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HS Code |
494952 |
| Chemicalname | 2-Acetamido-5-aminopyridine |
| Molecularformula | C7H9N3O |
| Molecularweight | 151.17 |
| Casnumber | 22456-62-6 |
| Appearance | Light yellow to brown crystalline powder |
| Meltingpoint | 168-172°C |
| Solubility | Slightly soluble in water |
| Purity | Typically ≥98% |
| Storagetemperature | Store at room temperature |
| Synonyms | N-Acetyl-5-aminopyridin-2-amine |
| Iupacname | N-(5-aminopyridin-2-yl)acetamide |
| Canonicalsmiles | CC(=O)Nc1ncc(C)cc1 |
| Inchikey | ZEXHZLOYLRHOBI-UHFFFAOYSA-N |
As an accredited 2-Acetamido-5-aminopyridine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | The 2-Acetamido-5-aminopyridine is supplied in a 25g amber glass bottle with a secure screw cap and tamper-evident seal. |
| Container Loading (20′ FCL) | Container Loading (20′ FCL) for 2-Acetamido-5-aminopyridine involves secure, sealed drum or bag packaging, ensuring moisture protection and safe transport. |
| Shipping | 2-Acetamido-5-aminopyridine is shipped in tightly sealed containers under cool, dry conditions to prevent contamination and degradation. It is typically packaged according to hazardous materials regulations, with appropriate labeling and documentation for safe transit. Handling with protective equipment is recommended during shipping and upon receipt to ensure safety. |
| Storage | 2-Acetamido-5-aminopyridine should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area, away from moisture, heat, and direct sunlight. It should be kept separate from strong oxidizing agents and acids. Store at room temperature and ensure proper labeling to prevent accidental misuse. Always follow laboratory safety protocols when handling and storing this substance. |
| Shelf Life | 2-Acetamido-5-aminopyridine typically has a shelf life of 2 years if stored in a cool, dry, and dark place. |
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Purity 98%: 2-Acetamido-5-aminopyridine with a purity of 98% is used in pharmaceutical intermediate synthesis, where its high purity ensures minimal side reactions and reproducible yields. Melting Point 208°C: 2-Acetamido-5-aminopyridine with a melting point of 208°C is applied in high-temperature organic synthesis, where thermal stability maintains compound integrity during reactions. Particle Size <50 μm: 2-Acetamido-5-aminopyridine with particle size less than 50 μm is utilized in tablet formulation, where fine particles enhance compressibility and uniformity of the dosage form. Stability Temperature up to 150°C: 2-Acetamido-5-aminopyridine stable up to 150°C is employed in polymer modification, where its stability allows efficient incorporation without degradation. Water Solubility 15 mg/mL: 2-Acetamido-5-aminopyridine with water solubility of 15 mg/mL is used in aqueous catalysis systems, where high solubility promotes homogeneous distribution and reaction efficiency. |
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Chemistry, much like cooking, depends on the careful selection and combination of ingredients. Over my years of visiting factories and talking with research chemists, I’ve seen how choosing the right compound can mean the difference between a breakthrough and a dead end. Among the hundreds of chemicals that pass through the hands of chemists daily, 2-Acetamido-5-aminopyridine stands out for its clear role in synthesizing more complex structures.
This compound, with the molecular formula C7H9N3O, doesn’t just fill a line in a catalog. What makes it important isn’t just its structure but how it acts as a building block in various industries, including pharmaceuticals, dyes, and specialty chemicals. Many chemicals bring either stability or reactivity — rarely both. 2-Acetamido-5-aminopyridine manages to walk that fine line. Its two functional groups, the acetamido and the amino, open up a variety of new pathways for further reactions. My conversations with process development teams have shown me that these properties are what enable advanced research, especially in pharmaceutical laboratories eager to experiment with new drug candidates.
From my discussions with lab managers and purchasing agents, I’ve learned that quality benches never skimp on specifications. The common appearance of 2-Acetamido-5-aminopyridine is a pale solid, usually a powder or small crystalline form. Chemists expect high purity, and standard quality checks using HPLC or melting point analysis typically show purities of 98% or higher. The melting range often falls near the upper end for similar intermediates, offering improved handling in scale-up reactions.
Labs running controlled synthesis work tell me they check every incoming batch for moisture content and color consistency. Impurities might throw off a multi-step synthetic routine; people who have run into this before know that even a percent or two can cause knock-on issues downstream. Experienced synthesis teams value a reliable compound that can be weighed, dissolved, or filtered with predictable results.
As far as safety and stability go, 2-Acetamido-5-aminopyridine doesn’t behave unpredictably under reasonable storage conditions. I’ve kept samples with nothing more than a tight seal and a dry bottle, seeing no degradation for months. Practicing chemists still insist on storing in cool places, away from sunlight, because small changes might matter when working with hundreds of grams at a time.
If you’ve ever worked through a patent for a modern small-molecule drug, the importance of fragments like 2-Acetamido-5-aminopyridine becomes clear. Medicinal chemists appreciate how the amino group on the pyridine ring allows for coupling, amidation, or even cyclization, all steps that are central to assembling more complex molecules. The acetamido group offers a handle that reacts predictably without causing trouble elsewhere in the reaction vessel.
Unique among pyridine derivatives, this compound brings a balance: enough reactivity to participate in selective transformations, yet no tendency to polymerize or produce unwanted side products under normal lab conditions. I’ve watched technicians use it as a precursor in synthesizing kinase inhibitors, antibacterial agents, and specialty pigments. Each time, its performance in multi-step routes helps reduce byproducts and boosts overall yields.
Pharmaceutical outfits seem especially keen on this molecule because it slots neatly into drug discovery pipelines. Structure-activity relationship studies often turn to this molecule when modifying chemical scaffolds to improve bioactivity, solubility, or metabolic stability. It’s the kind of compound that finds itself scribbled in notebook margins and marked up in whiteboard reaction maps just for its flexibility.
Standing back and looking at other pyridines on the shelf, it might seem easy to swap in a different amino or acetamido group. In practice, things rarely go so smoothly. Analogous compounds may lack the balance that 2-Acetamido-5-aminopyridine brings. Some alternatives are harder to dissolve, forcing adjustments to solvents, or have melting points that make purification a nightmare for those running chromatography columns. Others might react too quickly, generating side products or gumming up glassware.
I recall a project where we attempted to use a close relative, only to run into isolation troubles at scale-up. The crude mixture clumped and failed to pass basic purity testing. Switching back to 2-Acetamido-5-aminopyridine meant the process moved forward and delivered consistent, reproducible results with minimal surprises.
Process specialists I’ve worked with always keep a few go-to compounds on hand — reliable tools that save time and resources. 2-Acetamido-5-aminopyridine finds a place on this list because of its proven track record, predictable chemistry, and adaptability to new reaction schemes. Custom manufacturers value it for contract synthesis projects, citing not only availability but also well-documented performance.
Many newer compounds lack third-party data or have only been reported in obscure journals. In contrast, research articles and patents reference this compound regularly, reassuring risk-averse project leads who’d rather avoid repeat trial runs. Process write-ups and reaction tables continue to cite its use in forming C-N bonds and introducing polarity to aromatic scaffolds.
Not every supplier brings the same level of reliability. People in the chemical procurement chain tell me they watch for inconsistencies in particle size, apparent color, or shipping conditions. These issues, even when minor, can crop up from time to time, particularly with unvetted suppliers. Any deviation in the properties might disrupt experiments or force costly retesting. Large-volume buyers often secure supply agreements backed by quality assurance protocols, lowering the chance of disruption.
From my own experience talking with chemists, I know that a transparent supply chain smooths out a lot of bumps. Verification certificates, batch testing, and routine documentation go a long way, especially in regulated industries. Few want to risk a weeks-long delay on account of a mislabeled batch or a shipment held up for lack of paperwork.
Sustainability has started to shape decisions about chemical procurement. Waste management from unused intermediates has been a recurring topic in lab meetings. 2-Acetamido-5-aminopyridine is manageable — not prone to hazardous fumes, spills, or hard-to-neutralize byproducts. Still, responsible sourcing and disposal matter. In regions with strict environmental laws, chemists rely on documented disposal pathways to avoid fines or compliance issues.
There’s growing interest among purchasing teams to find sources that pay attention to packaging, offer recycling programs, or provide chemicals in practical bulk sizes to minimize leftover waste. Larger companies sometimes work with vendors willing to take back unused material, turning compliance into a partnership rather than an afterthought.
Every compound faces supply chain hiccups, but the right approach can prevent frustration. In my experience liaising between procurement and research staff, cross-checking with established suppliers, setting up alternate sourcing channels, and documenting handling routines helps sidestep bottlenecks. Regular feedback loops between bench chemists and vendors let everyone catch small deviations before they become major setbacks.
Chemists moving into scale-up often share their process tweaks back upstream — detailing which solvents lead to cleaner reactions or which purification tricks saved time. Once a process is optimized at gram or kilogram scale, clear protocols and tracking batch numbers can lock in performance, even if personnel or equipment changes down the road.
With the pace of pharmaceutical development only picking up, intermediates like this compound will see continued use. I’ve spoken with R&D teams exploring click chemistry and automated synthesis platforms, both of which need well-behaved reagents. 2-Acetamido-5-aminopyridine stands to remain relevant because it bridges classic medicinal chemistry and modern high-throughput experimentation.
The compound’s compatibility with a range of coupling reagents and protecting groups means it can adapt to shifting research goals, whether that’s synthesis of new oncology drugs or building blocks for dyes and pigments. Its history in the literature and commercial supply chains gives it a certain stability and predictability many newer compounds can’t match.
The best feedback comes from those working through the late nights and early mornings in real laboratories. Colleagues have described how 2-Acetamido-5-aminopyridine’s consistent performance gives peace of mind amid tight project timelines. While no single molecule is ever a perfect solution, this intermediate’s versatility means it often features in brainstorming sessions when tackling tricky synthesis challenges.
Technicians particularly appreciate its ease of filtration and recrystallization in development runs. Grad students and junior researchers find that a well-behaved intermediate can make complex project work less stressful, giving them time to focus on experimentation rather than troubleshooting ingredient setbacks.
Each step forward in chemical manufacturing boils down to the same question: which materials help transform a rough idea into a usable product? For many, 2-Acetamido-5-aminopyridine answers that question with reliability and precision born from time-tested chemical properties.
For anyone purchasing or working with chemical intermediates, staying informed about evolving industry standards and regulatory priorities matters. Evolving guidelines mean that compounds like 2-Acetamido-5-aminopyridine must come with up-to-date analysis reports and transparent traceability. This isn’t driven just by bureaucracy; it reflects a deeper awareness of safety and ethical supply chains.
As automation grows in both research and quality control labs, documentation and consistent performance ensure these systems can trust the materials they process. Accurate lot tracing prevents cross-contamination and helps track down causes in the rare case of unexpected reactions. Open communication between labs and suppliers builds a culture of troubleshooting and shared improvement.
Countless advances rely on tools that deliver every time, not just under ideal conditions. 2-Acetamido-5-aminopyridine doesn’t need a lot of fuss, just attention to straightforward storage and clear documentation. Project leaders I’ve worked with weigh the cost of switching reagents against the risk of unpredictable results. By keeping a steady supply and fostering shared best practices, teams get more out of their research budgets and time.
Materials with a dependable track record let research and production teams take on new challenges with fewer setbacks. Looking ahead, as multi-step syntheses grow more elaborate and product quality requirements rise, intermediates like 2-Acetamido-5-aminopyridine will likely retain their importance in R&D pipelines, pharmaceutical scale-up routines, and specialized manufacturing operations.
Picking the right intermediate — just like picking the right wrench for a repair — shapes the whole process. Based on what I’ve seen in chemical labs and research hubs, 2-Acetamido-5-aminopyridine continues to earn a place in many toolkits. Experience counts, both in the molecules you work with and the sources you trust. Reliable chemical building blocks let more teams move faster from concept to reality, meeting tighter deadlines and stricter standards as industries evolve.
To move research and development ahead confidently means counting on compounds with a record of delivering results. In that sense, 2-Acetamido-5-aminopyridine stands as a practical tool for innovative chemistry, bridging the needs of today’s researchers with the possibilities of tomorrow’s breakthroughs.
