| Names | |
|---|---|
| Preferred IUPAC name | N-(2-chloroacetyl)-3-oxobutanamide |
| Other names | N-(2-Chloroacetyl)aniline 2-Chloro-N-phenylacetamide 2-Chloroacetoacetanilide Chloroacetoacetanilide |
| Pronunciation | /ˈklɔːr.oʊ.əˌsiː.təʊˌæs.ɪˈtæn.ɪ.laɪd/ |
| Identifiers | |
| CAS Number | N |
| Beilstein Reference | Beilstein Reference: 2041459 |
| ChEBI | CHEBI:85145 |
| ChEMBL | CHEMBL253013 |
| ChemSpider | 147623 |
| DrugBank | DB14005 |
| ECHA InfoCard | 17d515b2-764a-409a-b93c-510f1ddb0b00 |
| Gmelin Reference | GMELIN 83394 |
| KEGG | C14322 |
| MeSH | D002754 |
| PubChem CID | 86993 |
| RTECS number | AB5950000 |
| UNII | 21HPV8D10D |
| UN number | 2811 |
| Properties | |
| Chemical formula | C10H10ClNO2 |
| Molar mass | 197.63 g/mol |
| Appearance | White to off-white crystalline powder |
| Odor | Odorless |
| Density | 1.315 g/cm³ |
| Solubility in water | Slightly soluble in water |
| log P | 1.54 |
| Vapor pressure | 0.0000195 mmHg at 25°C |
| Acidity (pKa) | 14.37 |
| Basicity (pKb) | 14.90 |
| Magnetic susceptibility (χ) | -62.0×10⁻⁶ cm³/mol |
| Refractive index (nD) | '1.583' |
| Viscosity | Viscous liquid |
| Dipole moment | 3.90 D |
| Thermochemistry | |
| Std molar entropy (S⦵298) | 359.6 J·mol⁻¹·K⁻¹ |
| Std enthalpy of formation (ΔfH⦵298) | -178.6 kJ/mol |
| Std enthalpy of combustion (ΔcH⦵298) | -398.6 kJ/mol |
| Pharmacology | |
| ATC code | N01AX10 |
| Hazards | |
| Main hazards | Harmful if swallowed, causes serious eye irritation, causes skin irritation |
| GHS labelling | GHS02, GHS07 |
| Pictograms | GHS07 |
| Signal word | Warning |
| Hazard statements | H302, H315, H319, H335 |
| Precautionary statements | P261, P264, P270, P271, P272, P273, P280, P301+P312, P302+P352, P305+P351+P338, P312, P330, P391, P403+P233, P405, P501 |
| Flash point | 155 °C (311 °F; 428 K) |
| Autoignition temperature | > 380 °C |
| Lethal dose or concentration | LD₅₀ (oral, rat): 1,410 mg/kg |
| LD50 (median dose) | LD50 (median dose): 830 mg/kg (rat, oral) |
| NIOSH | SN8750000 |
| PEL (Permissible) | PEL (Permissible Exposure Limit) for 2-Chloroacetoacetanilide: Not established |
| REL (Recommended) | No REL established |
| Related compounds | |
| Related compounds | Acetoacetanilide 2-Bromoacetoacetanilide Chloroacetamide Chloroacetanilide Acetoacet-o-toluidide |
| Product Identification | Description and Manufacturer Commentary |
|---|---|
| Product Name & IUPAC Name |
Product Name: 2-Chloroacetoacetanilide IUPAC Name: N-(2-Chloroacetyl)acetanilide The IUPAC nomenclature reflects substitution at the acetanilide core, where a chloroacetyl group attaches at the nitrogen. Manufacturers use this name in regulatory reporting and export documentation to match international customs entries, eliminating ambiguity between similar substituted acetanilides. |
| Chemical Formula |
C10H10ClNO2 Molar mass: Depends on isotope ratio and salt form, but nominal composition follows this formula. Process engineers monitor formula consistency against possible hydrolysis, chlorination variability, and solvent inclusion. Raw material purity and reaction completeness play a role in final assay: any deviation visible in elemental analysis triggers additional purification steps. |
| Synonyms & Trade Names |
2-Chloro-N-phenylacetoacetamide N-Phenyl-2-chloroacetoacetamide Chloroacetoacetanilide Industry tends to consolidate synonyms for batch reconciliation. Naming conventions at shipment often use whatever local or customer-specific naming standard aligns with import licenses and customs entries. Discrepancy between local and international names can impact HS code assignment and customs clearance, so we document all known variations during the sales process. |
| HS Code & Customs Classification |
HS Code: 2924.29 This code applies to acyclic amides and their derivatives, and is selected based on product structure rather than downstream application. Regional differences in customs coding can cause reclassification risk; therefore, we base export paperwork on harmonized system guidelines, supported by structure-based technical justification as required by regulatory authorities. Variations may arise if the importing country applies more granular codes—export compliance checks all cross-referenced regulations before documentation release. |
Industrial batches of 2-Chloroacetoacetanilide typically produce a crystalline solid. The form and color may vary depending on grade and purification approach, with technical grades often showing an off-white to light yellow appearance. Odor is not typically strong or distinct at ambient temperature.
Melting point often serves as a quick screening metric for purity and batch identity, though it shows grade dependency and fluctuates with different impurity profiles. Boiling point is less relevant for handling due to decomposition risk before boiling. Flash point and density values are rarely used for routine QC, but may be referenced during incident investigations or batch release for hazardous goods classification.
Products from stable synthesis and proper drying demonstrate shelf stability under recommended storage. Residual moisture and alkaline contaminants increase risk of hydrolysis or degradation, especially in bulk packaging or when subjected to temperature fluctuations. Reaction with strong oxidants or bases generates risk of decomposition or hazardous byproducts. Material shows good compatibility with most organic solvents commonly used in downstream processing.
Solubility differs by grade purity and preparation history. Technical quality typically dissolves in polar aprotic solvents, with limited solubility in water and enhanced solubility in solvents like acetone or DMF. Solution preparation for formulation requires rigorous pre-dissolution filtration to prevent undissolved particulates carried by purification-variant technical grades. Proper agitation and temperature can produce batch-to-batch consistency in formulated solutions.
| Property | Technical Grade | Purer Grade | Test Method |
|---|---|---|---|
| Identity (IR/HPLC) | Complies | Complies | In-house / Standard IR, HPLC |
| Appearance | Off-white/yellow | White | Visual |
| Melting Point Range | Grade dependent | Narrower range | Capillary/DSC |
| Assay (by HPLC) | Typically above 97% | Defined as per grade | HPLC |
| Impurities | Grade dependent | Lower | HPLC/GC/MS |
| Moisture | Procedural control | Tightly controlled | Karl Fischer |
Exact limits for impurities, moisture content, and other parameters follow internal batch documentation and specific customer requirements. Major quality drivers include purity by HPLC, low residual solvents (if present), and absence of persistent synthetic byproducts.
Batch impurity signatures depend on the synthesis route and quality of raw materials. Maximum allowable limits are set according to intended application, with stringent specifications required for higher value or regulated downstream usage.
Most routine analyses follow internal procedures harmonized to recognized analytics such as HPLC for assay, identity by IR or NMR, and Karl Fischer for water determination. Customer audits occasionally require demonstration of compliance with region-specific chemical testing directives.
Common raw materials include aniline derivatives and 2-chloroacetoacetyl chloride (or equivalent acid chlorides). Selection focuses on supplier consistency, impurity control, absence of colored or tar-forming byproducts, and lot traceability. Batch discrepancies often track back to variations in chloroacetyl chloride quality or unreactive aniline intermediates.
Process generally follows acylation of an aniline core with a chloroacetyl functionality under controlled conditions. Choice of solvent and temperature control is critical for suppressing byproduct formation or hydrolysis. Some routes employ phase transfer or catalyst optimization to boost conversion efficiency and reduce hazardous waste.
Key control points span raw material charging rate, exotherm management, endpoint monitoring, and effective quenching. Purification may involve recrystallization, filtration, and controlled drying. Impurity carryover and byproduct management require frequent in-process checks, especially for color-sensitive or low-residue product grades.
Each lot undergoes release testing per agreed specification profile. Batch history, reaction log, and deviation investigation reports determine eligibility for final release. Internal criteria adapt to customer feedback and any observed downstream performance concerns.
Undergoes further acylation, substitution (notably nucleophilic displacement at the chloro group), or condensation depending on downstream requirements for dyes, agrochemicals, or intermediates. Reaction selectivity and yield depend strongly on product purity and moisture control in the starting material.
Industry practice varies in use of acid scavengers, temperature range, and solvent polarity. Chlorinated solvents are generally avoided for environmental compliance, favoring more sustainable alternatives where feasible.
Typical modifications include introduction of heterocycles or coupling reactions for pigment synthesis. Material compatibility requirements for these transformations influence the selection of supply grade.
Best practice advises storage in low humidity, cool conditions below ambient laboratory temperatures. Light exposure may influence color or decomposition risk, particularly on extended storage. Inert gas blanket typically reserved for large volume or long-term stock to prevent slow hydrolysis.
Standard HDPE or lined drum containers suit process-scale storage, though prolonged contact with reactive metals is avoided. Container integrity ensures protection from atmospheric ingress, odors, and cross-contamination risk from previous fills.
Shelf life depends on grade, storage environment, and packaging. Color darkening, increased odor, or detectable free acid formation are common signs of degradation. Onsite retesting is required for any stock approaching declared maximum hold period per batch documentation.
Standard hazard declarations for 2-Chloroacetoacetanilide cover damaging effects on skin and eyes by dust contact, and respiratory or gastrointestinal irritation on accidental inhalation or ingestion. Industrial use mandates gloves, goggles, and local ventilation. Dust control is enforced in high-throughput areas and at transfer stations.
Acute and chronic toxicity depends on exposure pathway and dose. Toxicity studies indicate moderate hazard, with cumulative risk for operators involved in repeated handling or process sampling. Official exposure limits may be set by local regulatory bodies. As a manufacturer, internal work area monitoring and PPE compliance form the backbone of worker protection. Spills or accidental dispersion require immediate containment and approved cleanup protocol.
2-Chloroacetoacetanilide production capacity reflects current demand patterns, raw material availability, and process throughput across our reactors. Batch output depends on the synthesis route (direct chlorination or stepwise acylation), as well as the handling of mother liquor and purification efficiency. Output can increase by process debottlenecking, but is usually constrained by critical raw material allocations and downstream drying and packing resources. Product availability responds to downstream pesticide and pigment industry orders, as well as commitments to repeat contractual buyers.
Lead time is influenced by both campaign batch scheduling and availability of technical-grade intermediates. Typical lot lead time ranges from two to four weeks, subject to grade specificity, ongoing campaign status, and shipping documentation requirements. Minimum order quantity is set according to grade, handling efficiency, and customer package preference, with higher-volume technical buyers able to coordinate full-container or multi-metric ton orders, and specialty users sourcing smaller packs subject to slot availability.
Packaging takes industrial compatibility, moisture protection, and downstream usage into account. Standard technical grades ship in fiber drums with double-polyethylene liners. Higher-purity or application-critical grades use sealed lining, nitrogen purging, or anti-static packaging based on sensitivity to humidity, oxidative degradation, or contamination risks. Palletizing is offered for supply chain stability. Custom labeling or traceability is provided for regulated export or customer audit.
Shipping aligns with Incoterms as specified in contract negotiations, predominantly FOB main port, CIF, or DAP for certain bulk users. Payment terms depend on trade histories, documentary credit standing, and regulatory jurisdictions, ranging from T/T advance for new buyers to longer settlement periods for established industrial customers. All international shipments include MSDS, COA, and regulatory documentation as per destination authority requirements.
Raw material cost arises mainly from chloroacetyl chloride and acetoacetanilide feedstock, both tied to upstream oil and bunker fuel trends and seasonal chemical demand cycles. Indirect costs arise from purification agents, energy required to drive chlorination, and solvent recovery losses. Fluctuation results from volatile trading in the basic chemical sector, plus specific incidents in logistics, regulatory restriction on precursor chemicals, or shifts in agrochemical demand that pull these supplies into competitive markets.
Key drivers for input chemical swings include plant shutdowns in main production basins, regulatory crackdowns on batch effluent or waste streams, shifts in supply chain logistics for hazardous precursors, and agricultural seasonality triggering uneven demand for pesticide intermediates. Regional policy changes and transportation cost hikes (especially for bulk container chemical logistics) tend to magnify unit cost variation, forcing periodic price realignment.
Price points are not fixed universally; end-use segment, purity, and documentation requirements drive grade-specific pricing. Export-grade product with enhanced retention packaging, purity traceable by batch numeric standards, and regulatory certification fetches a premium over standard technical grade for blended feedstock use. High-purity grades for pigment and pharmaceuticals command significant upcharge for validated impurity profile, with costs compounded by additional test requirements, controlled chain-of-custody, and audit-acceptable release documentation.
Manufacturers in eastern China and South Asia dominate the world supply chain for 2-Chloroacetoacetanilide, with most downstream usage in crop protection, pigment, and specialty intermediate manufacturing. Periods of export restriction (notably during compliance crackdowns or port disruption) tend to create short-term price spikes. Demand volumes track closely to sowing cycles and agrochemical project launches, with pigment and intermediate demand bringing some market stability in off-seasons.
United States: Demand linked to herbicide formulations and specialty pigment applications. Stringent audit, documentation, and import chemical certification processes impact supplier requirements.
European Union: Product access regulated under REACH, where pre-registration, byproduct analysis, and sustainable compliance documentation add to import costs. Large users pre-qualify suppliers based on recurring quality audits.
Japan: Market seeks ultra-high purity for pharma and electronic use. Supplier qualification is prolonged, and product traceability stringent. Minor volumes compared to US/EU but highest compliance scrutiny.
India: Both producer and consumer. Local regulatory environment subject to periodic change on effluent and handling controls; high competition in local technical-grade market, with patchy price discipline among smaller manufacturers.
China: Remains largest source for export and domestic consumption. Production directed by environmental permit status, local feedstock cost, and industrial policy on hazardous chemical handling.
By 2026, value of 2-Chloroacetoacetanilide is expected to track continued volatility in oil-derived chemical precursors, amplified by new regulatory compliance costs in major consumption regions. If feedstock bottlenecks or new environmental limits on byproduct streams from leading production provinces materialize, both spot prices and long-term contract rates face upward pressure. Stable product grades negotiated under framework supply agreements could moderate price swings but spot market procurement will remain sensitive to both raw material volatility and logistics costs.
Forecasts reference aggregated distributor price reporting, public customs export records, regional chemical industry publications, and historical contract settlement averages. Methodology weighs direct feedstock indices, regional plant capacity news, seasonal usage patterns, and import/export regulatory updates for triangulation. Key inputs validated against repeat tender and bilateral contract data where available.
Ongoing tightening in environmental compliance at coastal plant clusters has temporarily reduced export-grade technical output. Reallocation of feedstock to domestic herbicide formulation or export contract priorities triggers supply instability, notably in peak agricultural cycles. Buyers are responding by forward-booking larger lots against forecast risk.
Emerging market restrictions on precursor chemicals and higher proof-of-traceability for export consignments into OECD economies have lengthened batch qualification and release schedules. New audit requirements for REACH and other frameworks are driving record documentation and impurity profiling, especially for high-purity lots.
Process departments have focused on impurity tracing at critical reaction nodes, improving internal auditing of batch consistency, and retooling purification streams to guard against off-spec lot rejections. Commercial teams are recalibrating packaging and export processes to match new destination-specific compliance checklists, including shipment traceability upgrades and 24/7 digital access to batch data for customer assurance. Temporary supply disruptions are mitigated by dynamic load balancing between parallel synthesis lines and split shipping.
2-Chloroacetoacetanilide serves as an intermediate in agrochemical synthesis, pigment manufacturing, and pharmaceutical building-block production. Its function in each field relies heavily on the purity of raw materials, control of specific impurity profiles, and suitability for downstream transformation steps. In herbicide and pesticide synthesis, product stability, consistency in reactivity, and minimal trace contaminants support reliable formulation performance. For dye and pigment production, color shade, fineness, and chemical compatibility with coupling agents draw strict attention during grade assessment. Pharmaceutical intermediates require additional controls on unreacted starting materials and process-derived byproducts due to regulatory and safety scrutiny.
| Grade | Target Application | Primary Considerations |
|---|---|---|
| Technical | Agrochemicals Pigments |
Profile of allowed organic/inorganic impurities; batch-to-batch reproducibility |
| High Purity | Pharmaceutical Intermediates | Stricter impurity limits; trace-level side product monitoring; additional analytical documentation |
| Custom Specification | Specialty Chemicals Custom Formulations |
Customer-driven release limits; project-oriented in-process controls; fine-tuned drying or particle sizing as specified |
Each project begins with a discussion of the end use. Herbicide synthesis, pigment dispersions, and pharma intermediate supply face different regulatory and technical hurdles—so the initial project scoping determines the minimum threshold for purity, impurity control, and physical form.
Agrochemicals and pharmaceuticals regularly demand documentation aligning with local and international safety and quality standards. Manufacturing teams clarify permitted impurity classes and reporting thresholds before grade selection. Custom documentation packages accommodate special registration markets.
Not every process tolerates the same impurity levels or residual solvents from synthesis and purification. Purity target discussions tie directly to downstream transformation efficiency, catalyst compatibility, and market registration. Analytical support enables batch-specific certification.
Large production campaigns tend to benefit from technical grades with extended process controls, while pilot-scale pharma or specialty projects often shift to high purity or custom-defined batches. Projected scale, frequency, and ongoing supply security shape the economic approach to grade specification.
Production- and quality-control teams provide test samples under real shipment conditions for laboratory and plant-scale evaluation. Customers routinely validate performance under actual use scenarios before firming bulk orders. Feedback from this technical validation can adjust specification points for subsequent batches.
Operating facilities adhere to established quality management frameworks designed for the chemical manufacturing sector. Every step, from incoming inspections of raw material lots to final product release, is governed by documented protocols tying each batch traceably to its production lifecycle. Most demanding applications depend on consistent records and traceable production history. Manufacturing teams maintain systematic calibration of weighing, blending, and analytical equipment, which minimizes incremental drift and avoids cumulative batch-to-batch deviation.
Customers in regulated and specialty markets often request documentation confirming compliance with region-specific regulations and internal acceptance limits. Depending on the required grade—whether technical or tailored for downstream processing—production selects appropriate quality checkpoints and works closely with clients to define acceptance criteria for key analytes and purity profiles. Product certifications respond to actual batch analyses, encompassing moisture, assay, color, and main impurity profiles. Upon request, compliance declarations referencing specific local or international regulatory requirements may also be issued, once assessed against internal data.
Each shipment leaves the site with full analytical certificates and, where applicable, results from methods validated for the grade and application in question. Historical batch data can be disclosed for evaluation of longitudinal process capability and consistency. Reported results typically depend on the intended use—technical customers may focus on bulk purity, while fine chemical clients may specify more restrictive impurity thresholds or require characterization by complementary chromatography and spectroscopy. For complex formulations or formulations regulated regionally, dedicated data dossiers can be assembled to include retest periods, packing integrity evaluations, and recommendations for storage controls.
Production schedules match real purchasing patterns, developed from a combination of historical order review and projection workshops with established clients. Capacity allocation decisions follow strategic reviews of both major input availability and scheduled maintenance windows. Advance planning with procurement partners reduces rushes and volatile price swings, supporting predictable supply. Business cooperation can be handled through annual volume contracts, rolling forecasts, or spot order frameworks, depending on the customer’s planning horizon and risk appetite.
Key process equipment for 2-Chloroacetoacetanilide synthesis remains dedicated to this product stream, with redundancy for high-sensitivity operations. Automated control points in charging, reaction, and crystallization phases continuously log critical parameters to secure reproducible product quality at scale. Any raw material disruptions are tracked, and alternate sourcing protocols are available where integration with upstream supply chains is feasible. Consistent intermediate hold protocols and multiple filtration and washing stages help manage potential variability in crude purity.
Technical assessment samples are available under an established request pathway, anchored in standard internal protocols for batch segmentation and trace documentation. Upon receipt of a formal application, sample sub-batches are reserved from fully qualified production runs and packed according to expected downstream handling needs. Shipping documents identify exact batch history and reference analytical profiles. Depending on downstream requirements, support teams collaborate to replicate customer-relevant testing to ease transition from pilot to scaled use.
Collaboration arrangements can be adapted according to forecast certainty, inventory strategy, and integration of transport requirements. For routine annual requirements, fixed-schedule bulk release may offer efficiency in allocation and logistics. Partners managing more variable demand cycles may opt for call-off order mechanisms, with minimum and maximum volume ranges negotiated to balance flexibility and supplier planning confidence. Technical teams integrate feedback from customer trials directly into ongoing production improvement programs, treating each cooperation mode as a source of process enhancement feedback rather than a rigid model. This approach allows adjustments not only on quantity and frequency, but, where demanded, on packing format, documentation standards, and shipping lead times—all within the boundaries of what is validated and proven stable from the manufacturing process side.
In the field of acetoacetanilide derivatives, substitution on the aromatic ring and halogenation patterns in 2-Chloroacetoacetanilide receive the most R&D attention. Process teams have seen growing demand for grades supporting low-residual-chloride requirements, particularly for use in active pharmaceutical ingredients and specialty pigment precursors. Variation of synthesis route and raw material integrity directly affect the byproduct profile. Engineers currently compare different catalytic systems and explore reaction media that minimize off-odors and discoloration, which are concerns during downstream formulation. In practical terms, end-users in agricultural and pharmaceutical intermediates show consistent interest in controlling trace impurities, especially when downstream processes require clean conversions.
Clients in agrochemicals look for this chloro-acetanilide as a pivotal intermediate for selective fungicides and herbicide actives. Research groups in colorant synthesis target enhanced coupling yields with controlled halogen content, seeking to cut both waste and hazardous residue. Specialty resin and polymer segments have begun testing this compound as a cross-link initiator, aiming for improved durability in high-performance coating systems.
On the production side, the biggest challenge lies in managing trace-level impurities that stem from residual starting materials or hydrolysis products. Each plant run must address equipment corrosion and safe handling of chlorinated intermediates—common sources of batch variability. Current quality control teams monitor batch traceability, focusing on purity by both chromatographic and spectroscopic methods. The drive for breakthrough lies in advanced purification approaches that increase yield without compromising on end purity, especially for pharmaceutical-use lots. Technicians have reported success using optimized crystallization protocols and upgraded scrubbing systems for off-gas, which improved batch uniformity and reduced lot-to-lot variance in impurity levels.
Demand trends link closely to expansion in agricultural chemical products and increasing investment in high-performance pigments. Service teams expect customers to seek tighter lot release parameters with the phase-in of stricter downstream regulatory requirements in both North America and East Asia. From a supply perspective, cost fluctuations in aromatic amines and acetylating agents remain material risks but can be managed in long-term procurement planning. The baseline outlook holds steady with moderate market growth, reinforced by downstream consumer product regulations driving higher quality standards.
Production teams anticipate greater automation and in-line quality monitoring. Volumetric dosing and temperature-programmed reactors join the standard toolkit for ensuring batch reproducibility. Second-generation synthesis routes, such as those incorporating continuous flow, show promise for both yield enhancement and process safety. Facilities upgrading solvent recovery and effluent treatment capabilities expect to see reduced overall processing costs over time, as environmental restrictions tighten.
Pressure to advance green synthesis grows each year. Key steps toward sustainability include raw material stewardship, halogen management in waste streams, and adoption of less hazardous solvents. Internally, plants have adopted closed-system handling and additional containment during chlorination stages, reducing fugitive emissions. Ongoing R&D explores water-based reaction alternatives and bio-derived starting materials, though these are not yet standard for high-volume contracts due to cost and scalability limitations.
Application engineers work hands-on with customer technical groups, reviewing batch data and historical lot performance during new project initiation. Each consultation prioritizes application-specific concerns, such as solubility in bespoke solvent systems or the impact of minor isomer content in pigment synthesis, based on supplied technical data. Teams document all casework to guide future plant adjustments or secondary process recommendations.
In production transfer or scale-up scenarios, plant chemists offer trial sample guidance, including feedback on factors such as stirring efficiency, batch charge sequence, and temperature profiles, all of which influence final isolate characteristics. For customers formulating agricultural actives, technical support reviews additive compatibility and filtration efficiency based on grade differentiation. Typically, support includes detailed batch analysis reports, allowing customers to optimize filtration, crystallization, or solvent selection according to observed behavior in actual-use conditions.
Each shipment is backed by traceable batch documentation, with retention samples kept according to defined internal and agreement-based periods. If a performance variance or non-conformity appears, quality teams conduct root-cause analysis, engaging production and logistics teams to resolve the problem efficiently. Adjustments to future lots are made based on analytical findings. Ongoing partnerships with key buyers include periodic technical reviews and feedback loops, sustaining process consistency and continuous improvement.
Producing 2-Chloroacetoacetanilide requires precise control from raw material sourcing to process optimization. In our plant, all batch parameters undergo rigorous monitoring to meet industrial-grade standards. We manage each synthesis step, from chlorination to downstream purification, with close attention to reaction conditions and impurity profiles. This disciplined approach ensures stability in both output and specification, supporting downstream applications without fluctuation.
Downstream users in the agrochemical sector rely on 2-Chloroacetoacetanilide as a cornerstone intermediate for a range of crop protection actives. Its chemical structure supports efficient acetoacetylation, enabling scalable synthesis routes for advanced herbicides. Across the dye sector, compound purity remains central to reliable colorant manufacturing, safeguarding pigment stability and final product appearance.
In our facility, every production cycle ends with a detailed inspection—quality oversight does not stop at the reactor. Each lot undergoes chemical assay, by-product identification, and trace impurity measurement in our laboratory. Sampling procedures follow documented protocols and retain samples allow traceability down to each drum. Specifications do not drift from published protocols, serving industrial buyers that integrate the intermediate into tightly-regulated production flows.
As bulk manufacturers, we utilize industry-standard packaging lines for large-scale deliveries. Packaging—whether fiber drums, lined bags, or custom containers—takes place under environmental control to prevent moisture uptake and contamination. Automation ensures pack weights and labels comply with shipment norms, and storage conditions support both domestic and international supply chains. Integrated logistics planning supports both spot purchases and scheduled blanket orders, with clear documentation from warehouse to dock.
We track supply histories and technical application feedback from large industrial clients. Process engineers and formulation chemists receive support on handling, formulation compatibility, and reactivity concerns specific to their production environment. If process changes arise, we review analytical data and support troubleshooting to maintain production uptime on the buyer’s end. Our team provides practical insights grounded in actual batch histories, not just general theory.
Consistent supply chains start with controlled production. By owning and operating our manufacturing line, we eliminate variables linked to inconsistent material quality or unexplained specification shifts. Procurement teams gain measurable value—predictable lead times, transparency on lot histories, and readiness to accommodate volume adjustments as planning cycles change. For distributors integrating chemical ingredients at scale, working with a direct manufacturer reduces risk and tightens cost structures.
The combination of controlled synthesis, thorough testing, and industrial logistical systems shapes the value proposition for our commercial partners. By managing every step of production and delivery, we support efficiency in both upstream sourcing and downstream application across competitive sectors.
As a direct manufacturer of 2-Chloroacetoacetanilide, we have dealt with every aspect of its physical properties to support our downstream partners in pharmaceuticals, pigments, and agricultural intermediates. Working at industrial scale, precision and reproducibility matter. Our technical staff monitors each batch, as even small deviations in melting point can signal purity or process variance.
Most published references put the melting point of 2-Chloroacetoacetanilide in the range of 83°C to 86°C, though slight fluctuations may occur according to purity and handling. Our in-house analytical laboratory routinely confirms a melting range within this window for production lots. A sharp, consistent melting point testifies to controlled synthetic procedures and minimal contaminant loading, a core concern in scale manufacturing.
End-users rely on these melting point figures for downstream reaction design and quality assurance protocols. A deviation as small as two degrees could signify either trace impurities or solvent residues from isolation, both of which our production team mitigates through carefully monitored recrystallization and drying routines. Feedback from our partners confirms reliable performance when strict adherence to process guidelines supports these physical constants.
Solubility often defines how readily process engineers can handle, formulate, and blend intermediates such as 2-Chloroacetoacetanilide. Our records and tests indicate the compound exhibits low solubility in cold water but dissolves more readily in hot water, aligning with its acetoacetyl structure and chloro substituent. Solubility in common organic solvents, especially ethanol, methanol, and acetone, remains moderate to good. For example, integrating into organic-phase reactions or extractions rarely poses operational challenges.
Clients working with aqueous systems will need to account for the low water solubility at ambient temperatures. Our technical staff sometimes recommend gentle heating or co-solvent systems in pilot studies or batch scale-ups. Most frequently, a mixed solvent approach (e.g., alcohol and water or acetone-water) achieves workable concentrations during downstream coupling or pigment dispersions. That flexibility influences process yields and streamlines downstream isolation.
Over years of bulk production, trends emerge: process bottlenecks almost always trace back to material-handling puzzles, often boiling down to solubility mismatches or temperature fluctuations in melting. We address recurring bottlenecks by sharing technical data gathered from actual manufacturing cycles, not just literature values. These insights keep our partners’ lines running, whether they're tailoring crystallization steps or solvent streams in multi-ton reactors.
We also observe that maintaining tight lot-to-lot consistency in melting and solubility assures smoother operation for customers using precision dosing or in-line blending systems. By providing measured values and analytical transparency, we cut down on ramp-up lead times and support rapid method validation.
Our plant process strives for not only correct specifications but practical benefits during handling—pouring, transferring, and dissolving. Every feedback loop that points to a solubility complaint or an off-spec melt leads to a process review on our floor. Through these cycles, we optimize both endpoint purity and bulk flow characteristics, reinforcing reliable performance across diverse application fields.
In summary, both melting point and solubility profiles guide real-world handling of 2-Chloroacetoacetanilide far beyond mere specification sheets. Our firsthand experience, plant data, and day-to-day troubleshooting allow us to support innovation along the full value chain, from process engineer to product formulator.
Procurement for 2-Chloroacetoacetanilide starts with an honest assessment of what it takes to operate a chemical production plant running at scale. This compound does not come from a high-throughput commodity line; production requires specialized equipment and a controlled environment to secure consistent purity. Our investment in process controls over the years shapes both the scale at which we manufacture and our willingness to commit line time for every order.
MOQ stands at a straightforward intersection of plant efficiency and customer need. For 2-Chloroacetoacetanilide, our experience shows that batch production remains the most effective way to guarantee both cost control and product quality. Every campaign mobilizes raw materials, quality checks, and packaging resources. An MOQ lower than the batch size leads to unnecessary stoppages and wasted materials, which cost real money and time for everyone involved.
For this reason, our standard MOQ stays at 250 kilograms per order. This quantity reflects not market tradition, but the direct realities of safe, efficient plant operation and reliable supply. We designed our packaging and logistics to suit this volume, minimizing transit risks and material loss.
In an age of supply chain disruptions, lead time has moved front and center in every customer’s mind. For 2-Chloroacetoacetanilide, our plant operates equipment dedicated for chlorination, condensation, and purification sequences. Factoring raw material availability, batch scheduling, and quality assurance, we typically achieve a lead time of 18 to 23 calendar days from receipt of official purchase order.
This window includes in-house lab analysis for every lot, as well as routine safety compliance checks. Some customers ask why not shorter—tight schedules are possible for inventory on hand, but fresh production maintains the physical properties end-users demand. Our long-term supply contracts allow for adjusted lead times if forecast planning takes place; sudden spikes in demand usually require extra notice to safely balance downstream production.
Our direct manufacturing approach means we exert full control from raw ingredient intake to finished goods quality. This lets us keep MOQ and lead time transparent and predictable. We communicate openly if there are raw material shortages or maintenance that could affect timelines. Our technical team stands ready to share our batch production records and offer guidance for downstream formulation or intermediates synthesis.
Regular dialogue with our customers helps us understand evolving market pressures—such as urgent project launches or shifts in regulatory demands—which can influence ordering patterns for 2-Chloroacetoacetanilide. We encourage advance forecasting where possible; in turn, we can consider campaign production or consignment stock when long-term cooperation supports mutual efficiency.
As a manufacturer, predictable MOQ and lead time represent a commitment, not just a policy. By producing and packaging 2-Chloroacetoacetanilide directly from our own facility, we aim to remove uncertainty from the buying process. Our customers receive a product that matches agreed quality, at a timeline that aligns with their own production needs—anchored by our real-world operational experience.
Every shipment leaving our plant follows procedures developed from decades in chemical manufacturing. For products like 2-chloroacetoacetanilide, nothing gets overlooked—especially compliance documentation and labeling for transport safety. Regulatory requirements aren't something we see as red tape; they exist because incidents in transit can have far bigger consequences than a simple paperwork delay.
2-chloroacetoacetanilide, used widely as an intermediate for agrochemicals and dyes, falls within chemical classes that trigger mandatory handling guidelines. Under prevailing Globally Harmonized System (GHS) criteria, this intermediate often aligns with hazardous material categories. Conclusive classification depends on batch testing, impurity profiles, and up-to-date SDS reviews. As a result, all our bulk or packaged shipments include labeling in line with GHS and relevant transport hazard codes, both in English and local language if required. Our team checks every batch against UN guidelines for dangerous goods before it leaves our site.
No consignment leaves our facility without a Safety Data Sheet reflecting its composition and safety instructions, supported by our batch test records. Our documentation always shows the current international and national regulatory alignment, not just a generic label. Couriering to EU, US, or Asia? Our documentation covers REACH, TSCA, and other applicable frameworks, including any special handling or customs declarations.
We don't cut corners on container resilience or external marking. Over years of working with both sea and air freight, we've learned the smallest lapse invites trouble for the receiving warehouse and shippers alike. Drums, bags, or IBCs all bear standardized hazard and precautionary pictograms. Batch numbers are marked visible for traceability from our plant floor down to the end user warehouse. Each shipment moves with physical and digital documentation for customs, environmental, and safety inspections. No step gets left to chance, from package sealing to palletization certifications.
Different shipping routes and local laws prompt adjustments. International air shipment? We follow ICAO/IATA specifications, which require special marking and declaration. Road or rail within national borders invokes ADR rules or country-level cargo regulations. Our logistics team handles these directly, working off real-time regulatory bulletins. Where authorities require prior notification of hazardous goods arrival, we process advance filings as part of our standard export protocol.
Every operator on our packing line has periodic training updates on compliance documentation, container hazard labels, and new legislation. Internal audits and mock inspections let us catch and close any compliance gaps. If a transport firm raises an issue at the port or customs checkpoint, our compliance managers respond directly with the original SDS, test report, and photo evidence of labeling at the point of dispatch.
We see compliance as an integral part of delivering 2-chloroacetoacetanilide, not as an afterthought once the order is won. Our workflow helps keep each shipment legal, traceable, and safe, right to the consignee’s dock.
For product inquiries, sample requests, quotations or after-sales support, please feel free to contact me directly via sales7@bouling-chem.com, +8615371019725 or WhatsApp: +8615371019725
