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HS Code |
664513 |
| Chemical Name | 2-Chloro-5-Hydroxypyridine |
| Cas Number | 1193-24-4 |
| Molecular Formula | C5H4ClNO |
| Molecular Weight | 129.55 |
| Appearance | White to light yellow solid |
| Melting Point | 112-116°C |
| Boiling Point | 285°C (estimated) |
| Solubility In Water | Moderate |
| Density | 1.38 g/cm³ (estimated) |
| Smiles | C1=CC(=NC=C1Cl)O |
| Iupac Name | 2-chloro-5-hydroxypyridine |
| Storage Conditions | Store at room temperature, keep container tightly closed |
| Purity | Typically ≥98% |
| Synonyms | 2-Chloro-5-pyridinol, 5-Hydroxy-2-chloropyridine |
| Refractive Index | 1.611 (estimated) |
As an accredited 2-Chloro-5-Hydroxypyridine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | A 25g amber glass bottle securely sealed, labeled "2-Chloro-5-Hydroxypyridine," with hazard warnings and product details for laboratory use. |
| Container Loading (20′ FCL) | Container Loading (20′ FCL) for 2-Chloro-5-Hydroxypyridine: 12 metric tons packed in 25 kg fiber drums, securely palletized for export. |
| Shipping | 2-Chloro-5-Hydroxypyridine is shipped in tightly sealed containers to prevent moisture and contamination. Packaging complies with international transport regulations for chemicals. The container is labeled with hazard and handling information. Appropriate cushioning materials are used to minimize breakage during transit. Shipment is via ground or air, depending on destination and urgency. |
| Storage | 2-Chloro-5-hydroxypyridine should be stored in a tightly closed container, in a cool, dry, well-ventilated area away from sources of ignition and incompatible substances such as strong oxidizers and acids. Protect from moisture and direct sunlight. Store at room temperature or as specified by the manufacturer. Ensure all containers are clearly labeled, and avoid prolonged exposure to air to prevent degradation. |
| Shelf Life | 2-Chloro-5-Hydroxypyridine typically has a shelf life of 2-3 years if stored in a cool, dry, tightly sealed container. |
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Purity 99%: 2-Chloro-5-Hydroxypyridine with purity 99% is used in pharmaceutical intermediate synthesis, where it ensures high yield and consistent product quality. Melting Point 180°C: 2-Chloro-5-Hydroxypyridine at melting point 180°C is used in agrochemical formulation development, where it provides thermal stability during processing. Particle Size <10 μm: 2-Chloro-5-Hydroxypyridine with particle size below 10 μm is used in fine chemical applications, where it facilitates uniform dispersion and reactivity. Molecular Weight 131.55 g/mol: 2-Chloro-5-Hydroxypyridine with molecular weight 131.55 g/mol is used in laboratory-scale organic synthesis, where it allows precise stoichiometric calculations. Stability Temperature up to 150°C: 2-Chloro-5-Hydroxypyridine with stability temperature up to 150°C is used in heated reaction systems, where it maintains chemical integrity under prolonged thermal exposure. Assay ≥98% (HPLC): 2-Chloro-5-Hydroxypyridine with assay ≥98% (HPLC) is used in API production, where it ensures compliance with strict purity requirements for regulatory approval. |
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Today’s research labs and production sites both depend on a steady supply of building blocks that lay the groundwork for advanced molecules. Among these, 2-Chloro-5-Hydroxypyridine comes up time and again for its role in pharmaceuticals, agrochemicals, and specialty chemical creation. I remember digging into lab work years ago, and it struck me how certain compounds provide not just a starting point, but real leverage in designing outcomes that demand reliability and precision.
The real heart of this compound—model number C5H4ClNO—stems from its unique blend of reactivity and selectivity. The molecular structure brings together both a chlorine atom at the 2-position and a hydroxyl group at the 5-position on a pyridine ring. This pairing opens up specific reaction routes that you simply don’t get with either mono-substituted pyridines or with their close relatives lacking both groups. Standard laboratory practice often highlights the significance of this arrangement. I have seen researchers turn to this material precisely because the mix supports targeted transformations without dragging in too many side products; that saves time, reduces purification costs, and brings scalability within reach more easily than some alternatives.
Years of handling chemical raw materials shows one thing: even small differences in purity make or break an entire project. Suppliers will talk about purity ranges around the 98% mark for 2-Chloro-5-Hydroxypyridine, with lower impurity levels in key metrics like water content and heavy metal traces. Having reliable figures here does more than inspire confidence—each researcher, production manager, and quality reviewer knows their batches behave the same way from order to order. That predictability stands at the crossroads of practical chemistry and real-world results.
Practical chemists reach for this compound for a few clear reasons. In the pharmaceutical world, it helps create molecules that can block or trigger key pathways in the body by providing a versatile scaffold for further derivatization. In crop science, the same structural qualities open up new options for metabolic stability and selective bioactivity. Reflecting on my own collaborations with formulation teams, I have seen 2-Chloro-5-Hydroxypyridine pop up in key synthetic steps where neither simple chloropyridines nor solely hydroxylated rings delivered the reactivity or selectivity needed to push the project forward. That experience reinforces how a well-chosen intermediate shapes both speed and success.
Think about pyridine derivatives in general: you have options like 2-Chloropyridine, 3-Hydroxypyridine, or 5-Chloropyridine. None of those manage the particular pairing of electron-withdrawing and electron-donating groups you get here. That matters in real-world synthesis. For example, attempts to swap in a mono-substituted alternative sometimes force harsher conditions or lead to messy product streams that need extra cleanup. I recall one synthesis project where dropping the hydroxyl group at the 5-position led to frustrating unpredictable byproducts, driving up the cost and slowing our discovery efforts.
Small-scale reactions in the lab can paint an optimistic picture, but questions around scalability remain until raw material performance is proven under manufacturing conditions. Chemical manufacturers face persistent challenges around consistency and yield. From my experience, 2-Chloro-5-Hydroxypyridine demonstrates a level of manageability that’s welcome on the production floor. Batch-to-batch reproducibility, ease of handling, and robust reactivity translate to fewer surprises, lighter process troubleshooting, and better compliance with regulatory expectations.
Recent years brought increasing attention to workplace safety and environmental stewardship in chemical industries. Handling 2-Chloro-5-Hydroxypyridine brings the usual chemical hygiene practices—appropriate PPE, fume hoods, and effective ventilation—into focus. People on the ground want to know not just if a material gets the job done, but if they can do their job with confidence and peace of mind. Based on established reports, this compound lines up with other specialty chemicals in terms of safe management, as long as staff are trained and monitoring practices are in place.
Nobody enjoys gaps in the supply chain. Disruptions delay launches, drag down profits, and add stress to already-tight schedules. Over the past ten years, supply of niche intermediates like 2-Chloro-5-Hydroxypyridine has grown sturdier, thanks to better logistics and increased production capacities worldwide. Still, buyers need to pay attention to supplier quality, regulatory status, and long-term commitment to avoid the pain of last-minute substitutions or compliance snags. With multiple reliable manufacturers in the market today, it’s possible to lock in steady deliveries, provided those relationships are well cultivated.
Trusting specs on paper without real verification rarely delivers results worth repeating. I’ve learned the value of setting up rapid screening methods—whether by HPLC, NMR, or TLC—to check incoming 2-Chloro-5-Hydroxypyridine for off-spec batches before use in high-value projects. A bad lot rarely stays hidden for long, and robust incoming inspection protocols weed out surprises before they eat into time, budgets, or downstream material.
Storage doesn’t attract much attention until degraded batches show up at the wrong moment. My practice has shown that keeping 2-Chloro-5-Hydroxypyridine sealed against moisture and away from heat stabilizes the product and limits surprises. As with many lab chemicals, regular checks for color change or clumping provide solid early-warning signals for quality losses. Long shelf life ultimately means fewer emergencies, less waste, and more predictable inventories for research programs or scaled-up production.
Growing pressure for greener processes highlights questions around how building blocks like this are made and disposed of. While 2-Chloro-5-Hydroxypyridine production runs on conventional chemistry, there’s growing movement toward solvent recovery, minimization of hazardous waste, and recycling raw materials. Some process advances—like improved chlorination techniques or more selective catalysis—have nudged the needle on both yield and environmental impact. The industry’s next steps in greener pyridine chemistry will rely on close partnerships between producers, users, and regulators.
Not every lab or factory wants the same form. Most users opt for solid crystals, which allow for easier transfers and weigh-outs with fewer risks of airborne exposure. For larger-scale applications, tailored particle size helps with dosing in automated systems, avoiding clogging or inconsistent feed rates. These options, based on real feedback from production teams, aim to make daily handling both manageable and predictable. Lowering the risk of spills and exposure pays off in employee satisfaction and process continuity.
Chemistry teams often debate swapping out intermediates, seeking cheaper or more available substitutes. Results tend to confirm the value of getting both a chlorine and hydroxyl group in the right places on the pyridine ring. Using 2-Chloropyridine or 5-Hydroxypyridine alone can push reactions into unpredictable territory or force less efficient steps. The subtlety of substitution effects turns out to be more than just a textbook difference; it shows up in actual time spent troubleshooting and in the final quality of end products. Those details, learned through hands-on experience, shape the real-world utility of these building blocks.
Modern chemical workplaces are built around safety standards and clear compliance with regional regulations on handling, transportation, and waste. Based on current literature, 2-Chloro-5-Hydroxypyridine fits within handling bands managed by chemical process safety protocols. Workers tend to approach it with routine respect, relying on PPE and established cleanup measures for spills and accidental contact. Ongoing safety training and open communication with environmental health and safety teams remain the backbone of successful and incident-free use, as seen across a range of organizations.
The push for new molecular entities in pharmaceuticals and crop protection hinges on robust intermediate steps. Over the past decade, medicinal chemistry groups have unlocked new drug candidates and advanced synthetic routes thanks to the easy functionalization made possible by 2-Chloro-5-Hydroxypyridine. Lab teams often cite the speed and cleanliness with which modifications can be made on the pyridine core, opening doors that more inert alternatives keep shut. In my own projects, the difference between a setback and a breakthrough often came down to selecting the right scaffold at the right moment.
Intellectual property portfolios in synthetic chemistry depend in large part on novel uses and new methods using specific intermediates. With 2-Chloro-5-Hydroxypyridine, unique derivatives and patented synthetic steps have created real competitive advantages. The flexibility of the molecule as a launching pad for complex projects directly translates to value both in proof-of-concept exploration and in commercial manufacturing. Patent records over the last decade reflect its significant, if understated, impact on winning chemical innovations.
Automation and flow chemistry setups reward predictable behavior in raw materials. From feedback shared by colleagues in pilot plants, 2-Chloro-5-Hydroxypyridine demonstrates compatibility with continuous flow reactors and automated dosing systems, keeping process bottlenecks at bay. This real-world performance supports the integration of advanced synthetic methods and tighter process control, helping the industry meet rising productivity targets and tight regulatory standards.
Not every bottle of chemical tells the truth on its label. Stories circulate of off-grade material finding its way into research and production batches, causing headaches and losses. Strict procurement guidelines, supplier audits, and in-house testing play a vital role in keeping standards high and counterfeits out of the supply chain. Project timelines and budgets owe much to this commitment to vigilance, which defines the ethos behind reliable and responsible chemical sourcing.
Consideration of the full lifecycle of chemicals has become more important, both for regulatory reasons and for sustainable practices. In day-to-day use, most operations aim to keep waste generation low and collection efficient, following guidelines for pyridine derivatives. Emerging best practices encourage lab-scale neutralization or dedicated incineration for any unusable residues. Waste management, once an afterthought, has become a routine part of responsible handling over the life of each batch.
While data sheets and catalogs give an initial sense of a product, professional judgment fills in the gaps normally absent from marketing materials. Across a decade of working with specialty chemicals, I’ve seen decisions shaped by field-tested feedback—whether around reactivity under odd conditions or the way a particular impurity type can ripple through downstream yields. These shared insights bolster user confidence and produce faster, more reliable results on complex syntheses.
Modern workflows bring together purchasing teams, chemists, and project leads from the start of each project cycle. Planning discussions often feature logistics, cost, reactivity, and stock levels in equal measure. Reliable raw material performance, reflected in the choice to source 2-Chloro-5-Hydroxypyridine from trusted partners, supports the shared mission of smooth project execution and timely delivery of new products.
As innovation in fine chemical synthesis accelerates, foundational intermediates must adapt to new requirements and higher standards. Ongoing research into process safety, sustainability, and advanced automation will shape the route forward. Input from hands-on users—feedback based on real trial and error—will remain the most valuable driver behind further progress in the sourcing, use, and optimization of compounds like 2-Chloro-5-Hydroxypyridine.
Continuous progress in synthetic methodology and green chemistry holds promise for even broader application. Improvements in catalysis, purification technology, and minimal-waste production stand poised to shape the next decade of how this building block gets used and produced. Cross-industry dialogue—pulling together voices from bench, plant, and management—will keep solutions focused and practical. Industry participants who invest in learning from both successes and failures secure a stronger position, benefiting future efforts and bottom-line outcomes.
Stepping back, the journey of 2-Chloro-5-Hydroxypyridine in the chemical supply chain reflects much of what makes modern science and industry tick. Reliable basics build the foundation for new ideas, while openness to innovation and fidelity to rigorous practice decide future gains. Whether tasked with scaling an experimental synthesis or problem-solving a stuck process, teams find real value in knowing they have consistent, dependable intermediates at their disposal. In an era shaped by both progress and scrutiny, those who build on this foundation stand ready to meet the challenges ahead.
