|
HS Code |
202263 |
| Cas Number | 61935-89-1 |
| Molecular Formula | C6H2Cl2N2 |
| Molecular Weight | 173.00 g/mol |
| Iupac Name | 2,3-dichloro-5-cyanopyridine |
| Appearance | White to light yellow crystalline powder |
| Melting Point | 74-78°C |
| Density | 1.47 g/cm³ (approximate) |
| Solubility | Soluble in organic solvents such as DMSO and DMF; slightly soluble in water |
| Purity | Typically ≥98% |
| Smiles | C1=CN=C(C(=C1Cl)C#N)Cl |
| Inchi | InChI=1S/C6H2Cl2N2/c7-5-2-1-4(3-9)6(8)10-5 |
| Storage Conditions | Store at cool, dry, and well-ventilated place; keep container tightly closed |
As an accredited 2,3-Dichloro-5-cyanopyridine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 250 grams of 2,3-Dichloro-5-cyanopyridine is packaged in a sealed amber glass bottle with a tamper-evident screw cap. |
| Container Loading (20′ FCL) | Container Loading (20′ FCL): 12 metric tons packed in 480 fiber drums, each containing 25 kg of 2,3-Dichloro-5-cyanopyridine. |
| Shipping | 2,3-Dichloro-5-cyanopyridine is typically shipped in tightly sealed containers to prevent moisture and contamination. It must be labeled in accordance with hazardous materials regulations. The chemical should be stored and transported in a cool, dry place, away from incompatible substances, with proper protective equipment used during handling to ensure safety. |
| Storage | 2,3-Dichloro-5-cyanopyridine should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area away from direct sunlight and incompatible substances such as strong oxidizers. Avoid moisture exposure. Store at room temperature and label the container clearly. Use appropriate personal protective equipment (PPE) when handling to prevent skin or eye contact. |
| Shelf Life | **2,3-Dichloro-5-cyanopyridine** typically has a shelf life of 2-3 years when stored in a cool, dry, airtight container. |
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Purity 99%: 2,3-Dichloro-5-cyanopyridine of purity 99% is used in pharmaceutical intermediate synthesis, where it ensures high yield and purity of the final active ingredient. Melting Point 92°C: 2,3-Dichloro-5-cyanopyridine with a melting point of 92°C is used in agrochemical manufacturing, where it provides thermal stability during formulation. Particle Size <50 µm: 2,3-Dichloro-5-cyanopyridine with particle size less than 50 µm is used in catalyst preparation, where it promotes homogeneous dispersion in catalytic systems. Moisture Content <0.2%: 2,3-Dichloro-5-cyanopyridine featuring moisture content below 0.2% is used in fine chemical applications, where it prevents hydrolytic degradation of sensitive compounds. Stability Temperature up to 120°C: 2,3-Dichloro-5-cyanopyridine with stability temperature up to 120°C is used in polymer modification, where it maintains structure and reactivity under processing conditions. Residual Solvents <100 ppm: 2,3-Dichloro-5-cyanopyridine with residual solvents below 100 ppm is used in electronic materials synthesis, where it minimizes contamination and ensures device reliability. |
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Every so often, a compound pops up that reshapes the way we think about efficiency and versatility in chemical synthesis. 2,3-Dichloro-5-cyanopyridine stands out as one of those dependable backbone molecules—simple in formula, but packed with functional potential. Drawing from real-world labs, its presence often marks a turning point for research teams aiming to build intricate and valuable structures in pharmaceuticals, agrochemicals, and advanced materials.
Looking at its molecular formula—C6H2Cl2N2—it quickly becomes clear what makes this compound so intriguing. The pyridine ring, a staple in organic chemistry, carries two chlorine atoms at the 2 and 3 positions, along with a cyano group poised at the 5 position. This arrangement does more than decorate the molecule—it shapes how it reacts under diverse conditions, broadening its use in cross-coupling reactions or nucleophilic aromatic substitution. Comparing to other pyridine derivatives, which often swap out ornaments for reactivity or cost, this specific substitution pattern on 2,3-Dichloro-5-cyanopyridine creates a perfect blend of functional groups for further chemical modification.
While other chlorinated pyridines might crowd the market, most lack this particular alliance between two adjacent chlorine atoms and a tightly bound cyano group. The result—a greater degree of synthetic flexibility, letting chemists reach a wider portfolio of downstream products with fewer synthetic steps. That means less waste, reduced need for complicated protecting groups, and often, a more direct path to the target molecule.
Working with this compound in practice, purity and physical consistency matter as much as reactivity. Standard lab or industrial grades reach purities above 98%, often appearing as a white-cream crystalline powder. The melting point usually hovers just below 100°C, making storage manageable in typical chemical warehouses without needing any fancy refrigeration. Solubility leans toward polar organic solvents, like DMF or acetonitrile, reinforcing its suitability for lab-scale or pilot plant applications in modern synthetic protocols.
Unlike some cousins in the pyridine family that fill air with harsh odors, 2,3-Dichloro-5-cyanopyridine tends to be milder, which reduces headaches—for staff and ventilation systems alike. Handling stays straightforward under proper laboratory conditions, and no unexpected volatility rears up to disrupt workflow.
Years of hands-on experience in the laboratory and factory floor show that 2,3-Dichloro-5-cyanopyridine turns up most often during preparation of active pharmaceutical ingredients. Its unique reactivity allows for selective substitution reactions to build complex molecules without tedious detours. In developing antiviral or anticancer agents—a field where speed and precision can save years and millions—this compound serves as a stepping stone, introducing diverse functional groups without triggering unwanted side-reactions.
On the crop protection side, global demand for new pesticides and herbicides drives continuous search for versatile intermediates. Here, the cyano group in 2,3-Dichloro-5-cyanopyridine gives plant scientists more room to tweak toxicity profiles or degradation rates, aiming for safety and efficacy balanced with environmental protection. Teams looking to develop new insecticides or fungicides often cite the ease of installing further functional units on the pyridine framework, cutting down on process development time while meeting regulatory standards.
In the realm of advanced electronics, complex pyridine-based compounds end up as ligands in OLED displays or catalysts in modern batteries. Synthesizing these materials with precision requires access to reliable building blocks, and the double chlorine-cyano configuration makes 2,3-Dichloro-5-cyanopyridine a staple for research and pilot-scale innovation. These aren’t just marginal improvements—these molecules directly improve the lifespans and efficiencies of next-generation products.
Plenty of pyridine compounds crowd catalogs and warehouses, so it’s fair to ask: what exactly puts 2,3-Dichloro-5-cyanopyridine a notch above the rest? Simple—its pattern of substitution leads to a broader range of reactivity, paired with higher selectivity in downstream chemistry. While plenty of pyridine derivatives sport a single halogen or a cyano at another position, the synergy between two chlorines at the 2 and 3 spots with the cyano at 5 brings several benefits.
Compare this with more typical halopyridines lacking that crucial cyano group, or with compounds carrying more complex or branched substituents. The alternatives might lock chemists into narrow synthetic routes, or demand expensive purification to separate out byproducts. Here, 2,3-Dichloro-5-cyanopyridine sidesteps those traps, giving researchers a smoother runway for their next innovation cycle.
All chemicals, no matter how useful, carry some baggage. Over the years, one recurring challenge with 2,3-Dichloro-5-cyanopyridine has been its relative scarcity on short notice, especially at research scales. Demand from pharmaceutical startups and specialty chemical houses sometimes spikes unpredictably, making just-in-time supply chains tough to manage. Experienced procurement teams keep buffer stocks and trusted supplier relationships to dodge these hiccups.
Health and safety come into play as well. Though not the most hazardous member of its class, consistent handling protocols must remain in place. Contact with skin or eyes triggers irritation, and the material bioaccumulates without proper disposal. Most organizations ensure closed handling systems and enforce routine staff refresher training to keep incidents rare.
From an environmental regulatory standpoint, the halogenated pyridine framework resists natural breakdown. Waste management teams in advanced labs and production sites prioritize capturing and neutralizing spent reactants. Many labs collaborate with certified chemical recyclers or partner with academic groups looking to upcycle waste into less harmful substances—a strategy driven both by legal pressure and the values of an environmentally aware workforce.
Long-term chemical supply management gains from early and open dialogue with key manufacturers. Rather than risking improvisation every time a lab runs low, seasoned teams secure annual contracts or work with distributors boasting large, stable stocks. In my consulting work, the difference between a delayed launch and a timely patent application has more than once come down to secure sourcing strategies for this crucial intermediate.
Health and safety teams move beyond the baseline safety data sheet. They organize in-house demonstrations recognizing real-world spill scenarios, run drills, and fund ongoing ventilation upgrades. Pharmacies and plant managers supporting safety cultures see fewer lost workdays and reduced insurance claims—direct testimony to the compound’s manageable but real risks.
Tackling environmental problems means staying ahead of regulation. Companies successful in long-haul compliance set up pre-treatment stations for liquid byproducts and connect with research institutions seeking new detoxification catalysts. Others invest in microreactor flow technology, which clamps down on waste output by producing only as much as the next stage needs—eliminating traditional batch excess and delivering remarkable cost reductions when scaled.
The push for greener approaches suggests another path: development of bio-based routes to pyridine cores and their derivatives. Leaders in the field keep a close eye on metabolic engineering and biocatalysis—areas where recent breakthroughs hint at practical methods for feeding biomass into chemical synthesis pipelines, sidestepping some halogen-handling problems entirely.
If experience has taught one key lesson, it’s that simplicity in a starting material powers big leaps in applied science. 2,3-Dichloro-5-cyanopyridine won’t be the last word in synthetic chemistry, but its user-friendly profile, broad reactivity, and reliable performance make it a quiet favorite among chemists trying to solve tough design challenges across industries.
Drug makers eyeing tighter timelines for clinical candidates often go straight to the 2,3-Dichloro-5-cyanopyridine page in the catalog. With this compound, they reliably generate lead molecules for antivirals, antibacterial agents, and enzyme inhibitors that address an expanding array of medical needs. Teams that choose this route trim months off development work, and some of today’s most promising experimental compounds trace their origins right back to this solid, often-overlooked workhorse.
Outside pharma, its adaptability finds a growing home among material scientists. As efforts ramp up in electronics, energy storage, and optical materials, the search for easily functionalized core structures grows ever more critical. 2,3-Dichloro-5-cyanopyridine’s track record of delivering high yields and reliable selectivity places it front and center in the toolbox of developers at startups and research universities who thrive on speed and accuracy.
For many small and medium businesses, the true value emerges at the scale-up stage. Unlike more exotic intermediates that demand specialized reactors or finicky purification schemes, 2,3-Dichloro-5-cyanopyridine holds up under the pressures of kilogram and ton-scale synthesis. Process engineers working under strict timelines report smoother scale-ups and more predictable outputs, which is essential for locking up supply contracts or impressing early investors.
Supporting the safe and effective use of this compound relies not just on robust manufacturing, but also on consistent education and knowledge-sharing. Technical leaders encourage regular workshops or seminars on the latest reaction protocols and environmental updates. Professional societies and open-access journals keep the pipeline of tested, practical information flowing, so best practices for optimizing each reaction step don’t remain locked in isolated labs.
At conferences, research teams swap case studies on clever uses and novel conversions of 2,3-Dichloro-5-cyanopyridine, opening doors to new classes of products and revealing potential pitfalls before they surprise the unprepared. This culture of open exchange, in my experience, prevents costly mistakes and sparks the kind of incremental progress that compounds over time into real breakthroughs.
Meeting today’s market pressures demands adaptability, and 2,3-Dichloro-5-cyanopyridine fits well into this ethos. As global supply chains tighten and demand for specialized molecules increases, organizations that invest in robust handling and progressive environmental management hold the edge. New purification technologies and digital tracking of chemical stocks now underpin smoother ordering and reduced losses, improving both profit margins and the environmental footprint.
Some labs experiment with catalytic processes designed to minimize waste or reclaim spent reagents. Whether the route is classic or cutting-edge, success depends on a solid, versatile starting material—reinforcing why this multi-substituted pyridine continues to attract attention. Looking at emerging trends in molecular design, the future points to even higher demand as more drug scaffolds and engineered materials call for tailored chemical starting points that classic intermediates just can’t deliver.
For decades, synthetic chemists valued 2,3-Dichloro-5-cyanopyridine for what it enables: faster, more reliable journeys from blueprint to reality, whether building complex medicinal compounds or paving the way for better-performing materials. The compound’s track record and measurable impact in laboratories and manufacturing sites underscores its continued relevance. As green chemistry advances and digital tools ease everyday lab life, expect this veteran molecule not to be replaced, but rather reimagined for tomorrow’s challenges, enabling another generation to push the boundaries of what’s possible in chemical synthesis.
