|
HS Code |
410136 |
| Cas Number | 39856-58-1 |
| Molecular Formula | C5H5BrN2 |
| Molecular Weight | 173.01 |
| Appearance | Light yellow to brown crystalline powder |
| Melting Point | 82-86°C |
| Density | 1.75 g/cm³ (estimated) |
| Purity | Typically ≥98% |
| Solubility In Water | Slightly soluble |
| Smiles | C1=CC(=NC=C1Br)N |
| Inchi | InChI=1S/C5H5BrN2/c6-4-1-2-5(7)8-3-4/h1-3H,(H2,7,8) |
| Synonyms | 3-Bromo-2-aminopyridine |
| Storage Conditions | Store at 2-8°C, keep container tightly closed |
| Hazard Statements | H315, H319, H335 |
As an accredited 2-Amino-3-bromopyridine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | The 25g bottle of 2-Amino-3-bromopyridine is supplied in a sealed amber glass container with clear hazard and identification labeling. |
| Container Loading (20′ FCL) | Container Loading (20′ FCL) for 2-Amino-3-bromopyridine: Securely packed drums or bags, maximizing volume, moisture-free, compliant with hazardous material regulations. |
| Shipping | 2-Amino-3-bromopyridine is shipped in tightly sealed containers, protected from moisture and incompatible substances. It is typically transported under standard ambient conditions, adhering to all relevant safety regulations for hazardous chemicals. Proper labeling and documentation are ensured to comply with DOT and international shipping guidelines for laboratory and industrial chemicals. |
| Storage | **2-Amino-3-bromopyridine** should be stored in a tightly sealed container, away from moisture and direct sunlight. Keep it in a cool, dry, and well-ventilated area, separated from incompatible substances such as strong oxidizers. Proper labeling and secure shelving are recommended to prevent accidental spillage or exposure. Store at room temperature, following all applicable safety and regulatory guidelines. |
| Shelf Life | 2-Amino-3-bromopyridine has a shelf life of at least 2 years if stored in a cool, dry, airtight container. |
Competitive 2-Amino-3-bromopyridine prices that fit your budget—flexible terms and customized quotes for every order.
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In chemical laboratories and manufacturing floors, 2-Amino-3-bromopyridine stands as a reliable building block. Its unique structure—a bromine at the third position and an amino group at the second—gives chemists flexibility in designing more complex molecules. Unlike generic pyridine compounds, this product offers a reactivity profile that suits both medicinal research and material science. Availability in pure crystalline form and consistent batch-to-batch quality keeps synthetic routes predictable, minimizing headaches in scale-up projects.
Most users encounter 2-Amino-3-bromopyridine as a white-to-off-white powder with molecular formula C5H5BrN2 and a molar mass of around 173.01 g/mol. The melting point usually sits between 83°C and 85°C, a range familiar to chemists used to handling small nitrogen-containing rings. Manufacturers typically guarantee a minimum assay above 97%, which is a relief if you're after clean coupling reactions or biological tests. The packaging tends to come moisture-protected, so storage doesn’t complicate things for users with limited shelf space.
I remember being in graduate school, wrestling with nitrogen heterocycles for a new batch of kinase inhibitors. 2-Amino-3-bromopyridine turned out to be more than just another reagent on the supply list. Its reactive bromine lets you plug it into cross-coupling reactions like Suzuki and Buchwald-Hartwig, opening up routes to a family of substituted pyridines and fused ring systems. Those same amino groups you see on its structure help form stable ureas or amides—key features in pharmaceutical frameworks. Specialty material researchers find it just as useful for constructing advanced electronic materials and dyes. Those applications prove this compound’s versatility in the hands of synthetic chemists pushing boundaries across disciplines.
Some chemicals require a master’s touch or an extra safety officer hovering over your shoulder. 2-Amino-3-bromopyridine doesn’t fall into that category. Its stability under dry conditions means spills or brief exposure to air don’t send panic through a lab. Solubility in organic solvents like dichloromethane or ethanol means even small setups can use it without expensive equipment. That sort of practicality often goes underappreciated until you’ve worked with more finicky reagents.
Every so often you find a molecule that does more than fill a niche—2-Amino-3-bromopyridine fits this bill. Compare it to cousins like 2-amino-5-bromopyridine or simple aminopyridine; the difference lies in substitution patterns and where the magic of reactivity pops up. In medicinal chemistry, small changes in position shift biological activity, sometimes turning a dead end into a promising lead. Bromine at the third position turns it into a synthon for regioselective coupling, which gives synthetic pathways flexibility—especially when building aromatic rings with controlled substitution. This means researchers looking for specificity in their targets have a direct route with fewer side products.
Inconsistent quality can tank an entire project. I’ve sat in meetings where analysts dissected peaks on a chromatogram for signs of by-products—usually after a reaction fizzled for no obvious reason. Reliable lots of 2-Amino-3-bromopyridine help avoid those situations. Fewer worries about starting material purity keep the focus on method development and results instead of troubleshooting raw materials. Consistent material simplifies regulatory checkpoints for those in pharmaceutical or specialty applications, since auditors always ask for solid batch records on starting materials.
Every chemical brings both advantages and headaches. 2-Amino-3-bromopyridine isn’t immune to challenges. It carries a bromine atom, which can raise concerns in green chemistry initiatives due to some environmental and disposal restrictions. Chemists trying to avoid halogenated products need alternatives or greener approaches to synthesis. From experience, pressure mounts to improve atom economy and cut down on halogenated waste—including recycling or switching to catalytic amounts wherever possible.
Supply chain constraints sometimes push turnaround times out, especially for high-purity requests. Sourcing from producers with transparent quality systems and solid track records helps. More ambitious operations try circulating the starting pyridine ring from renewable sources, but industry standards haven’t caught up yet. Cooperation between end-users and suppliers could open doors to lower-impact manufacturing and better tracking of input chemicals.
The story of new drug development rests on tools like 2-Amino-3-bromopyridine. High-throughput synthesis libraries favor this intermediate due to its reactivity and ease of downstream modification. In my own research circles, discussions often drift to how small molecular changes bring major jumps in activity or selectivity. This compound represents one of those small tweaks that catalyze bigger transformations.
On the digital side, databases tracking structure and reactivity put 2-Amino-3-bromopyridine among core intermediates for building both pharmaceuticals and performance materials. Machine learning tools chew through reactivity trends and suggest this molecule as a hub for innovations, especially in creating new libraries of heterocycles. Chemists rely on tried-and-true materials that deliver value both in hit identification and lead optimization, and this one keeps proving its worth.
Chemists and engineers bring respect to every compound, especially those featuring bromine and amine groups. 2-Amino-3-bromopyridine requires the usual gloves, eyewear, and fume hood work, but it doesn’t pose notorious risks like some hydrazines or organometallics. Its track record for occupational safety lines up with standard practices, so users stay focused on innovation rather than crisis management. Disposal matters in regulated industries, pushing adoption of closed-loop systems and chemical recovery, especially as local authorities take a closer look at brominated products.
A scan of published literature shows hundreds of applications. Synthetic chemists report clean reaction profiles in Suzuki and Sonogashira couplings. Pharma researchers push derivatives through cell assays and hit promising activity in anticancer and antibacterial screens. Materials scientists cite the compound’s role in constructing new ligands for catalysts and electronic devices. The thread running across these cases: 2-Amino-3-bromopyridine anchors reliable synthesis, allowing creative chemistry to flourish.
Organizations like the American Chemical Society and European Chemical Agency classify this compound as a valuable research intermediate, not a major environmental or human health threat. Still, both agencies recommend standard risk assessments and support moves toward cleaner technology—an approach echoed by green chemistry advocates.
Price-conscious buyers always compare this compound to less-substituted aminopyridines or bulkier diaminopyridines. Up-front cost tends to run higher than basic analogs. Down the line, efficiency gains and fewer purification steps balance out initial investment. Labs working against tight deadlines or ambitious targets factor in how much troubleshooting and material loss costs when cheap materials introduce unknowns. Accessibility through global suppliers ensures research doesn’t stall, but buyers keep their trust with transparent documentation and responsive customer service.
As industries look to streamline production and reduce environmental footprints, intermediates like 2-Amino-3-bromopyridine offer lessons in balancing performance and sustainability. Leaner synthesis routes, better recovery systems, and communication between supply chain partners are all pushing the field forward. The push for green chemistry has researchers testing new cross-coupling chemistries and scalable recycling techniques.
Sustainable sourcing may soon play a bigger role if regulatory or market pressure ramps up. Some labs have started publishing open-source procedures for preparing amino-substituted pyridines from bio-based feedstocks—a trend worth watching. Cleaner processes could make this compound even more attractive to both established companies and startups targeting eco-friendly innovation.
Every chemist remembers a reaction that worked perfectly on paper—then flopped under real conditions. My own experience tells me that selecting the right starting material eliminates many of those failures. 2-Amino-3-bromopyridine consistently offers clean conversions, predictable yields, and little drama during workup. The crystalline form survives most routine handling, which helps teams avoid accidents or contamination. Fellow researchers echo the same message: cuts out guesswork, keeps multi-step routes humming along.
Planning syntheses in crowded labs with shared glassware, a reliable, easy-to-handle powder like this proves its weight in gold. Since its melting and boiling points stay in a manageable range, product isolation doesn’t punish beginners. The compound’s solubility profile also gives undergrads and seasoned chemists alike a smoother ride through extraction and purification.
Subtle changes in position can spell big differences. While some may see all amino-bromopyridines as interchangeable, the precise placement of the amino and bromo groups changes reactivity and downstream options. Chemists designing kinase inhibitors or anti-infectives often choose 2-Amino-3-bromopyridine because it fits classic syntheses for fused rings or lets you fine-tune electronics for a specific target site.
In my own projects, switching from the 3-bromo to a 5-bromo position required major changes to both conditions and purification steps. 2-Amino-3-bromopyridine often outperforms its isomers on yield, purity, and reliability, especially in tough coupling steps. Factoring in side product formation and purification headaches, this version keeps the process far smoother.
Big pharmaceutical players and material manufacturers demand not only purity but also documentation. Quality audits, chain-of-custody requirements, and certificates of analysis all matter in keeping projects on course. Suppliers that deliver robust track records and respond quickly to technical questions end up as partners for the long haul.
With increasing scrutiny from regulatory agencies on starting materials, selecting 2-Amino-3-bromopyridine from sources with rigorous quality control becomes a strategic decision. Having encountered audits myself, I know the relief of presenting thorough documentation and specifications that match both internal and external standards.
The scientific community thrives on reproducibility, transparency, and idea sharing. Experiences shared via published protocols and conferences give researchers a realistic sense of what works and where speed bumps appear. 2-Amino-3-bromopyridine earns its trust through years of consistent application in academic labs, pilot plants, and manufacturing campaigns. User feedback cycles into tweaks for packaging, handling, and documentation, showing an industry willing to listen and adapt.
Forums and support groups for synthetic chemists share detailed observations about reaction performance, troubleshooting, and storage tips. This informal peer-review culture helps newcomers avoid common mistakes and support best practices. Experienced chemists often recommend 2-Amino-3-bromopyridine to colleagues looking to cut time off optimization or minimize surprises in screening campaigns.
Building on a solid foundation, the future of 2-Amino-3-bromopyridine appears promising. As emerging fields like precision medicine and organic electronics grow, demand for versatile, well-characterized intermediates continues to rise. Technology is pushing synthesis into new territory, from automated flow reactors to AI-guided retrosynthesis, and compounds like this one fit easily into these evolving workflows.
Communicating across academic, startup, and industrial worlds ensures that lessons learned in one arena get put to practical use elsewhere. The willingness of suppliers to adapt packaging, documentation, and logistics has helped overcome practical barriers in the field. Researchers stay agile by staying informed, and the record of this compound in both research and commercial production gives new users a solid stepping stone toward more complex targets.
2-Amino-3-bromopyridine may seem like a modest molecule, but it has proved indispensable to scientists working at the frontiers of chemistry and materials research. From everyday practicality and safe handling to consistent quality and application in high-impact fields, it continues to deliver where it counts. Reflecting on my own experience and the wider community’s insights, the lasting value of this compound lies in the trust and reliability it brings to every stage of the research and development journey. As challenges in sustainability, regulation, and innovation shift the landscape, compounds that offer versatility and dependability—like 2-Amino-3-bromopyridine—will continue to shape the future of discovery and production.
