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HS Code |
298747 |
| Productname | 3-Amino-2,5-dichloropyridine |
| Casnumber | 15132-23-9 |
| Molecularformula | C5H4Cl2N2 |
| Molecularweight | 163.01 |
| Appearance | Light yellow to beige crystalline powder |
| Meltingpoint | 94-98°C |
| Purity | Typically ≥98% |
| Solubility | Slightly soluble in water, soluble in organic solvents (e.g., DMSO, ethanol) |
| Density | Approximately 1.48 g/cm³ |
| Smiles | C1=CC(=NC(=C1Cl)N)Cl |
| Inchi | InChI=1S/C5H4Cl2N2/c6-3-1-2-4(8)9-5(3)7/h1-2H,(H2,8,9) |
As an accredited 3-Amino-2,5-dichloropyridine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | The chemical is packaged in a 100-gram amber glass bottle with a secure screw cap and clearly labeled for laboratory use. |
| Container Loading (20′ FCL) | **3-Amino-2,5-dichloropyridine**: Typically loaded in 25 kg fiber drums or bags, 20′ FCL holds about 8–10 metric tons securely. |
| Shipping | 3-Amino-2,5-dichloropyridine is shipped in tightly sealed containers to prevent moisture and contamination. It is typically transported as a solid, under ambient or controlled temperatures. Appropriate hazard labeling and documentation are provided, as it may be classified as a hazardous material. Personnel handling shipping should follow chemical safety guidelines and regulations. |
| Storage | 3-Amino-2,5-dichloropyridine should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area, away from sources of ignition and incompatible substances such as strong oxidizers. Avoid exposure to moisture and direct sunlight. Use chemical-resistant packaging and appropriate labeling. Handle with proper personal protective equipment to prevent contact with skin and eyes. |
| Shelf Life | 3-Amino-2,5-dichloropyridine is stable under recommended storage conditions; shelf life is typically 2-3 years in a cool, dry place. |
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Purity 98%: 3-Amino-2,5-dichloropyridine with purity 98% is used in pharmaceutical intermediate synthesis, where it ensures high product yield and minimal impurities. Melting Point 80°C: 3-Amino-2,5-dichloropyridine with a melting point of 80°C is utilized in organic synthesis reactions, where it enables controlled processing conditions. Molecular Weight 163.01 g/mol: 3-Amino-2,5-dichloropyridine at molecular weight 163.01 g/mol is applied in agrochemical research, where it delivers precise formulation calculations. Stability Temperature 120°C: 3-Amino-2,5-dichloropyridine with stability up to 120°C is used in high-temperature reactions, where it maintains structural integrity and performance. Particle Size <50 μm: 3-Amino-2,5-dichloropyridine with particle size less than 50 μm is incorporated in fine chemical manufacturing, where it provides improved reactivity and dispersion. Moisture Content <0.5%: 3-Amino-2,5-dichloropyridine with moisture content below 0.5% is used in catalyst production, where it enhances stability and prolongs shelf-life. |
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Stepping into any well-equipped laboratory, you notice a new generation of chemicals shaping research and production. The compound 3-Amino-2,5-dichloropyridine stands out for more than its molecular structure. As someone who’s spent years working with organic syntheses, I know how important it can be to choose the right chemical building block — not just for yield, but for reliability and safety. Finding an intermediate that fits the job without causing added headaches makes a difference in the long run.
Model numbers and catalog listings sometimes blur together, especially when names grow long and complex. In reality, the defining qualities of 3-Amino-2,5-dichloropyridine aren’t just found in its structure, but in the way it responds to a chemist’s intent. Laboratories reach for this compound to start or progress syntheses involving more intricate frameworks, particularly where precision and reactivity are crucial. This pyridine derivative, with its dichloro groups on the ring and an amine in a key position, offers a powerful handle for further modification.
Sifting through bottles on crowded shelves, you spot a white to light tan powder in a tightly sealed jar. That’s the typical appearance of 3-Amino-2,5-dichloropyridine. Chemists value its high purity — often north of 98% by HPLC or GC — because impurities at this stage can derail downstream steps or affect sensitive catalyst systems. The melting point usually lands around 120–124°C, which helps confirm identity and aids planning during process scale-up.
Practical details about handling sometimes get overlooked. In my experience, solid forms like this bring a welcome sense of consistency. You don’t have to worry about volatile emissions or unpredictable mixing. Storage commonly involves cool, dry conditions away from direct sunlight, which helps preserve the compound’s integrity. Stability checks confirm that this molecule maintains its quality for months under careful conditions, so early purchases won’t go to waste.
Chemistry can seem abstract from the outside. But to anyone who’s built up pharmacophores or tuned agrochemical ingredients, the subtle differences between similar molecules matter immensely. The dichloro configuration brings balance to the ring, serving as more than mere decoration. These chlorine atoms shift electron density and let the molecule interact with electrophiles or nucleophiles in versatile ways. The amino group, meanwhile, opens doors to acylation, alkylation, or further substitution — making this compound a springboard for inventive synthesis.
Working through multi-step preparations, I’ve found that having this molecule on the shelf gives freedom and peace of mind. Whether scaling up for pilot production or customizing research quantities, you can depend on its reactivity. Researchers aiming for novel heterocycles or preparing advanced intermediates for drug development frequently turn here because it saves time and cuts the risk of late-stage synthesis surprises. There’s no need to cobble together more complicated starting materials when this amine-chlorinated pyridine core does the job with fewer byproducts.
In any catalog, lots of pyridine derivatives jostle for attention. What makes 3-Amino-2,5-dichloropyridine the go-to for experienced chemists isn’t just availability. Its regiochemistry — the exact placement of those chlorine and amino groups — matters. Close cousins like 3-amino-4-chloropyridine or 2,6-dichloropyridine react differently, leading to less control in directed synthesis. Choosing the right substitution means the difference between smooth, high-yielding conversion and weeks hunting down unwanted byproducts.
Over the years, I’ve watched production teams gravitate toward this specific dichlorinated aminopyridine for route scouting and patent-clear syntheses. Compounds with different halogen patterns might show unpredictable reactivity or fail to deliver the required selectivity for downstream coupling reactions. With 3-Amino-2,5-dichloropyridine, there’s a sweet spot between reactivity and stability, which cuts frustration and waste.
Commercial versions also tend to hold up better through cross-country shipping than more fragile analogs. You can receive delivery and get right to work, rather than waiting weeks for a replacement due to shipping mishaps or decomposition. This reliability keeps projects on schedule and helps teams hit their deliverables.
In pharmaceutical research, reliability isn’t a luxury. Over the past decade, heterocycles like this have become linchpins in countless discovery programs. The transition metals and reagents used in today’s methods can be fussy — one stray impurity, and the whole batch might tank. 3-Amino-2,5-dichloropyridine stands out because its consistent quality ensures each experiment and upscale runs in a reproducible, manageable way. Scientists exploring kinase inhibitors, anti-infectives, and CNS-active compounds reach for it when they want more control over substitution at the pyridine core.
Looking beyond pharma, this compound pops up in crop science and specialty materials, where designers want a balance of function and synthetic accessibility. The electronic effects of the dichloro substituents allow fine-tuning of downstream physical properties. In my own work, switching to this intermediate cut time off custom heterocycle synthesis and reduced the failure rates of key steps.
Agrochemical innovators draw on 3-Amino-2,5-dichloropyridine’s scaffold to generate new pesticide backbones that degrade as planned in the environment. The electron-withdrawing effect from its chlorines means intermediates can be tailored for both efficacy and eventual breakdown, supporting regulatory requirements. A handful of specialty polymer and pigment research groups also use these functional handles for applications where thermal and photochemical stability are important.
Every synthetic chemist knows the sinking feeling when an order arrives and the powder isn’t what was expected. Supply chain hiccups have affected chemical sourcing worldwide. With 3-Amino-2,5-dichloropyridine, buyers now see stronger documentation and batch-to-batch lot control from reputable partners. Analytical support, including readily available NMR, HPLC, and mass spectrometry data, reduces the need for time-consuming retesting. Years partnering with trusted sources have taught me the value of communication — a transparent supplier relationship means hiccups get resolved with minimal pain.
Quality control doesn’t stop at the metric of purity. Trace metals, inorganic contamination, and polymorph content all play into the puzzle, especially for those scaling up their operations. Modern providers invest in upgraded facilities to minimize cross-contamination, from segregated manufacturing lines to enhanced filtration. I’ve spent weekends reworking batches due to a trace contaminant — going with a reliable supply chain now saves both time and resources later on.
It’s tempting to save a few dollars by switching to a “close enough” analog. But in projects I’ve managed, these shortcuts have often led to setbacks. A single misplaced halogen or amine can throw off the selectivity, yielding hard-to-separate mixtures or sapping yields. Worse, subtle impurities sometimes escape basic testing and emerge later, ruining expensive downstream steps.
Molecules like 2,3-dichloro-5-aminopyridine or 3-amino-4-chloropyridine often behave unpredictably, both in the lab and during scale-up. Problems range from lower solubility in reaction solvents to sluggish or uncontrollable reactivity with key electrophiles. Most chemists I know end up circling back to the original compound after a few failed runs with substitutes. It’s a classic case of “buy cheap, buy twice.”
Beyond direct substitutions, formulators sometimes experiment with blends or pre-reacted mixtures. From experience, these rarely beat the single-component approach, since unknown components can react unpredictably or introduce regulatory headaches.
As expectations rise for greener chemistry, every starting material comes under scrutiny. 3-Amino-2,5-dichloropyridine brings a track record of predictable disposal and well-documented pathways. Current best practice involves containment, minimal exposure, and efficient use — valuable habits for any synthetic effort. Documentation tracks its use through various regulatory regimes, from REACH to GHS, providing researchers confidence that compliance isn’t an afterthought.
Disposal protocols prioritize safety and environmental impact. Both academia and industry now track complete life cycles of intermediates, seeking ways to minimize waste and choose alternatives wherever possible. This molecule’s stability and predictable reactivity mean less accidental loss in work-up and fewer hazardous byproducts. From a sustainability perspective, researchers can plan for maximum atom economy and reduced energy inputs at each stage.
Running a synthetic campaign, surprises always come up. Some batches might show unexpected color, or react differently across seasons. To avoid slowdowns, many labs order extra analytical checks up front. Confirming melting point, purity, and residual solvent content catches most problems early. Scaling up for larger syntheses often exposes new bottlenecks, like clumping during weighing or slower dissolution. Fine-tuning solvent selection and maintaining consistent temperature help avoid these pitfalls.
Project delays sometimes trace back to logistical issues like import restrictions or haphazard planning. Reliable suppliers keep communication clear on lead times and available inventory. I’ve found success using staggered ordering and setting up “just-in-case” reserves for critical projects. Additionally, regular training for both seasoned and new lab members keeps everyone alert for storage and usage best practices.
On the technical side, careful monitoring of reaction conditions does more for yield than expensive equipment upgrades. Use in glovebox atmospheres or with added drying agents ensures sensitive steps go smoothly. Choosing compatible reagents — especially for substitutions at the amino or chloro positions — also speeds up troubleshooting. Peer networks and online forums often provide practical workarounds that don’t appear in the standard references.
As research pushes deeper into complex molecular targets, starting materials that combine flexibility with stability become more valuable. 3-Amino-2,5-dichloropyridine acts as one of those rare workhorses: approachable for established methods, adjustable for emerging needs. For example, recent work in C‒H activation and directed functionalization has highlighted the value of starting intermediates that offer both electron-donating and electron-withdrawing features.
Collaborations between academic teams and manufacturing partners have sped the optimization of production pathways, enabling more sustainable and affordable routes. We’re seeing more interest in process intensification, where intermediates like this can be used in flow synthesis, helping save energy and improve consistency. Researchers at the edge of medicinal chemistry and materials science look for intermediates ready to meet both the speed and traceability requirements of today’s demanding projects.
No research project thrives in isolation. Sharing hands-on experience with 3-Amino-2,5-dichloropyridine — from tips on recrystallization to unexpected interactions with new reagents — collectively raises the industry’s standards. Late-night discussions in lab offices, troubleshooting email chains, and conference poster sessions all help uncover better practices for making the most of each intermediate. Having firsthand stories about both routine and creative uses often carries more influence than data tables or official brochures.
Mentoring early-career chemists and emphasizing the significance of starting material choice not only saves money, but also drives the next wave of innovation. Collective wisdom about this aminodichloropyridine continues to grow, shared through publications, industry forums, and informal networks. The next breakthrough often comes from someone thinking outside the ordinary and passing along what worked — or what to avoid.
Looking back at dozens of projects where 3-Amino-2,5-dichloropyridine played a core role, the same themes keep surfacing. The practical realities of chemical research — tight budgets, pressure to deliver, rising quality standards — all tilt in favor of reliable, well-documented intermediates. You can shift your focus from troubleshooting each step to testing bold new ideas. The best results come not from fancy hardware, but from a deep understanding of the materials at your disposal.
On a personal note, I credit much of my productivity and fewest failed reactions to making careful, informed choices about inputs. This aminodichloropyridine proved to be more than just another item on the shelf — it offered peace of mind that each batch would move forward with fewer complications. Over time, those saved hours and reduced headaches add up, freeing resources and creativity for more rewarding pursuits.
As expectations keep rising in drug discovery, materials science, and agrochemical research, reliable intermediates serve as the gears that keep the machine running. Rigorous documentation, transparent quality assurance, and years of positive community experience all support confidence in this compound. Tangible benefits — fewer process hiccups, better batch reproducibility, easier troubleshooting — make it a staple for chemists looking for long-term progress over short-term convenience.
Choosing 3-Amino-2,5-dichloropyridine isn’t just a technical decision — it’s a sign of professional commitment to quality and progress. Colleagues, mentors, and project collaborators all recognize the impact that thoughtful choices in sourcing and use have on the bigger picture. For those working at the intersection of creativity and discipline — where every variable matters — proven intermediates like this one make the difference between routine work and groundbreaking achievement.
Innovation in science means smart use of both classic building blocks and new discoveries. 3-Amino-2,5-dichloropyridine brings reliability and versatility to the bench, helping researchers move from concept to completion with fewer delays and more success stories to share. It earns its place in the modern toolkit by delivering on the promises of consistency, adaptability, and safety — not just in theory, but every day in real laboratories around the world.
