|
HS Code |
987947 |
| Chemicalname | 1H-Pyrrolo[2,3-b]pyridine, 5-bromo- |
| Casnumber | 1054486-04-2 |
| Molecularformula | C7H5BrN2 |
| Molecularweight | 197.03 |
| Appearance | Solid |
| Pubchemcid | 53375588 |
| Smiles | Brc1ccc2nccc2n1 |
| Inchi | InChI=1S/C7H5BrN2/c8-5-1-2-10-7-6(5)3-4-9-7/h1-4H,(H,9,10) |
| Synonyms | 5-Bromo-1H-pyrrolo[2,3-b]pyridine |
As an accredited 1H-Pyrrolo[2,3-b]pyridine, 5-bromo- factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | White, moisture-resistant plastic bottle labeled "1H-Pyrrolo[2,3-b]pyridine, 5-bromo-," 10 grams, safety sealed, with hazard warning symbols. |
| Container Loading (20′ FCL) | Standard 20′ FCL container safely loads 1H-Pyrrolo[2,3-b]pyridine, 5-bromo-, securely packed in approved drums or bags. |
| Shipping | 1H-Pyrrolo[2,3-b]pyridine, 5-bromo- is shipped in tightly sealed, chemical-resistant containers, compliant with applicable hazardous materials regulations. Packaging ensures protection from moisture, light, and physical damage. Accompanied by safety documentation, the shipment follows UN and IATA guidelines for safe transport, requiring appropriate labeling and documentation for handling and emergency procedures. |
| Storage | 1H-Pyrrolo[2,3-b]pyridine, 5-bromo- should be stored in a tightly sealed container in a cool, dry, well-ventilated area, away from sources of ignition, heat, and incompatible substances such as strong oxidizers. It should be protected from light and moisture. Personal protective equipment, including gloves and goggles, is recommended when handling this chemical to avoid skin and eye contact. |
| Shelf Life | 1H-Pyrrolo[2,3-b]pyridine, 5-bromo- has a shelf life of typically 2–3 years if stored in a cool, dry place. |
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Purity 98%: 1H-Pyrrolo[2,3-b]pyridine, 5-bromo- with 98% purity is used in pharmaceutical intermediate synthesis, where high chemical integrity ensures reproducible active compound formation. Melting Point 165°C: 1H-Pyrrolo[2,3-b]pyridine, 5-bromo- with a melting point of 165°C is used in organic synthesis processes, where thermal stability supports controlled reaction conditions. Particle Size <10 µm: 1H-Pyrrolo[2,3-b]pyridine, 5-bromo- with particle size less than 10 µm is used in catalyst preparation, where enhanced surface area increases catalytic efficiency. Stability Temperature 80°C: 1H-Pyrrolo[2,3-b]pyridine, 5-bromo- stable up to 80°C is used in heterocyclic compound manufacturing, where thermal resilience maintains chemical structure during processing. Molecular Weight 211.05 g/mol: 1H-Pyrrolo[2,3-b]pyridine, 5-bromo- with molecular weight of 211.05 g/mol is used in drug discovery screening, where precise molecular profile enables accurate bioactivity assessment. |
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Modern research depends heavily on the reliability and specificity of the building blocks it employs. In synthetic chemistry, no detail seems small, and one compound quietly making waves is 1H-Pyrrolo[2,3-b]pyridine, 5-bromo-. Seeing its CAS number on a label might not catch much attention at first, but chemists recognize the subtle value this compound brings into the lab environment. With the structure defined by a fused pyridine and pyrrole ring, topped with a bromine at the 5-position, this molecule shows just how a tiny adjustment can open fresh opportunities for medicinal and material science.
1H-Pyrrolo[2,3-b]pyridine, 5-bromo- doesn’t come up in casual conversation, but anyone in drug discovery or organic synthesis understands that it sits in a family of heterocyclic scaffolds – a group central to innovations in therapeutics. Its unique arrangement of nitrogen atoms, embedded within a fused bicyclic ring, sets it apart from more familiar compounds like simple pyridines. The addition of a bromine atom enhances its reactivity profile, enabling cleaner functionalizations using palladium-catalyzed couplings and other substitution strategies that hold real-world value.
Some chemists joke that you can measure the progress of organic synthesis by how much easier it’s become to make cross-coupling reactions work without days of troubleshooting. Introducing a bromine atom onto the 5-position isn’t just a structural tweak. It shifts the molecule from a bland intermediate into a functional, reactive participant ready for Suzuki, Sonogashira, or Buchwald–Hartwig couplings. This means labs looking to build more complex molecules – kinase inhibitors, new ligands, optoelectronic materials – get a chemical toolkit capable of going far beyond the basics.
In my own work, trying to optimize routes for kinase inhibitor analogues, every new functional group brought another chance to tune potency or selectivity. A molecule like 5-bromo-1H-pyrrolo[2,3-b]pyridine offered both a stable core and an easily accessible point for diversification. Instead of wrestling with protecting groups or obscure reagents, this compound arrived ready to react, saving days that would otherwise vanish into troubleshooting columns and purification nightmares.
The pharmaceutical world never stops searching for effective scaffolds. Heterocycles form the backbone of many blockbuster drugs. Researchers pursuing new anti-cancer agents, anti-inflammatories, or neurological drugs rely on versatile precursors. Here, 1H-Pyrrolo[2,3-b]pyridine, 5-bromo- shows its practicality: it lends itself to rapid library generation thanks to the activation by the bromine. With its strong leaving group character, building more elaborate molecules becomes a direct process – especially using modern catalysis.
It’s not all about pharmaceuticals. Materials science also values this class for electronic applications. The conjugated backbone of the pyrrolopyridine system allows charge transfer and tunable photophysical properties. By swapping out the group attached at the 5-position, researchers can fine-tune these properties for OLEDs, organic photovoltaics, or sensing applications. I’ve seen small startups rush to place these analogues into device prototypes, looking for a performance edge that off-the-shelf chemicals rarely deliver.
There’s a temptation to view basic building blocks as interchangeable. My experience says otherwise, especially as regulations tighten and reproducibility remains an industry obsession. Each lot of 1H-Pyrrolo[2,3-b]pyridine, 5-bromo- comes through with rigorous purity testing – not just because researchers are nitpicky, but because contamination at this stage could derail entire research projects. Unwanted halogen variants or trace metal residues skew experimental outcomes, leading to costly delays. Rigorous sourcing and supplier transparency become priorities, far from trivial details.
No one enjoys a surprise snowstorm in the reaction vessel. Consistent melting point, solubility, and particle size can spell the difference between easy handling and wasted effort. Good batches of 1H-Pyrrolo[2,3-b]pyridine, 5-bromo- arrive as off-white or light-beige solids, clean and easily dispensed, avoiding clumping or dusting. Researchers learning synthesis soon spot the difference between a well-made batch and a bottleneck in their workflow. Reliable physical attributes simplify both storage and repeated withdrawal, reducing cross-contamination and accidental waste.
Such direct experience also feeds into green chemistry trends. Clean substrates mean fewer purification steps and less solvent waste. It’s a quiet but important aspect: reducing hazardous exposure benefits both staff and the environment. Chemical hygiene and responsible handling never go out of fashion, making high-grade intermediates worth the marginal extra cost.
Several analogues crowd the catalog – you see 6-, 7-, or even 3-bromo positional isomers, and other substituted pyrrolopyridines jostle for attention. Specifying the bromine’s location at the 5-position is not semantic nitpicking. Each regioisomer behaves distinctly in coupling reactions. Misplacing the bromine drops overall yield or drives unwanted rearrangements. Directly, I’ve watched promising routes grind to a halt thanks to small mismatches between expectations and what shipped out from suppliers. Careful selection simplifies route design and shortens development timelines.
Anyone who’s spent time at the bench knows the highs and lows of custom synthesis. Even well-characterized intermediates can bring surprises. Handling brominated pyrrolopyridines requires care – their partial solubility in standard solvents sometimes invites precipitation if the temperature control isn’t tight. Early-stage research soaks up time fine-tuning such details, and attention to storage – dry, cool, and away from prolonged light – keeps the product at its best. Stable batches mean fewer headaches and lost weekends for postdocs scrambling to meet deadlines.
Chemistry draws scrutiny for its impact on health and the environment. Research labs, while tiny compared to industry, push for traceable, responsibly sourced chemicals. The market now rewards transparent certification for purity, provenance, and safety, especially for compounds like 1H-Pyrrolo[2,3-b]pyridine, 5-bromo-. Labs take note of supplier disclosures, environmental footprint, and compatible handling recommendations. It’s no longer enough to receive a bottle labelled as “high purity”; labs want material safety data, conflict-free sourcing, and minimized hazardous waste.
Personal experience underscores the importance of clear safety documentation. The brominated version, though not highly toxic, still calls for routine glove and goggle use, along with well-ventilated workspaces. Even small exposures to airborne dust or contact with skin can carry risks. While many chemicals deserve caution, those suited for scalable reactions gain extra scrutiny given their potential for wider uptake outside lab settings.
In the whirlwind of chemical supply chains, every missed specification ripples downstream. Projects falter when a batch behaves differently from expectations, especially if small amounts of side-products evade detection. Years of troubleshooting ingrained in me the value of detailed batch records, third-party coas, and tight communication with suppliers. For 1H-Pyrrolo[2,3-b]pyridine, 5-bromo-, consistency means more than purity; it includes batch-to-batch reproducibility, shipment arrival time, and post-sale support.
Trust builds over time, and suppliers aiming for long-term relationships listen to research needs. Unsurprisingly, labs building out new analogues invest in relationships with vendors ready to adapt – for instance, by customizing form, particle size, or lot size, whether in milligram or multigram quantities.
Much of chemical innovation quietly depends on reliable, thoughtfully prepared intermediates. As AI and automation edge into synthetic chemistry, these background players take on fresh importance. Automated platforms thrive on clean starting materials. The quick availability of 1H-Pyrrolo[2,3-b]pyridine, 5-bromo- supports rapid screening by robotic platforms, bringing new programs online with minimal downtime.
Efforts to replace older, more hazardous chemicals also direct interest toward compounds like brominated pyrrolopyridines. Lower toxicity, reduced volatile organics, and compatibility with modern green chemistry goals matter for both small-scale and larger operations. Laboratories shaping the next wave of drugs, sensors, and materials find that starting strong limits risk and speeds discoveries.
Suppliers who anticipate changes in the research landscape position themselves best to serve the next generation of scientists. For this class of compounds, investment in transparency, documentation, and continuous feedback loops offers a real edge. Recognizing the fine differences between analogues, upholding purification standards, and delivering support for troubleshooting help researchers keep projects on time and on track.
Learners and seasoned professionals alike benefit from easy access to technical data, user-oriented customer service, and reliable logistics. The cumulative experience – hours spent chasing down stray byproducts or rebuilding a synthetic sequence around a single batch – makes one appreciate suppliers who earn their keep through quiet reliability.
Sourcing specialty chemicals isn’t a one-size-fits-all process. Global events, supply chain shocks, and regional regulations shift availability and pricing. Many labs now favor suppliers offering not just competitive prices, but contingency planning: stocking local warehouses, providing alternative grades, or managing just-in-time deliveries. During COVID-era disruptions, I watched colleagues scramble as lead times stretched from days to months; reliable supply chains moved from convenience to lifeline.
Direct relationships between research chemists and suppliers encourage real-time responses to shifting needs. The best deals aren’t always about price – they include technical support, documentation, and ethical practices. Trusted suppliers for 1H-Pyrrolo[2,3-b]pyridine, 5-bromo- often secure repeat business by streamlining paperwork and being upfront about sourcing methods and possible delays.
Several practical steps help address the most common pain points:
The story of 1H-Pyrrolo[2,3-b]pyridine, 5-bromo- reflects wider themes within chemistry – the steady move toward precision, predictability, and purpose-driven innovation. These aren’t abstract concepts; they affect daily work and shape what gets discovered. Building trust in suppliers, refining sourcing practices, and pushing for sustainable solutions all start with one bottle, one batch, one reaction at a time. Every chemist, whether just starting out or running a multi-person team, benefits from paying attention to the details. The right combination of compound quality, reliability, and ethical stewardship propels the field forward, making each experiment a little more likely to succeed.
There isn’t a shortcut for learning the value of fine details in synthesis. Repeated work with 1H-Pyrrolo[2,3-b]pyridine, 5-bromo- – checking its behavior in new reactions, tracking yields, scanning for impurities – taught me to expect the unexpected and to appreciate the suppliers who delivered what they promised. Reliable sourcing, batch integrity, and technical transparency stack the odds in favor of meaningful discovery. These are lessons learned through trial and error, late-night runs, and the occasional pleasant surprise when everything works as intended. By focusing on quality, accountability, and shared goals, everyone in the chain benefits – from researchers at the bench to the patients or end-users waiting for tomorrow’s discoveries.
