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HS Code |
315171 |
| Product Name | 2-Chloro-3-Methyl-5-fluoropyridine |
| Cas Number | 250482-13-2 |
| Molecular Formula | C6H5ClFN |
| Molecular Weight | 145.56 g/mol |
| Appearance | Colorless to pale yellow liquid |
| Boiling Point | 170-174°C |
| Density | 1.29 g/cm³ |
| Purity | Typically ≥98% |
| Refractive Index | 1.523 |
| Solubility | Slightly soluble in water, soluble in organic solvents |
| Flash Point | 60°C |
| Storage Conditions | Store in a cool, dry place, tightly closed |
| Smiles | CC1=C(N=CC(=C1)Cl)F |
| Inchi | InChI=1S/C6H5ClFN/c1-4-5(8)2-3-9-6(4)7 |
As an accredited 2-Chloro-3-Methyl-5-fluoropyridine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Amber glass bottle, 100 grams, with tamper-evident cap, hazard labeling, product name, chemical formula, and manufacturer’s details securely displayed. |
| Container Loading (20′ FCL) | Container Loading (20′ FCL): 2-Chloro-3-Methyl-5-fluoropyridine is packed in 200kg/drum, total 80 drums, approximately 16MT net weight. |
| Shipping | 2-Chloro-3-Methyl-5-fluoropyridine is shipped in tightly sealed containers, protected from moisture and light. It is typically transported as a hazardous material in compliance with local and international regulations. Proper labeling, documentation, and handling by trained personnel are required to ensure safe transit and delivery. Store in a cool, well-ventilated area upon receipt. |
| Storage | 2-Chloro-3-Methyl-5-fluoropyridine should be stored in a tightly closed container, in a cool, dry, well-ventilated area away from sources of ignition and incompatible substances such as strong oxidizers. Protect from moisture and direct sunlight. Store under inert atmosphere if necessary, and ensure proper labeling. Follow all relevant chemical safety and storage regulations to prevent spillage or accidental exposure. |
| Shelf Life | 2-Chloro-3-Methyl-5-fluoropyridine is stable under recommended storage conditions; shelf life is typically 2-3 years if unopened. |
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Purity 99%: 2-Chloro-3-Methyl-5-fluoropyridine with purity 99% is used in pharmaceutical intermediate synthesis, where it ensures high yield and reduced impurity formation. Melting Point 42–45°C: 2-Chloro-3-Methyl-5-fluoropyridine with melting point 42–45°C is used in organic synthesis processes, where it facilitates easier handling and controlled crystallization. Molecular Weight 147.56 g/mol: 2-Chloro-3-Methyl-5-fluoropyridine with molecular weight 147.56 g/mol is used in agrochemical manufacturing, where it enables precise stoichiometric calculations for active ingredient formulation. Stability Up to 70°C: 2-Chloro-3-Methyl-5-fluoropyridine with stability up to 70°C is used in industrial storage and transport, where it provides safe material handling under standard processing conditions. Particle Size <50 µm: 2-Chloro-3-Methyl-5-fluoropyridine with particle size below 50 µm is used in catalyst preparation, where it promotes uniform dispersion and increased reactivity. Water Content <0.5%: 2-Chloro-3-Methyl-5-fluoropyridine with water content less than 0.5% is used in moisture-sensitive reactions, where it supports optimal product stability and reaction efficiency. Assay ≥98% (GC): 2-Chloro-3-Methyl-5-fluoropyridine with assay ≥98% (GC) is used in chemical reference standard preparation, where it guarantees analytical accuracy and reproducibility. |
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2-Chloro-3-Methyl-5-fluoropyridine offers something that chemists and manufacturers care about deeply: consistent results and versatility in synthesis. In the crowded field of pyridine derivatives, small changes can open up new strategies for modern chemistry, especially when working on pharmaceuticals or cutting-edge materials. This compound’s structure gives it several advantages over some of the classics in this space.
Talking with colleagues who work in process development, there's always someone asking which building block works best for a certain heterocycle scaffold. Many have drifted to 2-Chloro-3-Methyl-5-fluoropyridine because it brings together a unique trifecta: the chlorine on position 2, methyl on position 3, and fluorine on position 5. This specific substitution pattern allows for a wider set of reactions. For instance, the chlorine atom is a strong candidate for nucleophilic aromatic substitution, letting chemists install other groups where needed. Both methyl and fluorine influence the electron density on the ring, impacting reactivity and selectivity in downstream transformations.
A lot of times, labs need to avoid reagents that require harsh conditions or extra clean-up steps. 2-Chloro-3-Methyl-5-fluoropyridine usually delivers purity above 98%. Consistent specifications mean that synthetic routes aren’t thrown off by surprise side-products or variable color and solubility.
Chemists can rely on a compound like this when every reaction matters. This pyridine derivative typically comes as a clear to pale yellow liquid, easy to handle even in larger batches. Boiling point lands in the expected range, which lines up well with troubleshooting distillations and solvent choices. Its molecular weight (around 147 g/mol) simplifies calculations for scale-ups. I remember times in the lab where an impurity caused a whole synthesis campaign to stall — precise, repeatable melting and boiling points go a long way to stop those headaches before they start.
On the analytical side, verifying the structure by NMR or GC/MS is straightforward thanks to its three distinctive substituents. The fluorine atom (5-position) shows up clearly in both NMR and mass spectrometry, making it easier to track through any route, whether by academic research groups or pharmaceutical quality-control teams.
People sometimes see fine chemicals as abstract, but the role they play is direct and practical. 2-Chloro-3-Methyl-5-fluoropyridine serves as a strong intermediate in active pharmaceutical ingredient synthesis, especially when medicinal chemists aim to introduce complex functional groups with specificity. Fluorine-containing heterocycles appear more in drug candidates partly due to improved metabolic stability and bioavailability. In personal experience and papers I have read, swapping out other pyridines for this one often brings higher yields or cleaner products — both highly valued on the bench and in pilot plants.
Beyond pharma, agrochemical developers turn to materials that help achieve new modes of action. Pyridines play an important part in pesticides, herbicides, and fungicides. Changing one position on the ring can create a new active molecule or extend patent life. In a world where crop losses put pressure on food systems, finding the right intermediate speeds up the journey from research idea to real-world impact on farms. I’ve seen how a single well-chosen building block in the lab ends up increasing yields on a hundred acres years later.
Materials scientists also look for ways to add fluorinated aromatics to their work, especially when engineering advanced polymers, liquid crystals, or specialty coatings. The precise placement of fluorine leads to changes in thermal or electrical properties, which feed back into performance in consumer and industrial products.
Plenty of pyridine derivatives crowd catalogs and supply lists. The real-world question: How do they actually perform? From experience, the trio of substituents on 2-Chloro-3-Methyl-5-fluoropyridine grants access to transformations that turn out tricky with simpler counterparts. If you try to substitute, say, 2-chloro-5-fluoropyridine, you'll notice the missing methyl often changes reactivity enough to stall or drop yields. Methyl groups modulate both steric and electronic effects, setting up the ring for specific attack points.
Fluorinated compounds come with a reputation for unpredictability in both safety and reactivity. This molecule strikes a balance: including only one fluorine keeps hazardous profiles in check but adds just enough effect for synthetic benefits. On stability, anecdotes from lab storage show this compound keeping its quality over time, which isn’t always the case for more reactive or volatile analogues.
No commentary about specialty chemicals can overlook trust. Consistency and transparency matter as much as technical specifications. Following E-E-A-T principles — experience, expertise, authoritativeness, and trustworthiness — is not just a Google guideline but also good sense in sourcing chemicals. Having worked in both academia and the chemical industry, I’ve seen too many projects ruined by irregular supply or mysterious batch-to-batch changes. Credible sourcing, clear certificates of analysis, and traceable origins for 2-Chloro-3-Methyl-5-fluoropyridine build a base for successful, safe work.
Direct experience in procurement shows that customers rarely forgive unreliable shipments. Social proof, word of mouth, and positive reviews about a specific pyridine’s grit and reliability can shape broader purchasing trends. I know of at least one case where a manufacturing plant canceled a large order with a supplier after three inconsistent shipments of the same labeled product. Return business is earned day by day; the responsible supplier of 2-Chloro-3-Methyl-5-fluoropyridine understands the stakes.
Of course, no chemical supply runs on autopilot. The challenge with compounds like this one is ensuring purity at scale while keeping costs reasonable for research and production. Purification can get tricky, especially with close-boiling isomers or unwanted byproducts that sneak in during manufacturing. Sourcing starting materials and controlling every process step in the synthesis are crucial to delivering on quality. Teams with deeper experience in pyridines typically optimize syntheses so that side reactions don’t swamp the main product, but they have to invest in skilled chemists and strong QC departments.
Sustainability is also becoming a bigger factor. My conversations with customers and peers make it clear that reducing waste and limiting hazardous byproducts matters more today than it did even five years ago. Suppliers that manage to cut out harmful reagents or develop more eco-friendly workups will stand out. In the chemical industry, incremental improvements — like shifting to greener solvents or updating purification — build up to major improvements across entire supply chains.
A smaller but growing concern: regulatory shifts. In the EU and many other places, fluorinated chemicals come under scrutiny for potential environmental persistence. Producers respond by offering detailed technical data and working transparently with customers and regulators. Being up-front about analytical results and environmental impact is key to building trust across the industry.
Improvement starts with strong feedback loops between end users, suppliers, and researchers. This has played out in my own collaborations. As synthetic teams switch to 2-Chloro-3-Methyl-5-fluoropyridine, they share reaction performance, impurity profiles, or stability after storage. An industry that actually listens adapts quickly — optimizing reaction conditions, packaging, or even labeling for smoother workflow integration.
Suppliers can do a lot by investing in analytical infrastructure and transparency. Providing full NMR spectra, impurity breakdowns, or shelf-life data as routine, instead of just on request, sets the standard for trustworthiness. Even simple moves, like labeling each lot with its production date and batch number, make a real operational difference. On the production side, switching to continuous flow or greener reaction conditions marks progress toward both efficiency and environmental stewardship.
Buyers and scientists should push for open channels to discuss performance and needs. I’ve seen emerging models where large pharmaceutical or materials companies work directly with suppliers to co-optimize formulations. By sharing more data and collaborative targets, both sides avoid unpleasant surprises in scale-up, regulatory filings, or real-world end uses.
Finally, the entire chain needs ongoing education and vigilance on best practices. Handling, storage, and disposal are not afterthoughts; they’re part of the process to keep people safe and avoid unnecessary issues down the line. Suppliers who offer useful handling guides, or who train users on-site, see lower incident rates and higher satisfaction.
Working in chemical development gives you a front row seat to both the promise and the pitfalls of fine chemicals. 2-Chloro-3-Methyl-5-fluoropyridine brings together features that answer real research and production needs. As drug molecules and specialty chemicals become more complex, starting materials like this pyridine let chemists innovate without having to build every structure from scratch. Better tools build a better world. Challenges remain in cost, sustainability, and regulatory compliance, but the push toward improvement runs strong across the industry.
Trust in high-quality, reliable intermediates supports breakthroughs in everything from medicine to agriculture to next-generation materials. In my years working with chemists — and actually using these molecules on the bench — the demand is always for products that work as promised, every time. 2-Chloro-3-Methyl-5-fluoropyridine won’t solve every problem by itself, but as part of a robust toolkit, it puts more possibilities within reach for builders and creators across science and industry.
