provided spectra give researchers the facts they need, streamlining both project planning and troubleshooting.
One thing that stands out about this compound is its compatibility with different reaction types. The pyridine ring tolerates a good range of bases, acids, and metal catalysts. I’ve worked on parallel synthesis campaigns where everything needs to run in tubes or mini-reactors before picking the best result, and this kind of chemical resilience saves lots of runs from unintended side reactions. Whether you’re aiming for Suzuki-Miyaura, Buchwald-Hartwig, or peptide coupling chemistry, the substance offers a solid platform to build on.
While it’s easy to sing the praises of any high-demand building block, challenges do come up. Handling and storage practices must stay sharp, especially for researchers looking to keep material stable over longer periods. In hot or humid climates, even tough-looking powders can absorb traces of water, leading to clumping or slow decomposition. Tightly sealed, well-labeled containers, kept away from excess moisture and heat, help maintain quality for larger-scale synthesis campaigns.
Looking at suppliers and alternatives, 3-Amino-2-chloro-4-methyl pyridine delivers value through its combination of ready-to-use functional groups and broad methodological compatibility. Pyridine derivatives without such a mix often mean extra time and expense to customize basic structures for each new series. Over the years, researchers have shifted away from more generic scaffolds toward tailored starting points that fit both microwave and conventional synthesis workflows. This product rides that trend, giving labs an approachable entry point for fast-paced programs, without sacrificing the versatility demanded by today’s chemists.
Research organizations increasingly expect thorough documentation, even for internal discovery work. 3-Amino-2-chloro-4-methyl pyridine arrives with verified certificates of analysis, validated by both HPLC and NMR. This transparency makes it easier to meet institutional requirements for audit trails, and opens doors for future commercialization. With regulatory frameworks tightening around data integrity—especially in pharma and fine chemicals—trusted documentation weighs as heavily as technical performance.
New products and treatments get their start from reliable small molecules. 3-Amino-2-chloro-4-methyl pyridine plays an outsized role for a compound of its size, providing a launchpad for new chemistry and biology connections. In collaborations between academia and industry, I’ve seen it give teams a reliable, well-defined starting point for SAR studies, high-throughput screening, and even the early stages of process development. With increasing crossover between medicinal chemistry, synthetic methodology, and chemical engineering, the need for substances that bridge fundamental reactivity and scalability only grows.
Conversations with colleagues always surface real-life advantages and hiccups. Many report shortening lead optimization timelines due to the functional group arrangement, skipping at least two or three steps compared to building their own scaffold from basic pyridines. Some raise questions about large-scale sourcing, pointing out that consistent supply at the tens-to-hundreds of grams level remains critical for projects with tight turnaround times. Others point to the improving availability as more suppliers recognize its importance in fast-moving discovery work.
As drug targets become more complex and the pressure to identify new materials increases, starting materials like 3-Amino-2-chloro-4-methyl pyridine prove their worth. The trend toward late-stage functionalization and the use of automation in lead discovery both lean on substrates that can flex in response to evolving research priorities. New synthetic methodologies—such as photoredox catalysis and flow chemistry—are opening up even more paths for this molecule, highlighting its resilience and adaptability as experimental needs shift.
Sustainability goals in both academic and industrial labs are putting pressure on the chemical marketplace. For pyridine derivatives, routes that use fewer hazardous reagents and generate less waste play a big part in longer-term purchasing decisions. The straightforward, multistep-free use of 3-Amino-2-chloro-4-methyl pyridine lessens the need for extensive purification or side-product separation, which in turn cuts the solvent and energy footprint of multi-gram and multi-kilogram runs. That’s practical progress for teams committed to greener synthesis.
Synthetic innovation doesn’t stop at proof-of-concept. To reach large-scale demonstration or commercial use, every small advantage in starting material design ripples outward. I remember working on one process scale-up in which changing the core scaffold shaved two purification steps and reduced the amount of palladium required, all because the starting amino-chloro-methyl combination provided a more reliable entry point. Those changes cut cycle times and costs, making the chemistry more attractive for license partners and funders.
Hands-on experience matters in chemistry. Training students on reliable, functionally rich molecules helps bridge textbook concepts and real-world troubleshooting. 3-Amino-2-chloro-4-methyl pyridine, with its clear NMR and straightforward handling, features in many college and grad-school experiments where selectivity, reactivity, and purification can be taught together, using a single, well-behaved compound. That practical exposure lowers the barrier for new researchers and gives experienced staff a teaching tool with few surprises.
Recent research directions in the pharmaceutical and materials sectors often hinge on rapid generation of molecular diversity. This compound, ready-made for cross-coupling and derivatization, enables teams to push the limits of what structure-activity relationships can explore, without exhausting the research budget or timeline. Patent activity and published literature make clear just how central this scaffold has become, especially as more research programs pivot to agile, structure-guided design.
Moving ideas out of the lab and into the pilot plant requires robust, scalable chemistry. Teams aiming to manufacture fine chemicals or build block copolymers turn to building blocks that maintain their character under pressure, heat, and long process times. With its predictable reactivity and chemical strength, 3-Amino-2-chloro-4-methyl pyridine streamlines the move from milligrams to kilograms—and that scalability often means fewer surprises come QA time, as consistent behavior matches what smaller-scale experiments predicted.
Recent years have made supply chain agility a key focus. Researchers learned the hard way that obscure intermediates or poorly defined chemicals can pinch projects without warning. Expanding manufacturing and clear, third-party-verified materials sourcing for 3-Amino-2-chloro-4-methyl pyridine marks an important trend. As demand grows in both research and industry, sources in multiple regions help guarantee accessibility, reduce shipping lead times, and buffer teams from market volatility.
From my own work, I’ve come to see that the most trusted chemicals do their job quietly in the background, supporting a wide field of possibility. 3-Amino-2-chloro-4-methyl pyridine fits that model well. As new reaction methodologies hit the literature—often requiring specific handles for optimal performance—this compound keeps meeting chemists where they are. It remains useful both for old-school flask work and high-throughput robotics, adapting as new technologies emerge.
Partnerships depend on shared tools and common ground. This molecule provides a literal common ground for cross-disciplinary work, whether in public-private partnerships or international teams. Standardizing on compounds with accessible documentation and known reactivity enables transparent troubleshooting and meaningful data comparison. That’s a quiet, powerful way to help ambitious projects steer clear of basic mistakes and move toward impactful results.
Every research team feels pressure to deliver results, whether the goal is a drug candidate, a new polymer, or a color-fast industrial dye. Building that outcome on reliable substrates can mean the difference between dead ends and clear, productive paths forward. With its balance of chemical opportunity and practical performability, 3-Amino-2-chloro-4-methyl pyridine has earned its reputation as a cornerstone in the chemical research landscape—a status built on experience, not marketing.
Relying on trustworthy building blocks lets researchers focus attention and creativity on more important challenges. That’s how 3-Amino-2-chloro-4-methyl pyridine helps push projects beyond the basics—by acting as a foundation, not a hurdle. As workflows become more connected, data-driven, and automated, the value of robust, functionally diverse compounds only stands to increase. Solutions to today’s most urgent scientific questions may start with a small bottle on a laboratory shelf, waiting for the right pair of hands and a little bit of insight.
