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HS Code |
535491 |
| Iupac Name | 2-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine |
| Molecular Formula | C8H8ClN |
| Molecular Weight | 153.61 g/mol |
| Cas Number | 1025526-41-5 |
| Appearance | Colorless to pale yellow liquid |
| Density | Approx. 1.15 g/cm³ (estimated) |
| Solubility | Slightly soluble in water, soluble in organic solvents |
| Smiles | Clc1ncccc2CCCC12 |
| Inchi | InChI=1S/C8H8ClN/c9-7-5-6-3-1-2-4-8(6)10-7/h5H,1-4H2 |
| Storage Conditions | Store in a cool, dry, and well-ventilated place |
As an accredited 2-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Amber glass bottle containing 25 grams of 2-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine, sealed with a tamper-evident cap. |
| Container Loading (20′ FCL) | 20′ FCL container holds securely packaged 2-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine drums, ensuring safe bulk chemical transport. |
| Shipping | Shipping for **2-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine** requires secure, leak-proof packaging, compliant with local and international regulations. The product should be transported in labeled, chemically compatible containers with appropriate hazard communication. Shipments must include safety data sheets and follow guidelines for handling organic compounds, ensuring protection from extreme temperatures and physical damage. |
| Storage | 2-Chloro-6,7-dihydro-5H-cyclopenta[b]pyridine should be stored in a tightly sealed container, kept in a cool, dry, and well-ventilated area away from direct sunlight, heat sources, and incompatible materials (such as strong oxidizers). Store it at room temperature, or as recommended on the safety datasheet. Handle with appropriate personal protective equipment and follow all relevant safety protocols. |
| Shelf Life | Shelf life for 2-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine is typically 2 years when stored in a cool, dry place. |
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Purity 98%: 2-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine with purity 98% is used in pharmaceutical intermediate synthesis, where it ensures high-yield conversion rates. Melting Point 44-46°C: 2-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine at melting point 44-46°C is used in organic reaction processes, where its controlled phase transition improves process consistency. Molecular Weight 167.64 g/mol: 2-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine with molecular weight 167.64 g/mol is used for compound library building in medicinal chemistry, where it facilitates accurate stoichiometric calculations. Stability Temperature up to 120°C: 2-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine with stability up to 120°C is used in high-temperature catalytic applications, where thermal robustness minimizes decomposition. Particle Size <10 μm: 2-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine with particle size less than 10 μm is used in formulation of tablet blends, where it enhances homogeneity and dissolution rates. Assay ≥99%: 2-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine with assay ≥99% is used in analytical standard preparation, where it provides precise quantitation for quality control. Storage Stability 24 months: 2-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine with storage stability of 24 months is used in bulk chemical storage, where prolonged shelf life reduces material wastage. |
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For many in the fine chemicals industry, finding a stable, versatile building block for synthesis can make all the difference in research and manufacturing projects. We manufacture 2-chloro-6,7-dihydro-5H-cyclopentapyridine because it helps advance various sectors, from pharmaceuticals to agricultural development. Over the years, we have fine-tuned each step in the manufacturing process, addressing the demand for both high purity and reproducibility in performance. Plenty of products out there claim reliability, but experience shows that real-world consistency hinges on hands-on chemical expertise, process control, and careful attention to impurities.
Compared to more basic pyridine derivatives, this compound introduces a saturated cyclopenta ring fused to the pyridine core, along with a chlorine atom at the 2-position. This arrangement opens up reactivity unique to this molecule, not seen in unsubstituted or more heavily halogenated analogues. Chemists working with other fused-ring pyridines often run into issues with solubility or downstream reactivity. Our customers often share feedback on how its structural distinctiveness lets them reach targets that were inaccessible with other common substrates.
Production of 2-chloro-6,7-dihydro-5H-cyclopentapyridine usually starts with careful selection of starting materials and close control of reaction conditions. Only dedicated equipment, trained operators, and tight process management prevent formation of byproducts that can challenge downstream purity or yield. We monitor reaction kinetics, solvent selection, and catalyst loadings throughout each batch, based on data from years of production cycles. Small tweaks, like temperature ramp timing or quench procedure, dramatically affect the impurity profile. Some labs underestimate these steps, but overlooked detail often means the difference between a passable intermediate and a reagent grade product.
Our quality control lab keeps a sharp eye on parameters like water content, residual solvents, and isomer ratios. Since this molecule's aromatic and partially saturated framework tends to attract both nucleophiles and oxidation risks, we regularly inspect shelf life and storage stability. Reliable supply grows from repeated experience with these technical challenges, not just batch reproducibility, but logistical execution as well. Experience teaches that it's better to under-promise on batch lead times than to cut corners. Customers running costly syntheses downstream deserve transparency about what to expect, and we keep the line of communication open if an unexpected factor affects a production run.
Chemically, 2-chloro-6,7-dihydro-5H-cyclopentapyridine fills a gap left by classic pyridines and simpler cyclopentapyridine compounds. The chlorine at C-2 allows targeted substitutions that can direct reactivity in ways unavailable to the parent fused-ring system. For research teams exploring heterocycle functionalization, this distinction enables new synthetic paths. Its partial saturation lets it maintain a sweet spot between rigidity and flexibility, which in turn influences physicochemical behavior in both organic and aqueous systems.
Handling this compound requires less hassle than some of its close relatives. We work to minimize batch-to-batch variation in melting point and color, reporting these properties to clients who value process predictability. Compared with monosubstituted cyclopenta-pyridines lacking a halogen, the presence of the chlorine atom translates to different charge distribution and altered electron density, countering certain side reactions that can plague halide-free options. Downstream, this molecule gives medicinal chemists more predictable pathways for palladium-catalyzed coupling or nucleophilic substitution, streamlining discovery and lead optimization work.
We have compared our product with both imported and domestic alternatives available on the open market. Simple visual inspection and more advanced chromatographic analysis reveal that many commercial stocks accumulate minor byproducts over time or suffer from inconsistent color and odor. Purity tells only half the story; impurity profile makes up the other half, and too many suppliers focus only on listed assay percentages. In the lab, we have demonstrated that trace byproducts from insufficient quenching or poor crystallization can carry through to later synthesis steps and cause unexpected chromatographic surprises for users down the line.
Pharmaceutical R&D teams pick this molecule as a building block, especially for alkaloid analogues and heteroaromatic scaffolds that require controlled electronic effects. We see both small biotech labs and mid-size pharma customers returning for repeat orders because it lets them avoid excessive protection and deprotection steps. A streamlined pathway saves not just time but operational costs. In crop protection chemistry, several firms prefer this product as a precursor for designing selective modulators that interact with biological receptors at specific sites, drawing on the unique balance between rigidity and reactivity provided by the molecule's fused skeleton and chlorine substituent.
Experienced chemists know that having access to a consistent supply of this pyridine derivative can mean the difference between smooth process development and months lost troubleshooting purification issues. We often talk shop with teams facing problems amplifying scale from milligram to kilogram lots. Even minor discrepancies in impurity content, particle size, or residual moisture can trigger major delays. We build long-term relationships with clients by addressing those specifics—what works for a bench chemist does not always scale to what a plant needs. Our technical team shares firsthand data on solubility in different systems and works with process engineers to optimize batch formulation and handling.
Years of production experience have taught us that handling convenience matters nearly as much as chemical performance. We provide 2-chloro-6,7-dihydro-5H-cyclopentapyridine in packaging designed to reduce exposure to moisture and air, which limits degradation and keeps content consistent through storage and transport. Common requests from power users include custom particle size or container type, and we work directly with end users to build in features that mimic their exact workflow. It's common for a lab to want single-use bottles during research, then shift to multi-kilogram pails for pilot scale runs; we have responded to both. This responsiveness comes not just from off-the-shelf packaging, but constant dialogue with those who use the compound in real-world scenarios.
Some customers worry about safety and handling for sensitive intermediates. We think about stability not only in the warehouse, but in unpredictable field conditions too. Our packaging line goes through regular checks, from sealing quality to inert gas backfilling where necessary. Since even trace water can trigger decomposition, we keep water content well below industry-accepted thresholds. We track feedback and make adjustments—if a chemist down the line notices unexpected discoloration, our QA team traces the root cause and fine-tunes protocols for future batches.
Feedback from our clients drives the evolution of our process. No one-size-fits-all solution meets every need, so we keep close contact with process chemists, R&D teams, and pilot plant engineers to understand not just what works, but what can be improved. Regular updates on production batches and impurity profiles have helped several collaborators adjust their own synthetic procedures, avoiding common pitfalls when transitioning from laboratory synthesis to full-scale production.
We believe in transparency and practical support. If something can affect the integrity of the product—whether it be batch-to-batch consistency, storage lifespan, or shipping logistics—we share that with the people who depend on our chemistry. Over the years, companies have told us they value not just a reliable supply, but also honest feedback and technical troubleshooting. For example, one project with a pharmaceutical partner revealed an unforeseen side reaction at scale, traced to a minor impurity. By revising our purification step, we prevented the same issue in future lots, cutting the customer’s troubleshooting time and development costs nearly in half.
The difference between a product that meets minimum assay and one that provides real operational value comes from the depth of manufacturing experience. We invest in both technology and training, running routine and non-routine analysis on all outgoing stock. Methods go well beyond just HPLC or GC; we employ NMR, mass spectrometry, and even recently developed analytical tools to map out the full impurity fingerprint. The outcome for users is less worry about unexpected reactivity, and more strategic use of the compound for pioneering chemical innovation.
Customers sometimes ask what sets our 2-chloro-6,7-dihydro-5H-cyclopentapyridine apart from competitors. Beyond basic purity, we offer batch histories and traceability, and our technical support draws from actual manufacturing experience, not just theoretical know-how. The field is moving toward stricter standards for trace contaminants and sustainability, and we are ahead of the curve by incorporating green chemistry principles where possible—minimizing waste, optimizing energy input, and focusing on safe handling from plant to end user.
We actively support research-stage projects as well as mature industrial users. For teams pushing into new frontiers—late stage intermediates, unique active ingredients, or advanced material synthesis—our product provides a launchpad for creativity and exploration. We understand day-to-day realities like the impact of batch scheduling or the ripple effects of production delays. Failures in the supply of a key intermediate like this disrupt timelines in ways that pure theory misses. Reliable chemistry comes from the teamwork between manufacturer and user, and our history shows that open exchange—backed by detailed, practical expertise—yields the best technical outcomes.
As a manufacturer, we see firsthand how new regulations and technical standards influence market expectations. More customers want full impurity profiles, background on environmental footprint, and assurances about long-term availability. We don't just follow the minimum; we engage with industry groups and technical conferences to adapt our practices and stay informed on relevant changes. With each advance, we communicate transparently how it affects product quality and user experience.
Chemistry develops at the intersection of manufacturing excellence, scientific insight, and customer feedback. Working with our clients has highlighted points of improvement, from process optimization to more robust packaging. Small refinements, made in response to lived experience—like redesigning a bottle cap that resisted resealing or tightening moisture control—add up to more effective research and smoother industrial processes.
Long-term reliability defines value more than any single parameter. We keep records of all changes and customer feedback, audit production batches, and fine-tune our analytical approach to meet and exceed industry expectations. Case examples abound: One agricultural R&D partner documented a problem with solubility in a new formulation, traceable to changes in the carrier solvent. By collaborating on stability testing, we helped them reformulate their end product, opening a new pathway for their business.
We believe every intermediate should serve not just as a static building block, but as a gateway to greater chemical innovation. By keeping a hands-on approach and engaging with real-world applications, we push the boundaries of quality and safety.
2-chloro-6,7-dihydro-5H-cyclopentapyridine continues to prove itself through real-world usage—whether that means getting a research program off the ground, accelerating a scale-up, or enabling a new active ingredient discovery. Its versatility and profile support innovation, but it’s our manufacturing experience and customer-focused approach that turn a molecule into a practical solution. Vigilant process monitoring, honest problem-solving, and open sharing of technical knowledge prepare us to meet future challenges. Each ton produced carries the lessons learned from years of hands-on synthesis, industrial partnership, and ongoing refinement—supporting scientists, engineers, and product teams with chemistry they can trust.
