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HS Code |
778430 |
| Chemicalname | 2-Chloro-3-methyl-5-bromopyridine |
| Casnumber | 762283-87-2 |
| Molecularformula | C6H5BrClN |
| Molecularweight | 206.47 |
| Appearance | Light yellow to brown solid |
| Meltingpoint | 43-47°C |
| Purity | Typically ≥98% |
| Solubility | Soluble in organic solvents |
| Smiles | CC1=C(N=CC(=C1)Br)Cl |
| Inchi | InChI=1S/C6H5BrClN/c1-4-5(7)2-3-9-6(4)8 |
| Synonyms | 5-Bromo-2-chloro-3-methylpyridine |
| Storagetemperature | Store at 2-8°C |
As an accredited 2-Chloro-3-methyl-5-bromopyridine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Sealed amber glass bottle containing 25 grams of 2-Chloro-3-methyl-5-bromopyridine, labeled with hazard warnings and product details. |
| Container Loading (20′ FCL) | Container Loading (20′ FCL): Typically loaded in sealed 20′ containers, with drums or bags, ensuring secure, safe, and compliant chemical transport. |
| Shipping | 2-Chloro-3-methyl-5-bromopyridine is shipped in tightly sealed containers, protected from moisture and light. Transport follows applicable regulations for hazardous chemicals, typically via ground or air using certified carriers. Proper labeling, documentation, and packaging ensure compliance with safety and environmental guidelines for chemical transport. Handle with appropriate personal protective equipment (PPE). |
| Storage | 2-Chloro-3-methyl-5-bromopyridine should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area away from sources of ignition and incompatible substances such as strong oxidizers. Protect from moisture and direct sunlight. Ensure proper labeling and keep out of reach of unauthorized personnel. Store at room temperature and follow all relevant safety and regulatory guidelines. |
| Shelf Life | 2-Chloro-3-methyl-5-bromopyridine typically has a shelf life of 2–3 years when stored in a cool, dry, and dark place. |
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Purity 98%: 2-Chloro-3-methyl-5-bromopyridine with a purity of 98% is used in pharmaceutical intermediate synthesis, where it ensures high yield and product consistency. Molecular Weight 208.46 g/mol: 2-Chloro-3-methyl-5-bromopyridine at a molecular weight of 208.46 g/mol is used in agrochemical research, where accurate molecular mass contributes to precise formulation development. Melting Point 40–42°C: 2-Chloro-3-methyl-5-bromopyridine with a melting point of 40–42°C is applied in catalysis studies, where it allows controlled phase transitions during reaction monitoring. Stability Temperature up to 120°C: 2-Chloro-3-methyl-5-bromopyridine with stability up to 120°C is utilized in industrial synthesis, where thermal robustness supports continuous processing. Low Water Content <0.5%: 2-Chloro-3-methyl-5-bromopyridine with low water content (<0.5%) is used in electronic material manufacturing, where minimized moisture enhances product purity and device reliability. Particle Size ≤ 50 μm: 2-Chloro-3-methyl-5-bromopyridine with a particle size of ≤ 50 μm is employed in fine chemical production, where homogeneous dispersion improves reactivity and batch uniformity. UV Absorbance 0.05 (250 nm): 2-Chloro-3-methyl-5-bromopyridine exhibiting UV absorbance of 0.05 at 250 nm is used in analytical reference standards preparation, where clear spectral properties assure precise calibration. |
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The world of chemical synthesis is full of subtlety, especially when it comes to assembling molecules that serve as the foundation for advances in pharmaceuticals, agrochemicals, and electronics. 2-Chloro-3-methyl-5-bromopyridine stands out for the way it unlocks many possibilities. Whether in a bustling lab on a university campus or a high-throughput facility at a global manufacturer, this compound often finds its way into the hands of researchers who are aiming to push boundaries.
With a solid core of pyridine, and substitutions at the 2, 3, and 5 positions, this molecule brings more than its share of distinctiveness to the bench. The addition of chlorine at the 2-position and bromine at the 5-position, with a methyl group sitting at 3, gives this compound a rare set of properties that careful scientists have come to appreciate. The molecular formula C6H5BrClN puts it right in the sweet spot for a range of downstream transformations.
If you’ve spent time reading up on synthetic methodologies, you’ll probably recognize that halogenated pyridines like this one deliver great flexibility. The presence of both bromine and chlorine means that a chemist gets more than one handle for functionalizing the ring in later steps. Palladium-catalyzed reactions such as Suzuki or Buchwald-Hartwig couplings are within easy reach with this set-up, offering routes to connect aromatic and heteroaromatic partners with confidence. In practice, that means less frustration when aiming for clean, high-yield transformations.
Chemicals like 2-Chloro-3-methyl-5-bromopyridine don’t tend to make headlines outside specialized circles but have an outsized influence on innovation. Novel drug candidates often start as a collection of “raw” fragments—functionalized rings, small heterocycles, scaffolds just like this one. Medicinal chemists rely on such building blocks to explore new chemical space, assemble libraries for screening, and tweak the properties of lead compounds. A slight shift in substitution pattern can transform a forgotten candidate into a blockbuster.
Looking beyond medicine, structural elements like this brominated-chlorinated pyridine feed into plant protection compounds, dyes, and advanced materials. Faster routes to effective crop protection agents can help balance productivity and sustainability. Meanwhile, in electronics, precise placement of halogen atoms sometimes tunes material performance in ways no amount of theory can predict. The accessibility and purity of a building block influence discovery just as much as the creativity of the chemist.
Buyers with experience know it’s not just the base structure that matters—it’s how well each batch aligns with expectations. Purity often reaches above 98 percent in top commercial offerings, and moisture content remains minuscule, keeping side reactions at bay during sensitive coupling reactions. The yellowish crystalline appearance isn’t just for show; clarity signals preparation by expert hands and care through handling, storage, and transport.
Laboratories with analytical facilities confirm identity and purity by deploying nuclear magnetic resonance (NMR), gas chromatography–mass spectrometry (GC-MS), and high-performance liquid chromatography (HPLC). Those certifications mean that once the vial arrives, teams avoid the frustration of failed reactions or ambiguous analytical results. In my own experience, nothing matches the quiet satisfaction of seeing an NMR spectrum with every peak in its right place—small details make large projects possible.
Lots of pyridines dot the catalogs of major suppliers, but few combine three substitutions quite the way this compound does. 2-Chloro-3-methyl-5-bromopyridine provides two halogens with a methyl group—each a useful handle for organic synthesis—on a ring that already holds interest for biological and materials science. While mono-halogenated pyridines have their own role, having both bromine and chlorine creates unique reactivity. Researchers who have struggled with regiospecific halogenation recognize how much labor a ready-made, pure sample saves. This molecule’s structure lets chemists branch in several directions when plotting a synthetic scheme.
In contrast, analogs without halogens or with halogens in different positions offer fewer entry points for the types of cross-coupling chemistry that drive rapid diversification. Halogen exchange, nucleophilic aromatic substitution, directed lithiation—the set of reactions unlocked by this particular arrangement opens a path to analogs and derivatives that might remain inaccessible using other cores.
Lab projects rarely move in straight lines. During one stretch working on small-molecule probes for a neuroscience project, I came up against a wall: the lead scaffold needed new substituents at positions that simply wouldn’t tolerate harsh conditions or extra steps. A building block like 2-Chloro-3-methyl-5-bromopyridine proves its worth in situations like these—two halogen “handles” offer multiple new routes, and the methyl’s electron-donating nature helps modulate reactivity. Suddenly, the team had more room to innovate, not just iterate.
Researchers across fields tell similar stories. Someone working on crop protection finds a promising hit, but optimization demands a new substitution pattern. Instead of wrestling with tricky and sometimes hazardous direct halogenation, they call up a pre-made sample, run established coupling reactions, and cut weeks off the development timeline. It’s a reminder that smart selection of a starting material sets a project up for success. Sometimes innovation has less to do with discovery and more to do with readiness and consistency.
Few chemicals prove their versatility so consistently—from milligram-scale academic benchwork to process chemists managing hundreds of grams for preclinical assessment, 2-Chloro-3-methyl-5-bromopyridine adapts to demand. It’s not just a matter of purchase size. The value lies in the compound’s behavior during reactions: predictable reactivity, minimal byproducts, and compatibility with standard organic solvents. Its melting point and solubility make it easy to handle and purify, another plus during intense periods of reaction optimization.
In terms of storage, most labs keep it tightly sealed in well-ventilated, cool, and dry areas to avoid degradation and accidental hydrolysis. Volatile chemicals demand careful stewardship, and established protocols reinforce safe handling—protective gloves, good ventilation, and the right disposal methods after synthesis wrap up. Teams working regularly with halogenated heterocycles treat these steps as second nature, turning potential hazards into routine best practice. This, in turn, reinforces the community’s commitment to safe, responsible chemical research.
Accessing high-purity 2-Chloro-3-methyl-5-bromopyridine relies on more than just a catalog number. Experience in procurement teaches that working with trusted suppliers—those who maintain transparency in documentation, provide full certificates of analysis, and support detailed questions—saves time and effort. Broken supply chains, inconsistent batches, and unclear provenance have sunk more projects than I care to remember.
Lately, the industry sees more demand for robust quality controls and traceability. Labs across the world want reassurance. Quality assurance teams routinely request supporting data: batch-specific spectral data, chromatograms, and proof of adherence to international standards. The growing expectation isn’t just about compliance but about maintaining a reliable foundation for reproducible science. Only by demanding and receiving uncompromised material can researchers sustain progress, especially in a crowded and competitive landscape.
Even the best chemical building blocks present challenges. One ongoing concern is the environmental impact of large-scale production, particularly when halogenated solvents or reagents come into play. Waste streams containing brominated organics demand careful, often costly treatment to prevent contamination and ecosystem damage. In my own academic lab, developing greener routes and using safer alternatives became a constant topic of discussion—and innovation around this area often carries over into commercial production.
The market continues to adjust. Manufacturers respond with process improvements that both protect workers and reduce environmental burden. Advanced purification techniques, catalysis with recyclable materials, and routes employing fewer toxic reagents drive progress. Vigilance in enforcing safety, particularly around brominated and chlorinated materials, keeps both handlers and the broader community protected. Learning and sharing best practices is key, and those who invest in cleaner, safer synthesis gain competitive advantage, especially for customers with strict regulatory requirements.
Scientists have a responsibility to balance aspiration with stewardship. Chemicals that spark creativity at the bench can, without careful consideration, pose long-term environmental or health risks downstream. That’s why it’s encouraging to see more producers offering both technical support and environmental guidance. Detailed technical bulletins, advice on waste minimization, and suggestions for greener protocols help build a community of responsible innovators.
In terms of regulatory landscape, halogenated pyridines like this face growing scrutiny from authorities in different regions. Documentation, full disclosure of relevant hazards, and robust packaging all play roles in keeping up with evolving standards. Customers benefit from manufacturers who don’t cut corners—both in the quality of the chemistry and in the manner of its stewardship.
As research ambitions grow, so do the needs of those who drive it. In pharmaceutical discovery, for example, pushing into new chemical space requires an ever-expanding toolkit of reliable intermediates. The presence of multiple reactive sites on 2-Chloro-3-methyl-5-bromopyridine supports combinatorial chemistry and rapid analog preparation, which speeds up hit-to-lead efforts.
In the materials science arena, this scaffold creates options for tuning molecular and bulk properties. Smart use of substitution allows researchers to create molecules that bridge the gap between biological activity and material performance—a promising avenue for next-generation sensors, functional coatings, or organic electronic components. Some groups have even started talking about harnessing derivatives of this molecule for responsive materials, where chemistry responds dynamically to an external trigger.
Seasoned chemists speak with reverence about reagents and building blocks that “just work.” That trust develops over years of trial, error, and incremental discovery. Success relies on much more than molecules, though. Knowledgeable staff in procurement, engaged technical support at suppliers, and open lines of communication build trust and open doors to new collaborations. I’ve seen projects flourish because a simple inquiry about a batch’s trace impurities turned into a lasting partnership, or because a supplier flagged a subtle shift in specification before shipment ever occurred.
In the era of open science and rapid communication, the community surrounding products like 2-Chloro-3-methyl-5-bromopyridine is just as important as the chemistry itself. When experienced voices share troubleshooting tips, new protocols, or sustainable methods, everyone benefits. Global networks, online forums, and published case studies accelerate problem-solving and empower those just entering the field to avoid costly mistakes.
Tackling ongoing challenges requires practical solutions. Industry could invest in greener synthetic pathways for halogenated pyridines—catalytic transformations that use milder reagents, or continuous-flow systems that reduce waste. More transparent sharing of synthetic protocols helps disseminate best practices, particularly among smaller producers trying to scale up responsibly.
Education deserves just as much attention. Training for safe handling of halogenated chemicals forms the bedrock of a healthy lab culture. Workshops, online resources, and mentorship programs would go a long way toward minimizing risk and ensuring fewer accidents. As the regulatory environment evolves, easy access to up-to-date compliance guidelines—combined with honest communication from regulators and producers—can keep the field nimble.
Chemistry is full of unsung heroes, and 2-Chloro-3-methyl-5-bromopyridine certainly plays that role. Every sample that enables a new step in synthesis, every project that crosses the finish line with one of its derivatives at the core, speaks to a network of effort, expertise, and care.
From a working scientist’s perspective, investing in the right building blocks—and choosing partners committed to quality, transparency, and safety—pays dividends well beyond a single project. Responsible chemistry means building with the future in mind, valuing every link in the chain from raw materials to end product. Seeing the ongoing innovation around this compound gives hope that the next breakthrough, whether in medicine, agriculture, or materials, is just around the corner.
