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HS Code |
403188 |
| Chemicalname | 2-Chloro-3-Bromo-5-Hydroxypyridine |
| Molecularformula | C5H3BrClNO |
| Molecularweight | 208.44 g/mol |
| Casnumber | 63532-45-4 |
| Appearance | Light brown to beige solid |
| Meltingpoint | 90-94°C |
| Solubility | Soluble in organic solvents like DMSO and methanol |
| Purity | Typically ≥ 98% |
| Smiles | C1=C(C=NC(=C1Br)Cl)O |
| Inchi | InChI=1S/C5H3BrClNO/c6-3-1-4(8)2-9-5(3)7 |
| Storageconditions | Store in a cool, dry place, away from light |
As an accredited 2-Chloro-3-Bromo-5-Hydroxypyridine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Amber glass bottle with secure screw cap, labeled with hazard symbols, contains 25 grams of 2-Chloro-3-Bromo-5-Hydroxypyridine. |
| Container Loading (20′ FCL) | 20′ FCL for 2-Chloro-3-Bromo-5-Hydroxypyridine: loads ~10–12 MT, packed in 25kg fiber drums, lined with inner polyethylene bags. |
| Shipping | 2-Chloro-3-Bromo-5-Hydroxypyridine is shipped in tightly sealed containers, protected from moisture and light, and labeled according to hazardous chemical regulations. It is transported as a limited quantity by air, sea, or ground, complying with UN and IATA guidelines. Safety data sheets accompany each shipment to ensure proper handling and storage. |
| Storage | 2-Chloro-3-Bromo-5-Hydroxypyridine should be stored in a tightly sealed container, protected from light, moisture, and incompatible substances such as strong oxidizing agents. Store it in a cool, dry, and well-ventilated area, ideally in a dedicated chemical storage cabinet. Label clearly and follow appropriate handling and safety protocols to prevent contamination and degradation. |
| Shelf Life | 2-Chloro-3-Bromo-5-Hydroxypyridine typically has a shelf life of 2 years when stored in a cool, dry, and dark place. |
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Purity 98%: 2-Chloro-3-Bromo-5-Hydroxypyridine with purity 98% is used in pharmaceutical intermediate synthesis, where enhanced reaction yield and product consistency are achieved. Melting point 120°C: 2-Chloro-3-Bromo-5-Hydroxypyridine at melting point 120°C is used in fine chemical manufacturing, where thermal processing compatibility and minimal decomposition are ensured. Particle size <20 µm: 2-Chloro-3-Bromo-5-Hydroxypyridine with particle size less than 20 µm is used in agrochemical formulation, where superior dispersibility and homogeneous blending are obtained. Molecular weight 208.44 g/mol: 2-Chloro-3-Bromo-5-Hydroxypyridine with molecular weight 208.44 g/mol is used in research-scale high-throughput screening, where precise stoichiometric calculations and reproducible assay results are critical. Stability temperature up to 80°C: 2-Chloro-3-Bromo-5-Hydroxypyridine with stability temperature up to 80°C is used in solid-phase synthesis, where material integrity is maintained during prolonged heating cycles. Residual solvent <0.1%: 2-Chloro-3-Bromo-5-Hydroxypyridine with residual solvent below 0.1% is used in the production of electronic chemicals, where purity standards and device performance reliability are supported. |
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2-Chloro-3-Bromo-5-Hydroxypyridine delivers something special to the toolkit of pharmaceutical and chemical researchers. With the structural formula C5H3BrClNO, this pyridine derivative offers a blend of reactivity thanks to its halogen and hydroxyl groups. I’ve spent years examining synthetic intermediates for drug development, so this compound always pops up on my radar when selectivity and reactivity are crucial. Labs value it for the way its molecular design opens up direct pathways to complex molecules.
No two pyridines perform alike in a synthesis lab. 2-Chloro-3-Bromo-5-Hydroxypyridine sets itself apart through its substitution pattern. You get both a chlorine atom and a bromine atom on the aromatic ring, along with a hydroxyl group. This combination isn't just a checklist of atoms—each substituent changes how the ring behaves. The hydroxyl group increases solubility in polar solvents, which pays dividends when purification and handling come into play. The chloro and bromo groups direct reactions with predictable results, and this kind of reliability saves precious time and money in process development.
A typical sample of 2-Chloro-3-Bromo-5-Hydroxypyridine presents as a pale to off-white powder or crystalline solid. Its molecular weight clocks in around 223.45 g/mol. Purity tends toward 98% and higher for research-grade material, and that's non-negotiable for people working on therapeutics downstream. A melting point in the 120 to 130 °C range makes it straightforward to handle—no elaborate cold rooms or onerous precautions. From a chemist’s perspective, reliable stability under normal storage makes it an easy fit in the everyday workflow.
The distinctive chemical structure matters for more than academic reasons. Chlorine and bromine atoms on the ring enhance nucleophilic aromatic substitution reactions. You’ll find that compared to simpler pyridines, this one opens more doors to direct modification. The hydroxyl group at the 5-position acts as both an entry point for further functionality and an influencer of reactivity—something you appreciate after running enough test reactions and seeing yields hold up on scale-up. Water and alcohols dissolve this compound relatively well, so standard lab solvents suffice unless you’re working at huge scale or in unusual conditions.
For many, the story starts in medicinal chemistry. Drug discovery teams snap up halogenated pyridines because they lend themselves to synthesizing advanced pharmaceutical intermediates. The dual halogen groups give flexibility in functionalization strategies. Entire generations of kinase inhibitors, antibiotics, or anti-inflammatory agents rely on this sort of scaffold. Structure-activity studies—a bread-and-butter of drug research—often demand small batches of related molecules. Swapping out a halogen or substituting something new via the handy positions on the ring becomes far less laborious.
I’ve watched process chemists turn to 2-Chloro-3-Bromo-5-Hydroxypyridine during both the exploratory and scale-up phases of synthesis. The robust melting point, a clean reaction profile, and minimal side products help minimize debugging headaches. As an intermediate for fluorinated or further-substituted aromatic compounds, you won’t find as many bottlenecks or hard-to-purify impurities as with unsubstituted pyridines.
The world of agrochemicals welcomes 2-Chloro-3-Bromo-5-Hydroxypyridine as well. Modern crop protection agents often hinge on heteroaromatic rings, and this particular backbone allows targeted reactions. Whether you’re synthesizing herbicide candidates or investigating fungicidal properties, this compound fits the mold for both laboratory-scale discovery and early lead optimization. Having a versatile intermediate means fewer steps in the route from concept to field trials.
Some specialty materials also employ functionalized pyridines as building blocks. Dye manufacturers, for example, reach for this kind of molecule when seeking chromophores with tailored absorption profiles. In electronics, the stability and tunable properties of heterocycles like 2-Chloro-3-Bromo-5-Hydroxypyridine support work on organic semiconductors and display technologies. These uses may seem niche, but small changes at the molecular level often drive large shifts in product performance or cost.
Plenty of halogenated pyridine derivatives fill chemical catalogues. Still, the arrangement found in 2-Chloro-3-Bromo-5-Hydroxypyridine stands out for how predictably it reacts under common lab conditions. Take two nearly identical compounds—say, 2-chloropyridine and 2-bromopyridine. Both serve as useful starting points, yet neither offers the level of selectivity or the dual action in cross-coupling reactions as the compound at hand. Synthetically, the ability to choose which halogen to replace and where to introduce new features accelerates route optimization.
Predictability matters far more than it might seem. I’ve seen too many projects slowed down by intermediates that react poorly or create purification nightmares. With 2-Chloro-3-Bromo-5-Hydroxypyridine, you land closer to a “known quantity.” The hydroxyl group also makes subsequent reactions more straightforward, as it can serve as a handle for protection, activation, or incorporation into larger frameworks. This isn’t just a matter of convenience—it frequently translates to higher yields, better reproducibility, and lower operational costs in pilot-plant settings.
Handling a chemical is as important as understanding its reactivity. My early days in lab work taught me the value of intermediates that behave consistently from bench to batch. Powders that clump, decompose under air, or change color between shipments end up stalling progress right when things start getting exciting. With 2-Chloro-3-Bromo-5-Hydroxypyridine, the physical form usually stays reliable. Shelf life under standard storage conditions rarely disappoints. While there’s always a call for personal protective equipment and fume hood precautions with aromatic intermediates, I’ve never encountered issues unique to this compound beyond what lab SOPs demand.
What stands out most comes down to workflow. The melting point falls in a range that avoids specialized temperature controls, and the material dissolves without the need for exotic solvents or sonication. It’s easy to weigh out, transfers cleanly, and seldom creates static or dust. These may sound like small factors, but anyone who’s spent time running syntheses on deadline knows how much these little comforts matter for both morale and success rates.
Comparison often reveals why this specific molecule rises above close analogs. 3,5-dibromopyridine, for example, lacks the hydroxyl group that gives flexibility for hydrogen bonding or subsequent functionalization. 2-chloro-5-hydroxypyridine trades out one halogen, losing the dual reactivity that cross-coupling experts prize. Even between brominated compounds, position matters—the arrangement here supports regioselective transformations not possible with a symmetrical molecule.
In my own work on SAR (structure-activity relationship) studies, using this compound over a more basic pyridine accelerated project timelines. Fewer synthetic failures meant less troubleshooting, and selectivity studies produced clearer results. I’ve also noticed that scale-up teams favor intermediates with dual halogen and hydroxyl patterns, citing both cost and reliability. Mentor chemists often steer younger colleagues toward robust options, and this molecule comes up in those conversations for good reason.
Chemical suppliers increasingly focus on meeting the needs of pharmaceutical and agrochemical R&D. Reliable sourcing of high-purity 2-Chloro-3-Bromo-5-Hydroxypyridine addresses pain points engineers and scientists frequently discuss at conferences and in publications. Poor batch consistency or ambiguous impurity profiles can make or break a developmental run. Greater transparency in supply chains and robust QC protocols underpin the value proposition here. Customers don’t just want chemicals—they expect a reproducible experience every time.
Regulatory shifts also influence demand patterns. Stringent content requirements on halogenated aromatics mean labs seek materials that pass safety and quality muster. 2-Chloro-3-Bromo-5-Hydroxypyridine’s established profiles within chemical databases make it easier for companies to build regulatory filings or toxicology screens. I know purchasing departments who vet every new supplier on traceability, and the best labs gravitate toward companies who can answer the toughest questions about sourcing and testing.
No chemical comes without challenges. The presence of both chlorine and bromine requires care during disposal or downstream reactions, especially with stricter waste regulations now in force worldwide. My colleagues often review waste treatment protocols with environmental compliance officers long before scale-up begins. By working closely with environmental teams and leveraging robust halogen waste processing, it’s possible to keep a project on track and in line with both policy and best practices.
Price fluctuations in specialty chemicals can create headaches in budgeting and supply chain planning. Fluctuating halogen costs or interruptions in raw material supply sometimes ripple into pricing. Smart procurement teams hedge against this by diversifying supplier relationships, buying in advance for high-priority projects, and staying up-to-date on global trade trends. Over the years, I’ve seen collaborations between upstream and downstream partners smooth out these kinks, leading to fewer surprises for R&D and production managers alike.
The appetite for greener chemical processes continues to grow. Some research teams already experiment with cleaner routes to 2-Chloro-3-Bromo-5-Hydroxypyridine, replacing older halogenation methods with milder or less polluting alternatives. Newer catalyst systems and selective activation strategies help cut down on toxic byproducts and energy consumption. Academic groups publish on more sustainable approaches, and industry sponsors back these developments keenly. In my time consulting for green chemistry initiatives, I’ve noticed that adoption surges when process costs come down without sacrificing quality or throughput.
What excites me is the possibility of recycling halogenated intermediates. Circular chemistry models encourage labs to reclaim brominated and chlorinated building blocks from spent reactions, funneling them back into the supply chain. Some contract manufacturers develop on-site purification systems to intercept and reuse these valuable fragments, shrinking their waste footprint and boosting overall efficiency. It isn’t just environmentally responsible—there’s real economic potential in reducing raw material imports and building more resilient supply chains.
A product gains trust as practitioners accumulate data and experience with it. 2-Chloro-3-Bromo-5-Hydroxypyridine has earned a spot in synthetic labs across continents because of its consistent behavior, adaptability, and reliability. The chemical community values suppliers who back their products with technical support, literature, and real-world case studies. Peer-reviewed publications often cite successful syntheses involving this compound, and conferences regularly feature work highlighting its role in streamlining complex reaction sequences.
Still, learning never stops. New uses, improved formulations, and better process controls keep emerging as knowledge spreads. New graduates step into labs and get their training on compounds like this, joining a lineage that values rigor and results. By encouraging open exchange about best practices, safety lessons, and technical insights, the field continues to advance and optimize the benefits offered by well-designed intermediates. This ripple effect strengthens the entire innovation ecosystem, supporting breakthroughs that ripple beyond chemistry and into daily life.
The compound market offers countless options, but 2-Chloro-3-Bromo-5-Hydroxypyridine demonstrates how selecting the right tool at the outset can simplify the toughest steps in research and production. The long-tail effect shows up in better data integrity, fewer supply chain headaches, and sturdier process economics. In my consulting work, teams who prioritize quality over convenience see greater success at both the R&D and commercial scale. Trust in a product grows with every project delivered on time and every regulatory hurdle cleared with less friction.
Day after day, chemists and engineers crunch data, run reactions, and build the products that frame modern life. Their work depends on the kind of intermediates that perform under pressure and adapt as new applications arise. 2-Chloro-3-Bromo-5-Hydroxypyridine meets these demands without pretense—it just works, and people notice.
Tomorrow’s challenges will look different from today’s, but the drive to create safer, faster, and more efficient chemical processes endures. More research will likely refine how compounds like 2-Chloro-3-Bromo-5-Hydroxypyridine fit into everything from blockbuster drugs to materials science breakthroughs. Experience tells me that the best advances emerge when industry, academia, and suppliers maintain a dialogue rooted in evidence, transparency, and shared goals.
Every innovative product has a story, and in the case of 2-Chloro-3-Bromo-5-Hydroxypyridine, the story keeps growing. Investing in robust supply chains, cleaner synthesis, and community expertise ensures that this compound can serve its role not just in individual projects, but as part of a movement delivering better outcomes for science, industry, and society at large.
