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HS Code |
156749 |
| Chemicalname | 2-Hydroxy-4-methylpyridine-3-carbonitrile |
| Molecularformula | C7H6N2O |
| Molecularweight | 134.14 g/mol |
| Casnumber | 7547-12-6 |
| Appearance | White to off-white solid |
| Meltingpoint | 162-166 °C |
| Boilingpoint | No data available (decomposes) |
| Solubility | Slightly soluble in water; soluble in organic solvents |
| Density | No data available |
| Smiles | CC1=CC(=C(N=C1)O)C#N |
| Inchi | InChI=1S/C7H6N2O/c1-5-2-6(3-8)7(10)9-4-5/h2,4,10H,1H3 |
| Storagetemperature | Room temperature |
| Purity | Typically ≥98% |
| Refractiveindex | No data available |
| Synonyms | 2-Hydroxy-4-methyl-3-cyanopyridine |
As an accredited 2-Hydroxy-4-methylpyridine-3-carbonitrile factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | The chemical is supplied in a 25g amber glass bottle with a tamper-evident cap and detailed labeling for identification and safety. |
| Container Loading (20′ FCL) | 20′ FCL container loads approximately 12 MT of 2-Hydroxy-4-methylpyridine-3-carbonitrile, packed in 25kg fiber drums, securely sealed. |
| Shipping | **Shipping Description:** 2-Hydroxy-4-methylpyridine-3-carbonitrile is shipped in a tightly sealed container, protected from moisture and light. Packaged to prevent leakage or contamination, it is handled as a laboratory chemical. Ensure compliance with local and international transport regulations, using appropriate hazard labels and documentation if classified as hazardous. |
| Storage | Store **2-Hydroxy-4-methylpyridine-3-carbonitrile** in a tightly sealed container, kept in a cool, dry, and well-ventilated area away from incompatible substances such as strong oxidizers and acids. Protect from light and moisture. Ensure proper chemical labeling and restrict access to trained personnel only. Use secondary containment to prevent spills and maintain compliance with local regulations for hazardous chemicals. |
| Shelf Life | 2-Hydroxy-4-methylpyridine-3-carbonitrile is stable for at least 2 years when stored cool, dry, and protected from light. |
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Purity 98%: 2-Hydroxy-4-methylpyridine-3-carbonitrile with purity 98% is used in pharmaceutical intermediate synthesis, where high chemical yield and batch consistency are ensured. Melting point 164-166°C: 2-Hydroxy-4-methylpyridine-3-carbonitrile of melting point 164-166°C is utilized in agrochemical research, where thermal stability supports safe processing. Particle size ≤ 40 µm: 2-Hydroxy-4-methylpyridine-3-carbonitrile with particle size ≤ 40 µm is applied in catalyst development, where uniform dispersion improves reaction kinetics. Moisture content ≤ 0.5%: 2-Hydroxy-4-methylpyridine-3-carbonitrile with moisture content ≤ 0.5% is employed in fine chemical manufacturing, where low water content prevents hydrolytic degradation. Stability temperature up to 120°C: 2-Hydroxy-4-methylpyridine-3-carbonitrile stable up to 120°C is used in dye precursor formulations, where durability under processing conditions is critical. Residual solvent < 100 ppm: 2-Hydroxy-4-methylpyridine-3-carbonitrile with residual solvent < 100 ppm is used in electronics chemical fabrication, where low impurity levels enhance final product purity. |
Competitive 2-Hydroxy-4-methylpyridine-3-carbonitrile prices that fit your budget—flexible terms and customized quotes for every order.
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Manufacturing fine chemicals demands more than just precise formulas. It calls for reliable molecules, reproducible qualities, and consistency from the first kilogram to the last drum in the batch. In our chemical facility, we’ve learned these lessons through long hours on the plant floor and troubleshooting in synthesis labs. This is the lens through which we approach 2-Hydroxy-4-methylpyridine-3-carbonitrile, a pyridine compound that has seen steady growth in demand across pharmaceutical and specialty chemical sectors.
Long recognized for the versatility of its parent heterocycles, pyridine derivatives act as fundamental scaffolds in medicinal chemistry, agrochemical intermediates, and functional material development. Not all pyridine byproducts are built alike, even those with seemingly minor differences in substitution patterns. A methyl group on position four and a cyano group on position three provide a unique combination that influences reactivity and, later, the path of organic transformations. Our work as a direct producer brings a daily reminder that these distinctions can decide the fate of an entire production run.
Industrial routes to 2-Hydroxy-4-methylpyridine-3-carbonitrile need careful oversight of both product purity and upstream intermediates. We employ proprietary condensation and selective functionalization strategies, prioritizing consistent particle sizing and minimizing batch-to-batch variance. In practical terms, this means finished material that meets or exceeds 99% assay by HPLC, with controlled moisture and minimal heavy metal content.
Our experience has taught us that the small differences between an average synthetic grade and a truly research-ready material show up in subsequent steps. Product stability upon storage, solvent compatibility, and the effectiveness of recrystallization or downstream transformations depend as much on trace impurity profile as on headline assay numbers. Through years of iterative improvement, we track, analyze, and respond to even subtle process trends. This approach has dramatically reduced occurrences of off-spec product and strengthened relationships with our partners who rely on uninterrupted supply for time-sensitive projects.
Chemists often describe pyridine as a “privileged structure” due to its performance in both chemical reactivity and biological binding. Shifting the focus to this compound, adding a hydroxy group to the 2-position unlocks possibilities for targeted functionalization, salt formation, or bioconjugation. The 3-carbonitrile function brings additional synthetic leverage, allowing for transformations such as hydrolysis, reduction, or cycloaddition.
From a manufacturing standpoint, combining these motifs on the same ring requires careful process design. The hydroxy group enhances polarity, affecting solubility in common organic solvents. The nitrile introduces a sensitive, hydrolytically vulnerable point demanding low moisture environments post-synthesis. Efforts to simultaneously maximize yield and control trace impurity often become a central focus, especially for clients targeting regulated pharmaceutical applications.
Our downstream partners’ feedback has been invaluable. In serialization of heterocyclic intermediates, 2-Hydroxy-4-methylpyridine-3-carbonitrile offers better yields in metal-catalyzed couplings, particularly Suzuki or Buchwald-Hartwig types, compared against more heavily substituted analogues. Its moderate logP strikes a balance, giving decent solubility in polar and some non-polar media—key for those working with diverse reaction conditions. Researchers scaling pilot processes to manufacturing levels report that reproducibility stays high, a point we consistently validate through retention sample comparison and independent third-party QC checks.
The pharmaceutical sector’s strict adherence to standards filters back upstream to us. Impurities carried over from poorly controlled synthesis steps can derail drug discovery scale-up or result in regulatory rejection. Our team’s ability to trace every batch through robust documentation, retain critical QC records, and flexibly adjust purification parameters matches the on-the-ground realities faced by our users. The result is smoother project transitions and fewer lost hours to delayed investigations.
Across the catalog of pyridine derivatives, subtle choices matter. We produce related compounds such as 2-hydroxy-3-methylpyridine, 4-methylpyridine-3-carbonitrile, and 2-cyano-4-methylpyridine. While they share chemical ancestry, their behavior in both lab and plant settings diverges considerably from our 2-Hydroxy-4-methylpyridine-3-carbonitrile.
For instance, 2-hydroxy-3-methylpyridine lacks the activating nitrile group, which narrows its opportunities for further derivatization. 4-methylpyridine-3-carbonitrile removes the polarity boost the hydroxy group provides, often limiting solubility in mixed solvent systems. Feedback from contract development and manufacturing organizations (CDMOs) highlights that certain transformation pathways, especially those involving nucleophilic addition or transition-metal catalysis, fare better with our product’s dual substituents.
In large-scale applications, side product minimization stands as an everyday concern. We routinely observe that some analogues require additional recrystallization or chromatography, hampering throughput and inflating solvent costs. Experience tells us that cutting process steps without sacrificing purity translates to sharper delivery schedules and increased throughput for our partners. Supply chain interruptions caused by disappointing intermediate performance have even led a few large-volume users to switch entirely to our compound after protracted troubleshooting with less optimal alternatives.
Manufacturing specialties such as 2-Hydroxy-4-methylpyridine-3-carbonitrile doesn’t just mean maximizing personal or partner profit. It means facing today’s expectations for environmental accountability at each stage of the process. Since direct access to the plant floor, we’ve made incremental but meaningful improvements in energy use, solvent recovery, and waste stream management.
By engineering our processes around greener reagents and reusable catalyst systems, we not only comply with local regulations but also align ourselves with global objectives set by clients with rigorous sustainability charters. Each production campaign brings opportunities for yield optimization, and we actively solicit input on minimizing hazardous byproducts. We continue to document and share our progress on emission reductions, knowing that transparency builds trust with conscientious customers.
Having immediate oversight of operations removes unnecessary guesswork. Our chemists and process engineers work together to run small-scale optimization trials before launching a new large production campaign. Adjustments based on insight from our previous batch records—sometimes as granular as modifying pH adjustment rates or the order of additions—can make the difference between hour-long cleanups and seamless batch turnovers.
Not every facility has the luxury of this feedback loop. Being embedded in both development chemistry and full-scale production, we close the gap between theoretical ideal and practical output. This focus has led to measurable improvements in both product stability and on-time shipments, which our partners tell us is one reason they trust us with complex and urgent projects.
Scale-up from multi-gram to multi-ton production rarely follows a linear path. Solubility variance between hot and cold process steps introduces challenges for both filtration and crystallization. Some customers chasing even higher purities requested tweaks in seeding protocols or mother liquor recycling—modifications that directly arose from open dialog and responsive technical service.
Process safety cannot rest on yesterday’s parameters. Thermal profiles that seem manageable on kilogram scale sometimes require entire retooling on 500 kg runs. Over the years, we have invested in pilot plant modeling to keep exotherm control and pressure management within tightly defined boundaries. This effort has prevented near-misses and kept regulatory bodies satisfied during regular inspections.
Auditors and customers alike ask pointed questions about batch history, trace contaminant profiles, and unexpected byproducts. We treat each request as an opportunity to demonstrate that our controls go beyond minimum compliance. Our documentation system tracks not just production parameters but stores parallel analysis from release and retain samples, flagging deviations sooner and making data retrieval straightforward.
This focus on traceability gets put to the test in cases where clients seek retrospective verification for regulatory filings or patent defense work. We’ve expedited data requests within hours instead of days, thanks to this living archive. Knowing that their compliance burden shrinks drives repeat business and longer term collaborations.
A trend we’ve identified over years of working closely with R&D groups and process chemists: the more reliable the starting material, the more successful downstream innovation becomes. Product quality wavers, and suddenly whole campaigns sit idle, waiting on requalification or complaint investigation. With 2-Hydroxy-4-methylpyridine-3-carbonitrile, maintaining a steady, reproducible profile fuels confidence, letting users focus their creativity and expertise where it matters most. Our customer base of research-based pharmaceutical companies, independent chemical developers, and academic innovators all demand this.
It’s not only about the molecule’s core performance. Specific end-use projects have cited our work in critical patent filings or regulatory submissions, recognizing that the batch-specific analytical support and technical troubleshooting we provide helps fill in crucial data gaps. In a marketplace where timelines for development shorten each year, those practical, relationship-based supports often mean more than glossy brochures or generic promises.
Storage and handling play a surprisingly large role in how well a specialty intermediate performs after it leaves the factory. Our facilities prepare product under dry, inert atmosphere to preserve the nitrile and limit potential hydrolysis. Standard drum and high-barrier packaging undergo suitability testing for compatibility and extractable analysis before approval.
Once in customers’ hands, shelf-life meets published promises if local warehousing and environmental controls mirror best practices we’ve mapped out. Regular quality feedback cycles ensure that product approaching expiration doesn’t suddenly compromise rush projects. We support resampling and retesting on request, respecting our clients’ need to maintain audit-ready documentation for all supplied batches.
Having production under our direct care brings us into daily, sometimes hourly, conversation with users experiencing system bottlenecks or troubleshooting reaction problems. Over the years, dialogue with research teams has driven incremental improvements—whether adjusting physical form, refining color targets, or providing variant particle sizes for specialized reactors.
By approaching each project as a partnership rather than a simple transaction, we work side by side with those facing commercial deadlines, regulatory hurdles, or unanticipated process issues. This collaborative attitude has proved particularly valuable during market upswings and demand spikes, where speed and agility make or break delivery schedules.
To us, every synthesized kilogram represents a story—weeks or months of planning, safety reviews, and optimization. We see downstream breakthroughs and regulatory wins by our partners as a real win for our own crew’s dedication and expertise.
The specialty chemical landscape never stays static. Regulatory requirements keep evolving and the bar for both environmental impact and human safety keeps ticking upward. Our site regularly invests in process intensification projects. Over the past five years alone, we automated high-throughput analytical screening, improved filtration platforms, and transitioned as many processes as practical to reduced-solvent or solvent-free conditions.
Rapid data sharing with client technical teams means ongoing learning flows both directions. We pilot greener reaction media, test next-generation purification aids, and launch research-scale trials based directly on evolving user feedback. This dynamic approach doesn’t end with successful order completion—the lessons learned from each campaign feed back into the next.
As specialists in intermediates manufacturing, we recognize the central point: Supplying 2-Hydroxy-4-methylpyridine-3-carbonitrile is never just about a bottle or a drum. It’s about expertise, mutual trust, and an ongoing commitment to quality and safe production standards. Whether supporting the next wave of antiviral research or facilitating a new industrial catalyst, we are ready to shape solutions with our partners, one batch at a time.
